Protein Alignment sac and DNAH7

DIOPT Version :10

• Sequence 1: NP_649475.3
• Gene: sac / 40568
• FlyBaseID: FBgn0037254
• Length: 1079
• Species: Drosophila melanogaster
• Sequence 2: NP_061720.2
• Gene: DNAH7 / 56171
• HGNCID: 18661
• Length: 4024
• Species: Homo sapiens
• Alignment Length: 1123
• Identity: 214/1123 - (19%)
• Similarity: 393/1123 - (34%)
• Gaps: 322/1123 - (28%)

  Fly    32 DDSQFKREAEKAICIMPPRPGTTMMNYQELYIPRNQLTDVYYPIQEAQRWLTLMDKMGKAHRFPL 96
            |.|..|.:::|.:..:|                  ||:               |:|:....:|..
Human     6 DKSASKEKSKKPVRFLP------------------QLS---------------MEKLASKEKFKA 37

  Fly    97 PT-ILPK--VIQTR-----YVPKRHLPKDVEVDRRRRQYQKINLVNELAKAGLTDDVLQPTEEQY 153
            |. .||:  ::.|:     ..|..||    .|.:.....:..::.||.:.|            :|
Human    38 PARALPQLSMVSTKPHWQQAAPSFHL----SVKQDDESPEPFSVKNEQSHA------------EY 86

  Fly   154 NVMSEFA----FPHKFPLSYFDDSNFDINSPAAWFELGVVGDAHYPLPAKAYLPYNQSLLNCQWG 214
              |..|.    .||:...||...|.......:               |.|....:..:|:|
Human    87 --MERFGKKGKLPHQVDDSYVGPSTSKSKGKS---------------PHKERENFRSTLVN---- 130

  Fly   215 MAAVTAHHEDSDLWTLLSLEDGCTYTVPKLQFMFMAEDPHKYIKRLQAAVHERHKGE-QLMLMEL 278
                ....:|:||.:  ::.||.  |:||.....:.:|..:|...:...:...|... :...:|.
Human   131 ----VIMQQDADLDS--AVPDGS--TIPKPTASAIEKDILRYYYYIHHGIDTDHVAPMEDSWLEH 187

  Fly   279 IVDCV---LHEDIESTVFYSFKPIESVLQAAKVSEQCKRRLRSEVNLVFERLMALYELEQFILKM 340
            ::|.|   |....:|.|..|.:..|..|.:.:.|                       :..|:||.
Human   188 VLDLVPQHLKVFTDSIVTLSDEMREDYLLSVRKS-----------------------IVDFVLKD 229

  Fly   341 PK---------EFPQFRNINLKEFLP----RSFAVDVSGKERLELQALGITMQEKRYDYLKASLF 392
            |:         |.|..|  ...|.||    :|| :..|...|..|.|:..||
Human   230 PREKGDDKKTDELPAHR--AEMEILPKPWRKSF-LAASSYIRDHLNAMNPTM------------- 278

  Fly   393 YCVGGIEAMAGVAIECQYIETLSIFICSFSKPLALVD---FLQAQEA------------HSDNV- 441
                              :..|.::..:|.| |.|||   |...|:|            |.|:.
Human   279 ------------------LAVLDLWHTNFKK-LRLVDIKEFHNCQDALELSSFQNIIMRHMDSAK 324

  Fly   442 ATFLKVYWPQQLTTVITVVLRALGKGWLDISLNTWTVYLMCKISRFILQVKFRMQESMEVLLETS 506
            .|.||:::|:    |..:..:...|..|....::      .|:..|.......|...::.|...|
Human   325 ETLLKMWFPE----VQNIYYQGNKKKQLPTGDSS------AKLESFFNCAAALMTLQLQDLTLVS 379

  Fly   507 LMNFSHFVCDPCLQFLELKSNYKWTNNYIDTEFPFQKPVFAMTLGISEDRKVFYSTDPDEFQPGL 571
            :.:|:..:..|                 .|:...|:.|.|.|        ::....|..:|:|.|
Human   380 MQDFTDLIAQP-----------------PDSVRAFEHPGFIM--------RLILDNDTIKFEPEL 419

  Fly   572 ---VEIFKKCLEKSSGVRCIDGSVMSFLKFAP----NLY--------------ILTVELIEDRFL 615
               ::||....:          .::..:.|.|    .||              |:..|:::
Human   420 SDYIDIFLNVYD----------VMIKAVSFVPRVETKLYSKWESKSKPTTLKPIILNEIVD---- 470

  Fly   616 RENELLKNCYAKAVLPLRAYARLYERFIDFYLL-----NVNTYMQAYAQAHKPSSEVKRDILENK 675
            ...|.:|....|..:....:.|||::: ||.:.     :|:.::   |:.|. ..::..:|.:.:
Human   471 AHKEKIKEVIMKESVAPTEHLRLYDKY-DFLITRKAERDVDNFL---AENHS-YEKIIDEICKYQ 530

  Fly   676 RLKEELREILPAFITIGPFYINVDTMKQFMIKKRIEVVRRIFEYYVDRMYETNEVLLDRCLEMFR 740
            :|.||::......|.:|.|.::.:.:.:.::|:...:..::    :.:|:..::.:..|..:.|.
Human   531 KLIEEIQYTSIKTIRLGMFEMHCEELIRALVKRADIICGKL----LAKMFRDHQEVNTRLCDEFE 591

  Fly   741 RIAERPISIEHLYEIRDFAQTVPDLVD--ELKADIQ------VMWLEYDLLDS--------FFYN 789
            ||||:.:|            |.|:..:  |:||.||      ::.||..|:||        .:.|
Human   592 RIAEKALS------------TPPNTAELMEMKAYIQKVEVTDMIELEQRLVDSKNCLAFLIEYVN 644

  Fly   790 LSDHQFAMKWNVYAWPHQIMVRLSTLKDEQ----KVDIEDFLRLHASECQAFEERLESLNDEVQA 850
            .|.....:..:|:.|    ..|:..:.:|.    |..||.:.......|:.|.|.|||...:.:.
Human   645 FSPADMRLNNSVFQW----YGRMGEIFEEHRKIIKEKIEQYQEGLKLRCERFVEELESYAKQSEE 705

  Fly   851 YSLAFNTNRAQETSVDIKKTWALIKELEKVSQTL-QF--RQELFELEPLSVEFLESIIASFTPYK 912
            :   ::....|:....:||...|..:|:..:..: ||  .:|.|...|......:.|.....||.
Human   706 F---YSFGDLQDVQRYLKKAQILNGKLDLAADKIEQFNAEEEAFGWLPSVYPQRKKIQDGLNPYL 767

  Fly   913 NLWYGCANFLKLEDATLGNPI-------AQLDLEDVWNNLMRLRDELNESMKIFHEKVEIMDVAK 970
            .|:.....|.....|....|.       .:.|:.:.|..|.:|.       |.||:....:.:.|
Human   768 RLYETAVEFSSNYRAWTEGPYHKVNPDQVEADIGNYWRGLYKLE-------KTFHDSPYALAMTK 825

  Fly   971 TFIAKIDDFVPVYNSIKDIRNENWMYIHWQELSAITGQEIKYSVAMNYQYLIRKGILDVLPEVHI 1035
            ...:|::||......|:.|.|......||:.:|||.|..::.|........:...:...:.....
Human   826 KVRSKVEDFKQHIPLIQVICNPGLRPRHWEAMSAIVGYPLQPSDDSTVSSFLDMNLEPYIDRFEG 890

  Fly  1036 ISEKANNEAEEIRRAIEE 1053
            |||.|:.| ..:.:|:|:
Human   891 ISEAASKE-YSLEKAMEK 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sac	NP_649475.3	DHC_N2	901..>1042	CDD:462462	32/147 (22%)
DNAH7	NP_061720.2	Stem. /evidence=ECO:0000250	1..1289		214/1123 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		6/36 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..121		18/104 (17%)
		DHC_N2	757..1162	CDD:462462	35/159 (22%)
		DYN1	959..3663	CDD:227570
		AAA_6	1290..1616	CDD:463697
		AAA 1. /evidence=ECO:0000250	1290..1511
		AAA 2. /evidence=ECO:0000250	1571..1802
		AAA 3. /evidence=ECO:0000250	1938..2189
		AAA 4. /evidence=ECO:0000250	2302..2555
		AAA_8	2311..2573	CDD:463701
		Stalk. /evidence=ECO:0000250	2572..2873
		AAA 5. /evidence=ECO:0000250	2954..3184
		AAA_9	2961..3182	CDD:463702
		AAA 6. /evidence=ECO:0000250	3397..3620
		Dynein_C	3720..4020	CDD:465677