DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14651 and CG3339

DIOPT Version :9

Sequence 1:	NP_649475.3	Gene:	CG14651 / 40568	FlyBaseID:	FBgn0037254	Length:	1079	Species:	Drosophila melanogaster
Sequence 2:	NP_001036762.2	Gene:	CG3339 / 43295	FlyBaseID:	FBgn0039510	Length:	4842	Species:	Drosophila melanogaster

Alignment Length:	1008	Identity:	185/1008 - (18%)
Similarity:	334/1008 - (33%)	Gaps:	338/1008 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 IKRLQ-AAVHERHKGEQLMLMELIVDC-------------VLH--EDIESTVFYSFKPIESVLQA 305
            |..|| .|:.|||..|.:.|.:|...|             :.|  |||::||..:.|
  Fly  1613 ITELQNPAITERHWMELMQLTKLSYKCNKSTRLAQLLTLQLQHHEEDIKNTVDRAIK-------- 1669

  Fly   306 AKVSEQCKRRLRSEVNLVFERLMALYELEQFILKMPKEFPQFRNINLKEFLPRSFAVDVSGKERL 370
                |....::..|:...:..|.  :||||...:     |..:.:.:.|.|     ::.....::
  Fly  1670 ----EMTVTKVLDEIKATWAHLE--FELEQHHTR-----PHIQLLKVSEEL-----IETLDDNQM 1718

  Fly   371 ELQALGITMQEKRYDYLKASLFY---CVGGIEAMAGVAIECQ----YIETLSIFICSFSKPLAL- 427
            :||.:..:   |..:||...|.:   .:|||:.:.....|.|    |:|  .|||.|......|
  Fly  1719 QLQNISTS---KHIEYLLDKLTHWQKVLGGIDTLIVNWFEVQRKWIYLE--CIFIGSADIRAQLP 1778

  Fly   428 VDFLQAQEAHSDNVATFLKVYWPQQLTTVITVVLR---ALGKGWLDISLNTWTVYLMCKISRFIL 489
            .|....:....|..|...||   |::..|:.||||   .|.:                     :|
  Fly  1779 ADAANFERIDEDFTALLAKV---QEVRVVMQVVLRHDDVLAQ---------------------LL 1819

  Fly   490 QVKFRM---QESMEVLLETSLMNFSHFVCDPCLQFLELKSN-----------YKWTNNYIDTEFP 540
            |::.|:   ::::...|||..:.|..|........|::.||           .|..::.:..::.
  Fly  1820 QLQHRLAVCEKALNDYLETKRLAFPRFYFISAADLLDILSNGNNPQVIDRHLIKLFDSILRLQYE 1884

  Fly   541 FQKPVFAMTLGI----SEDRKVFYSTDPDEFQPGLV----------------------EIFKKCL 579
            ...|   ..||:    :::...|.|.|||  ||..:                      |:|::.|
  Fly  1885 TNTP---NALGMHSKENDEYVPFVSFDPD--QPAFIVCGGRVELWLRAIIQQMRSTLHELFRRAL 1944

  Fly   580 ----EKSSGVRCIDGSVMSFLKFAPNLYILTVE----LIEDRFLRENELLKNCYAKAVLPLRAYA 636
                ||...:...|......|..:...:...|.    .:|:.:   ..::|..:.:.:..|.|..
  Fly  1945 RVFGEKPRELWLYDWPAQVALCCSQISWTADVNRSFGCMEEGY---EGVMKELHKRQIAQLNALI 2006

  Fly   637 RLY---------ERFIDFYLLNVNTYMQAYAQAHKPSSEVKRDILENKRLKEELREILPAFITIG 692
            .|.         ::.:....::|:            |.:|...|:.:|
  Fly  2007 NLLLGELSPGDRQKIMTICTIDVH------------SRDVVGKIIASK----------------- 2042

  Fly   693 PFYINVDTMKQFMIKKRI-------------------------------EVVRRIFEYYVDRMYE 726
                 ||....|..:.::                               .:....|.|..:.:..
  Fly  2043 -----VDNSLAFQWQSQLRHRWDDDQAGSSSGRASTAISCGGGDEDCFANICDAEFRYAYEYLGN 2102

  Fly   727 TNEV----LLDRCLEMFRRIAERPISIEHLYEIR-----------DFAQTVPDLVDELKADIQVM 776
            |:.:    |.|||.          |::.....:|           ...:|..||...|...:.|.
  Fly  2103 TSRLVITPLTDRCY----------ITLTQSLRLRLAGATAGPAGTGKTETTKDLGRALGVMVYVF 2157

  Fly   777 ----WLEYDLLDSFFYNLSDHQFAMKWNVYAWPHQIMVRLSTLKDEQKVDIEDFLRLHASECQAF 837
                .::|....:.:..|:.   ...|..:...::|.|.:.::...|...|::.:::|.::....
  Fly  2158 NCSEQMDYKSCGNIYKGLAQ---TGAWGCFDEFNRICVEVLSVVAVQVKTIQEAIKMHKTQFIFM 2219

  Fly   838 EERLESLNDEVQAYSLAFNTNRAQETSVD------------IKKTWALIKELEKVSQTLQ----F 886
            .||: ||...|..: :..|...|..|.:.            |...:|||.|:..:::..|    .
  Fly  2220 GERI-SLEPSVGIF-ITMNPGYAGRTELPENLKTLFRPCAMIVPDFALICEIMLMAEGFQDARLL 2282

  Fly   887 RQELFELEPLSVEFL-------------ESIIASFTPYKNLWYGCANFLKLEDATLGNPIAQLDL 938
            .::...|..|..|.|             :|::.           .|..||.:|.:  .|..|:
  Fly  2283 ARKFITLYTLCKELLSKQDHYDWGLRAIKSVLV-----------VAGTLKRDDHS--RPEDQV-- 2332

  Fly   939 EDVWNNLMRLRDELNESMKIFHEKVEIMDVAKTFIAKIDDFVP--------VYNSIKDIR----- 990
                  |||...:.| ..||..|.|.|      |:..|.|..|        |:...|.||
  Fly  2333 ------LMRALRDFN-IPKIVTEDVPI------FMGLIGDLFPALDVPRKRVFEFEKTIRRAVNE 2384

  Fly   991 -----NENWM--YIHWQEL-----------SAITGQEIKYSVAMNYQYLIRKGILDVLPEVHIIS 1037
                 .|.::  .:..|||           :|.|| :.|....:...|.|:|    :.|..|:::
  Fly  2385 IKLQPEEGFLMKVVQLQELLDVRHSVFIVGNAGTG-KTKIWQTLRETYRIQK----LKPVCHVLN 2444

  Fly  1038 EKANNEAEEIRRAIEEEERRKQAELNAMLLRKQ 1070
            .||.:. :|:...:....|..:..|.:.::|:|
  Fly  2445 PKALSN-DELFGIVNPTTREWKDGLFSSIMREQ 2476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14651	NP_649475.3	DHC_N2	904..>1042	CDD:285579	38/168 (23%)
CG3339	NP_001036762.2	DHC_N1	276..903	CDD:285571
		DHC_N2	1535..1944	CDD:285579	82/388 (21%)
		P-loop_NTPase	2095..2324	CDD:304359	43/254 (17%)
		P-loop_NTPase	2409..2544	CDD:304359	16/74 (22%)
		P-loop_NTPase	2731..3061	CDD:304359
		P-loop_NTPase	3138..3406	CDD:304359
		MT	3419..3759	CDD:289543
		AAA_9	3789..4001	CDD:289547
		Dynein_heavy	4142..4832	CDD:281078
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450575
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930