Protein Alignment sac and Dnah7a

DIOPT Version :10

• Sequence 1: NP_649475.3
• Gene: sac / 40568
• FlyBaseID: FBgn0037254
• Length: 1079
• Species: Drosophila melanogaster
• Sequence 2: XP_006496242.1
• Gene: Dnah7a / 627872
• MGIID: 2685838
• Length: 4046
• Species: Mus musculus
• Alignment Length: 1109
• Identity: 224/1109 - (20%)
• Similarity: 401/1109 - (36%)
• Gaps: 325/1109 - (29%)

  Fly    85 MDKMGKAHRFPLP-TILPKVIQT-------RYVPKRHL----------PKDVEVDRRRRQY---- 127
            |||:....:..|| |:||::..|       :..|..||          |..|:.::...:|
Mouse    26 MDKLSSKEKVKLPTTVLPQLSLTGVKPQWQQTAPSFHLNIKQENPVLEPYTVKNEQSFAEYMEHC 90

  Fly   128 -QKINLVNELAKAGLTDDVLQPTEEQYNVMSEFAFPHKFPLSYFDDSNFDINSPAAWFELGVVGD 191
             :|..|:::     :.||...|:..:..|.|    |||      :..||....|:.:
Mouse    91 QKKGKLLDQ-----IDDDRSAPSTSRSKVKS----PHK------ERENFKSTLPSIY-------- 132

  Fly   192 AHYPLPAKAYLPYNQSLLNCQWGMAAVTAHHEDSDLWTLLSLEDGCTYTVPKLQFMFMAEDPHKY 256
                 .:|...|..:. .|.:..:|.|.. .:|..|.:.:..|.|    :||.......:|..:|
Mouse   133 -----RSKIKSPQKER-ENLRSTLAKVIM-QKDGGLESDVIDESG----IPKETTSATEKDISRY 186

  Fly   257 IKRLQAAVHERHKGEQLMLMELIVDCVLHEDIESTVFYSFKPIESVLQAAKVSEQCKRRLRSEVN 321
            ...::..:...|....             ||         ..:|.|||.  |.|..| .|.:.:.
Mouse   187 YYYIRQGLDTDHVAPM-------------ED---------SWLEHVLQL--VPEHLK-VLTNSIK 226

  Fly   322 LVFERLMALYELE------QFILKMPKEFPQFRNINLKEFLPRSFAVDVSGK------ERLELQA 374
            ::.:.:...|.|.      .|:||.|:|                  .|..||      .|.|::.
Mouse   227 VLSDEIREDYLLSVKKSIVDFVLKDPRE------------------KDDDGKITELPPHRAEMEV 273

  Fly   375 LGITMQEKRYDYLKASLFYCVGGIEAMAGVAIECQYIE------------TLSIFICSFSKPLAL 427
            |   .:..|..:|.|                  |.||.            .|.::..:|.| |.|
Mouse   274 L---PKPWRRSFLSA------------------CSYIRDHLNAMNPMMLAVLDLWHSTFKK-LRL 316

  Fly   428 VD---FLQAQEA------------HSDNV-ATFLKVYWPQ------------QLTTVITVVLRAL 464
            ||   |...|:|            |.::. .|.||.::|:            ||.|
Mouse   317 VDIEEFHSCQDALELSEFQNIVIKHMESAKETLLKTWFPEVQNIFNQGNKKKQLPT--------- 372

  Fly   465 GKGW--LDISLNTWTVYLMCKISRFILQVKFRMQESMEVLLETSLMNFSHFVCDPCLQFLELKSN 527
            ||..  ||...|       |..:...||        ::.|:..|:.:|:..:..| |:.:.:
Mouse   373 GKSTAKLDSFFN-------CAATLMTLQ--------LQDLILVSMQDFTDLIAQP-LESIRV--- 418

  Fly   528 YKWTNNYIDTEFPFQKPVFAMTLGISEDRKVFYSTDPDEFQPGLVEIFKKCLEKSSGVRCIDGSV 592
                         |:.|.|.|.| :.:...:.:..:.:|:...|:.|::..::..|.|..::..:
Mouse   419 -------------FEHPGFIMRL-VLDKEAIKFEPEFNEYIDSLINIYEIMIKAVSFVPRVETKL 469

  Fly   593 MS--FLKFAPNLY--ILTVELIEDRFLRENELLKNCYAKAVLP---LRAYARLY-------ERFI 643
            .|  ..|..|...  |:..|:|:....:..|::   ..::|.|   |:.|.:..       ||.|
Mouse   470 YSQWESKSKPTTLKPIILNEIIDTHKEKIREVI---LRESVAPTEHLKMYDKYQFLITGKAERDI 531

  Fly   644 DFYLLNVNTYMQAYAQAHKPSSEVKRDILENKRLKEELREILPAFITIGPFYINVDTMKQFMIKK 708
            |..|.....|           ..:..:|.:.::|.||::......:.:|.|.::.:.:.:.:: |
Mouse   532 DELLFQNQNY-----------ERLIEEIRKYQKLGEEIQYTSQKTVCLGMFEMHCEELIRSLV-K 584

  Fly   709 RIEVV--RRIFEYYVDRMYETNEVLLDRCLEMFRRIAER----PISIEHLYEIRDFAQTVPDLVD 767
            |.:|:  :.|.:.:.|.. |.|.:|.|.    |.:|||:    |::...|.|::...|.: :..|
Mouse   585 RADVICGKLIAKMFRDHQ-EVNTMLCDE----FEKIAEKALSTPLNTAELMEMKAHVQKL-ETTD 643

  Fly   768 ELKADIQVMWLEYDLLDSFF--------YNLSDHQFAMKWNVYAWPHQIMVRLSTLKDEQKVDIE 824
            .|:       |...|:||..        .|.|.....:..:|:.|    ..|:..:.||.:..|:
Mouse   644 MLE-------LGQRLVDSKICLAFLIECVNFSPADIRLNKSVFQW----YGRMGEIFDEHRKIIK 697

  Fly   825 DFLRLHAS----ECQAFEERLESLNDEVQAYSLAFNTNRAQETSVDIKKTWALIKELEKVSQTL- 884
            :...|:..    .|:.|.|.|||...:|:.:. ||..  ..:....::|...|..:|:..:..:
Mouse   698 EKTELYQEFLKFRCERFVEELESYAKQVEEFH-AFGD--LLDVQRYLQKAQVLNGKLDAAADKID 759

  Fly   885 QF--RQELFELEPLSVEFLESIIASFTPYKNLWYGCANF-LKLEDATLG-----NP-IAQLDLED 940
            ||  .:|.|...|.:....:.|..:..||.:|:.....| .|....|.|     || ..:.|:.:
Mouse   760 QFNAEEEAFGWVPSAYPQRKKIQDALNPYLHLYETAVEFSTKHRGWTEGPYHKVNPDQVEADVGN 824

  Fly   941 VWNNLMRLRDELNESMKIFHEKVEIMDVAKTFIAKIDDFVPVYNSIKDIRNENWMYIHWQELSAI 1005
            .|..|.:|.       |:||:....:.:.|...:.:::|......|:...|......||:.:|.|
Mouse   825 YWRGLYKLE-------KVFHDSPNALAMTKKVHSMVEEFKQYIPLIQVFCNPGLRPRHWEAMSTI 882

  Fly  1006 TGQEIKYS--------VAMNYQ-YLIRKGILDVLPEVHIISEKANNEAEEIRRAIEEEERRKQAE 1061
            .|..::.|        :.||.: :|.|.|         .|||.|:.|     .::|:...:...|
Mouse   883 VGYPLQPSDDSTVFSFIDMNLEPFLDRFG---------SISEAASKE-----YSLEKAMDKMMTE 933

  Fly  1062 LNAM 1065
            .::|
Mouse   934 WDSM 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sac	NP_649475.3	DHC_N2	901..>1042	CDD:462462	36/156 (23%)
Dnah7a	XP_006496242.1	DHC_N2	779..1184	CDD:462462	40/180 (22%)
		DYN1	894..3688	CDD:227570	13/58 (22%)
		AAA_6	1312..1638	CDD:463697
		AAA_8	2333..2595	CDD:463701
		AAA_9	2983..3204	CDD:463702
		Dynein_C	3742..4042	CDD:465677