Protein Alignment sac and Dnah10

DIOPT Version :10

• Sequence 1: NP_649475.3
• Gene: sac / 40568
• FlyBaseID: FBgn0037254
• Length: 1079
• Species: Drosophila melanogaster
• Sequence 2: NP_062409.1
• Gene: Dnah10 / 56087
• MGIID: 1860299
• Length: 4591
• Species: Mus musculus
• Alignment Length: 1379
• Identity: 242/1379 - (17%)
• Similarity: 452/1379 - (32%)
• Gaps: 494/1379 - (35%)

  Fly    18 FDESSTSSISNKGPDDSQFKREAEKAICIMPPRPGTTMMNYQELYIPRNQLTDVYYPI------- 75
            |..||..:|    |:.:..|...|    |||......::|.|.|.:.::.:..|:.|.
Mouse   164 FLRSSKDAI----PEATDMKEAME----IMPETMEYGVINSQVLQLLKDVICQVFMPALSFNQHK 220

  Fly    76 -QEAQRWLTLMDKMGKAHRFPLPTILPKVIQTRYVPKRHLPKDVEVDRRRRQYQKINLVNE--LA 137
             :..|..|:     |:...|.:..:...|:    :|...:           :|..:.|:.:  |.
Mouse   221 SESGQGTLS-----GENQEFSVYDLAESVV----IPGEPM-----------EYHSVQLIRDEFLM 265

  Fly   138 KAGLTDDVLQPTEEQYNVMSEFAFPHKFPLSYFDDSNFDINSPAA----------WFELGVVGDA 192
            .....::.:|.|.:|.....:...|   .:|...|.:..:::|..          |     :|..
Mouse   266 NLQKFENNIQRTIQQLEGEIKLEMP---SISVEGDMSELVSNPELVENLEQCVIHW-----LGQI 322

  Fly   193 HYPLPAK-AYLPYNQSLLNCQWGMAAVTAHHEDSDLWTLLSLEDGCTYTVPKLQFMFMAEDPHKY 256
            .|.|.:: ...|.....|             .:.:.|...:......|...||.|:      .|.
Mouse   323 SYALDSQMKKKPQGNGPL-------------AEIEFWRERNATLSALYEQTKLPFV------RKV 368

  Fly   257 IKRLQAAVHERHKGEQLMLMELIVDCVLHEDIE------STVFYSFK-------------PIESV 302
            ::.::.|........|.:|.||.   .||.:..      |||...||             .|.|:
Mouse   369 LEVIKEAESMLTANVQPILTELF---KLHMEASDNVRFLSTVERHFKNITHGSSFHVVLDTIPSM 430

  Fly   303 LQAAKVSEQCKRRLRSEVNL----------VFERLMALYELEQFILKMPKEFPQFRNINLKEFL- 356
            :.|.::.....|....:..:          :.||:..:..| :.:.|..:...||:....:..|
Mouse   431 MSALRMVWIISRHYNRDERMIPLMERIAWEIAERVCRVINL-RTLFKENRANAQFKTQEARNTLK 494

  Fly   357 --PRSFAVDVSGKERLELQALGITMQEKRYDYLKASLFYCVGGIEAMAGVAIECQ----YIETLS 415
              .:|: .|:    |.:::|.|   :|.|:::.:..||   ...:.||.:   ||    .::.|.
Mouse   495 LWKKSY-FDI----RAKIEASG---REARWEFDRKRLF---ERTDYMANI---CQDLSDVLQVLE 545

  Fly   416 IFICSFSKP--------------LALVDFLQA--QEAHSDNVATFLKVYWPQQLT--TVITVVLR 462
            .|...|...              |..||.|.|  :....|..:.....||...:.  .:..:|:.
Mouse   546 EFYNIFGPELKAVTGDPKRIDDVLGRVDSLVAPMESLSFDPFSIRSSPYWKYVMEDFKLEVLVIE 610

  Fly   463 ALGKGWLDISLNTWTVYLMCKISRFILQVKFRMQESMEVLLETSLMNFSHFVCDPCLQFLELKSN 527
            ...|.::|.|..|    |....:.|.:.:||:...|.|.:....:|.|:..          |...
Mouse   611 KEAKNFIDESFKT----LRSAEAAFDMLLKFKHIRSREAINRQMMMKFNDI----------LAQY 661

  Fly   528 YKWTN--NYIDTEFPFQKPVF----AMTLGISEDRKVFYS--------------TDPD------- 565
            ||..:  |.|..:.....|::    .:...|..:|.:||.              .|.:
Mouse   662 YKEIDIVNKIFVQNQDNPPLYKNHPPVAGAICWERSLFYRIKHTILRFMEVEELLDSERGQQVKQ 726

  Fly   566 ----------EFQPGLVEIFKKCLEKS-------------------SGVRCIDGSVMSFLKFAPN 601
                      |::.|..|.:|:..|:|                   |.:  ||......:.|:|.
Mouse   727 RYLEVGRKMKEYEDGKYEHWKETTEQSLPTLMKKSLLTKNIITAEDSAI--IDRGTTFIINFSPV 789

  Fly   602 L--------YI-----------LTVELIEDRFLRENE----------LLKNCYAKAVLP------ 631
            |        |:           ..|.|.||:|||..|          ||.|...:|...
Mouse   790 LKEIINETKYLEQLGFTIPELARNVALQEDKFLRYTEGIQRMLDHYHLLINTLNEAETALLDDHS 854

  Fly   632 ---LRAYARLYERFIDFYLLNVNTYMQAYAQA-----------HKPSSEV--KRDILENKRL--- 677
               ||.:...|:| :::..|.::.|:....||           ||.:.::  :..::|:..|
Mouse   855 QELLRVFRSGYKR-LNWNSLGISDYITRCKQAIGKFETLVHQIHKNADDINSRLTLIESVSLFRF 918

  Fly   678 --------------------KEELREI---LPAFITIGPFYINVDTMKQFMIKKRIEVVRRIFEY 719
                                :|..|::   :..::.|||....|:.:.......|...:...:||
Mouse   919 PVAKTADGVPGVKEFFEYIERERARDVDHMVRWYMAIGPLLTKVEGLVVHTNTGRAPKLASYYEY 983

  Fly   720 YVDRMYETNEVLLDRCLEMFRRIAERPISIEHLYEIRDFAQTV---PDLV--------DEL---- 769
            :..::|:....|:.:.|:.|..:..|.:.   |::    |:|:   |::|        |::
Mouse   984 WEGKIYDVLVKLIQKNLQAFNSLILRNVP---LFQ----AETILSAPEIVLHPNANEIDKMCVHC 1041

  Fly   770 -KADIQ-----VMWL--------------EYDLLDSFFYNLSDH--------------------- 793
             ::.::     |.|:              |..::.||:.::|.:
Mouse  1042 VRSCVEVTKHFVRWMNGSCIECPPQKGEEEEVVIISFYNDISQNTQIMDQALMIPQNIHRLLVNI 1106

  Fly   794 -QFAMKWNVY-----------------------AWPHQI---------MVRLSTLKDEQKVDIED 825
             ::..:|..|                       |:..::         ::|...:|||..:.::
Mouse  1107 MKYLQRWKRYRPLWKLDKSIVMEKFAAKKPACVAYDEKLQFYSKIATDVMRHPLIKDEHCIRLQ- 1170

  Fly   826 FLRLHASECQ----------------AFEERLESLNDEVQAYSLAFNTNRAQETSVDIKKTWALI 874
             |...||..|                :..|.|.||.||::  .||.|..::..|..|:|...|.|
Mouse  1171 -LEPLASTVQENAKSWVISLGKLLNESAREELYSLRDEIE--HLAKNLKKSPSTLEDLKFVLATI 1232

  Fly   875 KELEKVSQTLQFR----QE------LFELEPLSVEFLESIIASFTPYKNLWYGC-ANFLKLEDAT 928
            .|:...|..::.|    ||      ::::.|...|  :.::.:.   :|:|... ...:.:|.|.
Mouse  1233 SEIRSKSLVMELRYKDIQERYRTMAIYKIFPTDTE--QELVNNI---ENMWESLFTESMNVEHAL 1292

  Fly   929 LGNPIAQLDLEDVWNNLMRLRDELNESMKIF----------------------------HEK--V 963
            .|  |.:...|...:.:|..|.:|:|..:.|                            |||  .
Mouse  1293 GG--IKRTFTEITRSEIMNYRSQLDEFARRFYSQGPGAVGEDLDKGSELLGSFEKELAKHEKNRQ 1355

  Fly   964 EIMDVAKTF---IAKIDDFVPV-------------YNSIKDIRNENWMYIHWQELSAITGQEIKY 1012
            |:.:..|.|   |....:.:.|             |||:| :..|.|....|
Mouse  1356 ELANAEKLFDLPITMYPELIKVQKEMTGLRMIYELYNSLK-LAKEEWSQTLW------------- 1406

  Fly  1013 SVAMNYQYLIRKGI 1026
             :.:|.||| ::||
Mouse  1407 -INLNVQYL-QEGI 1418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sac	NP_649475.3	DHC_N2	901..>1042	CDD:462462	33/173 (19%)
Dnah10	NP_062409.1	DHC_N1	308..878	CDD:462457	113/628 (18%)
		DYN1	1272..4233	CDD:227570	33/168 (20%)
		DHC_N2	1374..1779	CDD:462462	14/61 (23%)
		AAA_6	1914..2240	CDD:463697
		AAA_8	2893..3152	CDD:463701
		Dynein_C	4290..4588	CDD:465677