DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2A and adra2b

DIOPT Version :10

Sequence 1:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster
Sequence 2:XP_002932610.1 Gene:adra2b / 100485811 XenbaseID:XB-GENE-999343 Length:410 Species:Xenopus tropicalis


Alignment Length:586 Identity:143/586 - (24%)
Similarity:218/586 - (37%) Gaps:215/586 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   287 FLFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYW 351
            ||.||.:|       ||:||.:||...|.|:...|.||.|||.||:||:..::|.......:|||
 Frog    21 FLVLFTIF-------GNVLVIIAVLTSRSLKAPQNLFLVSLAAADILVATLIIPFSLANELMGYW 78

  Fly   352 PLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLG-SRHRSTKRLTGIKIAIVWVMAMM 415
            ..|.|||.:|:..|||.|:|||:|:|.|||.||..:...:. :..|:.||:..| |.|||.:|.:
 Frog    79 YFGKTWCEMYLALDVLFCTSSIVHLCAISLDRYWSVSQAIEYNSKRTPKRIKCI-ILIVWTLAAL 142

  Fly   416 VS-SSITVLGLVNEKNIMPEPNICVINNRAFFVF-GSLVAFYIPMLMMVTTYALTIPLLRKKARF 478
            :| ..:...|...::|..||   |.:|...:::. .|:.:|:.|.|:|:..| |.|.|:.|: |.
 Frog   143 ISLPPLIYKGKSKDQNAKPE---CKLNEEPWYILSSSICSFFAPCLIMILVY-LRIYLIAKR-RN 202

  Fly   479 AAEHPESELFRRLGGRF------TLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEE 537
            .....:.:|.:...|.|      :|...|:|.|..:.||   .....|::.|             
 Frog   203 RKNSTDKKLKKMAPGLFSRTNKHSLNSSHTQTQCGIISS---QEKTGLALDD------------- 251

  Fly   538 GGAPSRRSGVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGI 602
                 ...||     |::.            |.|...||.|.:.|...:.....|:         
 Frog   252 -----LHCGV-----PVLS------------STREERNGHSESFGLQPQGENLKHT--------- 285

  Fly   603 FRHSSSSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQP 667
                                      :|..|.:||                              
 Frog   286 --------------------------NGCEPAVMD------------------------------ 294

  Fly   668 QLGYPTNVGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQAAGGNHM 732
                                                        .:||::|.:|           
 Frog   295 --------------------------------------------TVATVKGVML----------- 304

  Fly   733 VQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQKATKVLGL 797
                .|...|..:                         |::..|::.::     .|::.|.||.:
 Frog   305 ----MPKGAKDSD-------------------------LSSAKKKSYIN-----REKRFTFVLAV 335

  Fly   798 VFFTFVLCWSPFFILNIIFAACPE-CQVPEHVVNTCLWLGYVSSTINPIIYTIFNRTFRAAFIRL 861
            |...|||||.|||....:.|.|.| |.:|:.|.....|:||.:|::||:||||||:.||.||.|:
 Frog   336 VIGVFVLCWFPFFFTYSLGAICTELCYIPDSVFQFFFWIGYCNSSLNPVIYTIFNQDFRKAFRRI 400

  Fly   862 L 862
            |
 Frog   401 L 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 66/177 (37%)
TM helix 2 321..343 CDD:410628 11/21 (52%)
TM helix 3 359..381 CDD:410628 11/21 (52%)
TM helix 4 404..420 CDD:410628 7/16 (44%)
TM helix 5 443..466 CDD:410628 5/23 (22%)
7tm_GPCRs <779..858 CDD:475119 33/79 (42%)
TM helix 6 792..814 CDD:410628 12/21 (57%)
TM helix 7 826..851 CDD:410628 11/24 (46%)
adra2bXP_002932610.1 7tmA_alpha2B_AR 7..397 CDD:320444 139/580 (24%)
TM helix 1 14..40 CDD:320444 11/25 (44%)
TM helix 2 47..73 CDD:320444 11/25 (44%)
TM helix 3 85..115 CDD:320444 16/29 (55%)
TM helix 4 127..150 CDD:320444 9/23 (39%)
TM helix 5 168..197 CDD:320444 8/29 (28%)
TM helix 6 324..354 CDD:320444 13/34 (38%)
TM helix 7 365..390 CDD:320444 11/24 (46%)

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