DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14651 and CG9068

DIOPT Version :9

Sequence 1:	NP_649475.3	Gene:	CG14651 / 40568	FlyBaseID:	FBgn0037254	Length:	1079	Species:	Drosophila melanogaster
Sequence 2:	NP_611111.1	Gene:	CG9068 / 36817	FlyBaseID:	FBgn0034106	Length:	1227	Species:	Drosophila melanogaster

Alignment Length:	834	Identity:	155/834 - (18%)
Similarity:	306/834 - (36%)	Gaps:	242/834 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 IKRLQAAVHERHKGEQLMLMELIVDCVLHEDIESTVFYSFKPIESVLQAAKVSEQCK--RRLRSE 319
            ::||...|.::....:.||          |.:::.:|||::. ...|:...:.|..|  |....|
  Fly   526 VQRLIFNVFQQVSNVEEML----------EALQAMLFYSYRQ-RGTLRKTYLKETSKLWRMFSKE 579

  Fly   320 VNLVFERLMALYELEQFILKMPKEFPQFRNINLK------------EFLPRSFAVDVSGKERLEL 372
            ::....:|:.....|.::.|.......:| |||:            |:||   ||..|.....:.
  Fly   580 MDATSRKLLEEQSRESWLSKHVSIALGYR-INLERLTWLRDRLKNSEWLP---AVKESSPALAKF 640

  Fly   373 QALGITMQEKRYDYLKASLFYCVGGIEAMAGVAIECQYIETLSIFICSFSKPLALVDFLQAQEAH 437
            .||       |:::.|                .|...|.:.:: ..|.||..|.
  Fly   641 DAL-------RHEFQK----------------EIRLAYDDWVA-KCCGFSGDLC----------- 670

  Fly   438 SDNVATFLKVYWPQQLTTVITVVLRALGKGWLDISLNTWTVYLMCKISRFILQVKFRMQESMEVL 502
                         |:|...:.|..:.. ||.|:.:::. :|..:|:.::...::.|.:..:|:.|
  Fly   671 -------------QRLDRYLVVRSKKF-KGLLECNIDA-SVLELCEQAQHFERMGFAIPSTMKKL 720

  Fly   503 LETSLMNFSHFVCDPCLQFLELKSNYK------WTNNYI-----DTEFPFQKP------------ 544
            .|               ::..::|.|.      .::|.|     |.|....:|
  Fly   721 YE---------------RYDTIRSLYNGIIKLALSHNRILAVLSDRERKLFRPLIQACDRQLAPG 770

  Fly   545 VFAMTLGISEDRKVFYSTDPD---EFQPGLVEIFKKCLEKSSGVR--C--IDGSVMSFLKFAPNL 602
            ||.:|.| ||..:.|:....:   |||. ||.|||:.   :.||.  |  |.|:.:....|:.::
  Fly   771 VFKITYG-SEFNEEFFEDGTEFIAEFQE-LVLIFKRA---NRGVARICEKICGTCLLHFAFSGSV 830

  Fly   603 YI-LTVELIEDRFLRENELLKNCYAKAVLPLRAYARLYERFIDFYLLNVNTYMQAYAQAHKPSSE 666
            .| :..:.:..|.....::|::.|:..|..|.|::..::        :|:..|.|...|:....:
  Fly   831 DISVFQQQLSSRLSSSGDILRSYYSHVVELLSAFSGQFQ--------SVDDEMSAEWIAYVNDMD 887

  Fly   667 VKRDILENKRL---KEELREILPAFITIGPFYINVDTMKQ--FMIKKRIEVVRRIFEYYVDRMYE 726
               |:|.:..:   :..|.::..|      .:.:.|....  .:::..::..|.:|...:|.:.:
  Fly   888 ---DMLASSLMTSARGSLNKLYEA------LHCDADMASAPIIVVESDVKDGRIVFTPDMDAIGD 943

  Fly   727 TNEVLLD---RCLEMFRRIAERPISIEHLYEIRDFA------QTVPDLVDELKADIQVMWLEYDL 782
            ....::|   ..|:.|.|:..: :.:....:.:.||      |...:|:..::|:|.:...|...
  Fly   944 MINGIVDSIRSMLDQFPRLGYK-LKLPKKQQRQGFASVFREDQECSELMRSIQAEIGIQREELAK 1007

  Fly   783 LDSFFYNLSDHQFAMKWNVYAWPHQIMVRLSTLKDEQKVDIEDFLRLHASECQAFE---ERLESL 844
            .:|            :||      :..|...|.::|    ....|...:.....||   |...:|
  Fly  1008 YES------------EWN------KNRVLWQTTEEE----FRQRLMSKSRTAGVFEGGIEHYSAL 1050

  Fly   845 NDEV-------QAYSLAFNTNRAQETSVDIKKTWALI------------------------KELE 878
            .|:|       ..|.:..|.|..:.|.:|..:.|..:                        :.:.
  Fly  1051 ADDVIFEDAITNVYFILINQNALKSTMLDWIEKWQALNIKMLLDHGSNLMGAVYRYMRRNERNVM 1115

  Fly   879 KVSQTLQ---FRQELFELEPLSVEFLESIIASFTPYKNLWYGCANF-LKLEDATLGNPIAQLDLE 939
            ||.:|::   ..::|||.....|...:|   :|||...|:.....: :||.:.|...   .:.||
  Fly  1116 KVPRTIRETVAAKQLFEKLLKDVPVKQS---AFTPMLELFVLLHKYQVKLSEETFEQ---VMGLE 1174

  Fly   940 DVWNNLMRLRDELNESMKIFHEKVEIMDVAKTFIAK--------IDDFVPVYNS 985
            ..|.:.:::.:|.:|.:.  :|..|    ||..:||        :.||:..:.|
  Fly  1175 TAWLHYLQVLEEADEMLD--NEDSE----AKLLLAKHGEKFKLILKDFLEDFYS 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14651	NP_649475.3	DHC_N2	904..>1042	CDD:285579	21/91 (23%)
CG9068	NP_611111.1	DHC_N1	211..784	CDD:285571	62/338 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450604
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930