Protein Alignment sac and DNAH1

DIOPT Version :10

• Sequence 1: NP_649475.3
• Gene: sac / 40568
• FlyBaseID: FBgn0037254
• Length: 1079
• Species: Drosophila melanogaster
• Sequence 2: XP_016861618.1
• Gene: DNAH1 / 25981
• HGNCID: 2940
• Length: 4288
• Species: Homo sapiens
• Alignment Length: 1138
• Identity: 275/1138 - (24%)
• Similarity: 515/1138 - (45%)
• Gaps: 162/1138 - (14%)

  Fly    47 MPPRPGTTMMNYQELYIPRNQL---TDVYYPIQEAQRWLT------LMDKMGKAHR--------- 93
            :||.|.|    ..:|..||...   ||..||:.:.:.:.:      .:|::|:..|
Human    64 LPPAPPT----LSDLGQPRKSPLTGTDKKYPLMKQRGFYSDILSPGTLDQLGEVCRGPRMSQNLL 124

  Fly    94 -----------------------------------------FPLPTILPKV-IQTRYVPKRHLPK 116
                                                     |||....||: :..:.:|.:| |:
Human   125 RQADLDKFTPRVGSFEVPEDFQERMEQQCIGSTTRLLAQTDFPLQAYEPKMQVPFQVLPGQH-PR 188

  Fly   117 DVEVDRRRRQYQKINLVNELAKAGLTDDVLQP---------TEEQYNVMSEFAFPHKFPLSYFDD 172
            .:|::||::||..:::...|...|:..:.|.|         |.||.:   :..||...||..||:
Human   189 KIEIERRKQQYLSLDIEQLLFSQGIDSNKLMPRHLDHQHPQTIEQGH---DPIFPIYLPLKVFDN 250

  Fly   173 SNFDINSPAAWFELGVVGDA--HYPLPAKAYLPYNQSL---------LNCQWGMAAVTAHHEDSD 226
            .:||..:|..|..:|:...:  ..|:|.||.||.:..|         |..:|....|..:.|:..
Human   251 EDFDCRTPREWINMGLEPGSLDRKPVPGKALLPTDDFLGHEDPKSQKLKYKWCEVGVLDYDEEKK 315

  Fly   227 LWTLLSLEDG--------------------------CTYTVPKLQFMFMAEDPHKYIKRLQAAVH 265
            |:.:...::.                          |.|.||::|.:|.||||..:.:|:..|..
Human   316 LYLVHKTDEKGLVRDEMGRPILNAGVTTEGRPPLQVCQYWVPRIQLLFCAEDPCMFAQRVVQANA 380

  Fly   266 ERHKGEQLMLMELIVDCVLHEDIESTVFYSFKPIESVLQAAKVSEQCKR---------RLRSEVN 321
            .|...|.|:|..|.||| :..|.:..:  |.:.:..:.|.|..:.:.::         .|..||:
Human   381 LRKNTEALLLYNLYVDC-MPSDGQHVI--SEQSLSKIKQWALSTPRMRKGPSVLEHLSSLAREVS 442

  Fly   322 LVFERLMALYELEQFILKMPKEFPQFRNINLKEFLPRSFAVDVSGKERLELQALGIT------MQ 380
            |.:||.|.....:..:...|:.|....       ||:        ||..::...|:.      ..
Human   443 LDYERSMNKINFDHVVSSKPETFSYVT-------LPK--------KEEEQVPERGLVSVPKYHFW 492

  Fly   381 EKRYDYLKASLFYCVGGIEAMAGVAIECQYIETLSIFICSFSKPLALVDFLQAQEAHSDNVATFL 445
            |::.|:...||......|.|::.|..||..:..:|:|..|.||...|.:|.|.|......|..||
Human   493 EQKEDFTFVSLLTRPEVITALSKVRAECNKVTAMSLFHSSLSKYSHLEEFEQIQSQTFSQVQMFL 557

  Fly   446 KVYWPQQLTTVITVVLRALGKGWLDISLNTWTVYLMCKISRFILQVKFRMQESMEVLLETSLMNF 510
            |..|...|...:...||.:.|||.::....|.||||.|:.:.:..||:.:|:::..|::.||.:|
Human   558 KDSWISSLKVAMRSSLRDMSKGWYNLYETNWEVYLMSKLRKLMELVKYMLQDTLRFLVQDSLASF 622

  Fly   511 SHFVCDPCLQFLELKSNYKWTNNYIDTEF-PFQKPVFAMTLGISEDRKVFYSTDPDEFQPGLVEI 574
            |.|:.|.|...|....:..|.::.|::.: |.:.|:|.|.| :.:...|.|||..::|:..|:.:
Human   623 SQFISDTCCSVLNCTDDMVWGDDLINSPYRPRKNPLFIMDL-VLDSSGVHYSTPLEQFEASLLNL 686

  Fly   575 FKKCLEKSSGVRCIDGSVMSFLKFAPNLYILTVELIEDRFLRE---NEL---LKNCYAKAVLPLR 633
            |.|.:..:..|..::..||.      :::|....|:|...|.|   .||   :.:..:||::||:
Human   687 FDKGILATHAVPQLEKLVME------DIFISGDPLLESVGLHEPLVEELRATIASAVSKAMIPLQ 745

  Fly   634 AYARLYERFIDFYLLNVNTYMQAYAQAHKPSSEVKRDILENKRLKEELREILPAFITIGPFYINV 698
            |||:.|.::::....::.::::.|......:.||:..:|.:.|.||.|...||:.|.|||||||.
Human   746 AYAKEYRKYLELNNNDIASFLKTYQTQGLLAQEVREVVLTHLREKEILDSSLPSSIIIGPFYINT 810

  Fly   699 DTMKQFMIKKRIEVVRRIFEYYVDRMYETNEVLLDRCLEMFRRIAERPISIEHLYEIRDFAQTVP 763
            |.:||.:.|||..:...:.:.....:::..:.:.:....:.|:|.|:|.|||.|.|:|::.:.:|
Human   811 DNVKQSLSKKRKALATSVLDILAKNLHKEVDSICEEFRSISRKIYEKPNSIEELAELREWMKGIP 875

  Fly   764 DLVDELKADIQVMWLEYDLLDSFFYNLSDHQFAMKWNVYAWPHQIMVRLSTLKDEQKVDIEDFLR 828
            :.:..|:..|..:..:|.::|.|.||||...|..||....||.:|:.::..::.:...|.|.|.:
Human   876 ERLVGLEERIVKVMDDYQVMDEFLYNLSSDDFNDKWIASNWPSKILGQIELVQQQHVEDEEKFRK 940

  Fly   829 LHASECQAFEERLESLNDEVQAYSLAFNTNRAQETSVDIKKTWALIKELEKVSQTLQFRQELFEL 893
            :...:...|:|:||.|...|..:|:....:||.|.:.::::....:|:.::::.....|:.:|.|
Human   941 IQIMDQNNFQEKLEGLQLVVAGFSIHVEISRAHEIANEVRRVKKQLKDCQQLAMLYNNRERIFSL 1005

  Fly   894 EPLSVEFLESIIASFTPYKNLWYGCANFLKLEDATLGNPIAQLDLEDVWNNLMRLRDELNESMKI 958
            ...:.:.|..::..|.||.:||...:::|:..::.:.:|::.:|.|.:..|::.....:::.:|.
Human  1006 PITNYDKLSRMVKEFQPYLDLWTTASDWLRWSESWMNDPLSAIDAEQLEKNVVEAFKTMHKCVKQ 1070

  Fly   959 FHEKVEIMDVAKTFIAKIDDFVPVYNSIKDIRNENWMYIHWQELSAITGQEIKYSVAMNYQYLIR 1023
            |.:.....:||....|:|::|.|....|:.:||......||:.||......::....:.:...:.
Human  1071 FKDMPACQEVALDIRARIEEFKPYIPLIQGLRNPGMRIRHWETLSNQININVRPKANLTFARCLE 1135

  Fly  1024 KGILDVLPEVHIISEKANNEAEEIRRAIEEEER 1056
            ..:.|.:..:..::|.|..| ..|.:|:::.|:
Human  1136 MNLQDHIESISKVAEVAGKE-YAIEQALDKMEK 1167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sac	NP_649475.3	DHC_N2	901..>1042	CDD:462462	29/140 (21%)
DNAH1	XP_016861618.1	DHC_N2	1013..1416	CDD:462462	33/156 (21%)
		DYN1	<1252..3921	CDD:227570
		AAA_6	1543..1869	CDD:463697
		AAA_8	2579..2840	CDD:463701
		Dynein_C	3982..4284	CDD:465677