DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14651 and Dnah1

DIOPT Version :9

Sequence 1:	NP_649475.3	Gene:	CG14651 / 40568	FlyBaseID:	FBgn0037254	Length:	1079	Species:	Drosophila melanogaster
Sequence 2:	NP_001028840.1	Gene:	Dnah1 / 110084	MGIID:	107721	Length:	4250	Species:	Mus musculus

Alignment Length:	1198	Identity:	292/1198 - (24%)
Similarity:	534/1198 - (44%)	Gaps:	188/1198 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QEFDESSTSSISNKGP-----------------DDSQFKREAEKAICIMPPRPGTTMMNYQELYI 63
            :|.::...|| |::||                 .:|.:..|...    :.|.|.|..:...:|..
Mouse     2 EECNKEGPSS-SSQGPGYCPVKVPESHDLEKILQESNYHPERNP----LNPDPKTPPLPLTDLRQ 61

  Fly    64 PRNQL---TDVYYPIQEAQRWLT------LMDKMGKA---------------------------- 91
            ||...   ||..||:.:.:.:.:      .:||:|..
Mouse    62 PRKSPLTGTDKKYPLMKQRGFYSDILSPGTLDKLGNVCCGPYMSQNLIRQADLDKFTPKVDSFVI 126

  Fly    92 ----------------------HRFPLPTILPKVIQTRYVPKRHLPKDVEVDRRRRQYQKINLVN 134
                                  ..|||.:..|||.....|.....|:.:|::||::||.::::..
Mouse   127 PEDFQERVEQQIIGATTRLLTQTDFPLQSYEPKVQVPFQVLPGQCPRKIEIERRKQQYLRLDIEQ 191

  Fly   135 ELAKAGLTDDVLQP---------TEEQYNVMSEFAFPHKFPLSYFDDSNFDINSPAAWFELGVV- 189
            .|...|:..:.|.|         |.||..   :..||...||..||:..||..:|..|..:|:.
Mouse   192 LLTSEGIDSNKLMPRHPDLQHPQTIEQGR---DPLFPIYLPLKVFDNEEFDCRTPTEWLNMGLEP 253

  Fly   190 -GDAHYPLPAKAYLPYNQSL---------LNCQWGMAAVTAHHEDSDLWTLLS------------ 232
             .....|:|.||.||.:..|         |:.:|....|..:.|:..|:.:..
Mouse   254 GSQNRKPVPGKALLPTDDDLGHEDPKNQELDYRWCEVGVLDYDEEKKLYLVQKTDKRGLVRDEMG 318

  Fly   233 ---LEDGCT-----------YTVPKLQFMFMAEDPHKYIKRLQAAVHERHKGEQLMLMELIVDC- 282
               |..|.|           |.||::|.:|.||||..:.:|:..|...|...|.|::..|.|||
Mouse   319 MPILNGGITPAGRPPLLATQYWVPRIQLLFCAEDPRVFTQRVVQANALRKYTEALLMYNLYVDCM 383

  Fly   283 ------VLHEDIESTVFY------SFKPIESVLQAAKVSEQCKRRLRSEVNLVFERLMALYELEQ 335
                  |::|...|.:..      ..:..:|||:..    .|   |..||||.:||.|.....:|
Mouse   384 PTEGRRVINEQSLSKIKQWALSTPRMRKGQSVLEHL----SC---LAREVNLDYERSMNKINFDQ 441

  Fly   336 FILKMPKEFPQFRNINLKEFLPRSFAVDVSGKERLELQALGIT------MQEKRYDYLKASLFYC 394
            .:...|:.|..   :.|.|            ||..::...|:.      .:|::.|:...||...
Mouse   442 IVSSNPETFSY---VTLPE------------KEEEKVPNQGLVSVPEYPFREQKEDFTFVSLLTR 491

  Fly   395 VGGIEAMAGVAIECQYIETLSIFICSFSKPLALVDFLQAQEAHSDNVATFLKVYWPQQLTTVITV 459
            ...|.|::.|..||..:.::|:|..|.||...|.:|.|.|......|..|||..|...|...:..
Mouse   492 PEVITALSKVRAECNKVTSMSLFHSSLSKYSRLEEFEQIQSQTFSQVQMFLKDSWISTLKVAMRG 556

  Fly   460 VLRALGKGWLDISLNTWTVYLMCKISRFILQVKFRMQESMEVLLETSLMNFSHFVCDPCLQFLEL 524
            .||.:.|||.::....|.||||.|:.:.:..:|:.:|:::..|::.||.:|:.|:.|.|...||.
Mouse   557 SLRDMSKGWYNLYETNWEVYLMSKLRKLMELIKYMLQDTLRFLVQDSLGSFTQFIGDACCSVLEC 621

  Fly   525 KSNYKWTNNYIDTEF-PFQKPVFAMTLGISEDRKVFYSTDPDEFQPGLVEIFKKCLEKSSGVRCI 588
            ..:..|..:.:::.: |.:.|:|.:.| :.::..|.|||..:.|:..|:.:|.|.:..:..|..:
Mouse   622 VDDMDWGEDLVNSPYKPRKNPLFIVDL-VLDNSGVHYSTPLEHFEMILLNLFDKGILATHAVPQL 685

  Fly   589 DGSVMS--FLKFAPNLYILTVE--LIEDRFLRENELLKNCYAKAVLPLRAYARLYERFIDFYLLN 649
            :..||.  |:...|.|..:.:.  |:|:  ||.|  :.|...||::||:|||:.|.::::....:
Mouse   686 EKLVMEDIFISGDPLLESVGLHEPLVEE--LRAN--ITNAMHKAMMPLQAYAKEYRKYLELNNND 746

  Fly   650 VNTYMQAYAQAHKPSS-EVKRDILENKRLKEELREILPAFITIGPFYINVDTMKQFMIKKRIEVV 713
            ::|:::.| |...||: ||:..::.:.:.||.|...||:.|.|||||||||.:||.:.|||..:.
Mouse   747 ISTFLKTY-QTQCPSAEEVREVVITHLKEKEILDNSLPSSIIIGPFYINVDNVKQSLSKKRKALA 810

  Fly   714 RRIFEYYVDRMYETNEVLLDRCLEMFRRIAERPISIEHLYEIRDFAQTVPDLVDELKADIQVMWL 778
            ..:.:.....:::..:.:.:....:.|:|.|:|.|||.|.|:||:.:.:|:.:..|:..|..:..
Mouse   811 TSMLDILAKNLHKEVDSICEEFRSISRKIYEKPNSIEELAELRDWMKGIPEKLVFLEERIVKVMS 875

  Fly   779 EYDLLDSFFYNLSDHQFAMKWNVYAWPHQIMVRLSTLKDEQKVDIEDFLRLHASECQAFEERLES 843
            :|:::|.|||||:...|..||....||.:|:.::..::.:...|.|.|.::...:...|:|:||.
Mouse   876 DYEVMDEFFYNLTTDDFNDKWAANNWPSKILGQIDMVRQQHVEDEEKFRKIQLMDQNNFQEKLEG 940

  Fly   844 LNDEVQAYSLAFNTNRAQETSVDIKKTWALIKELEKVSQTLQFRQELFELEPLSVEFLESIIASF 908
            |...|..:|:.....||.|.:.::::....:|:.::::.....|:.:|.|...:.:.|..::..|
Mouse   941 LQLVVAGFSIHVEIARAHEIANEVRRVKKQLKDCQQLAMLYNNRERIFGLPITNYDKLSRMVKEF 1005

  Fly   909 TPYKNLWYGCANFLKLEDATLGNPIAQLDLEDVWNNLMRLRDELNESMKIFHEKVEIMDVAKTFI 973
            .||.:||...:::|:..::.:.:|::.:|.|.:..|::.....:::.:|.|.:.....:||....
Mouse  1006 QPYLDLWTTASDWLRWSESWMNDPLSAIDAEQLEKNVIESFKTMHKCVKQFKDIPACQEVALDIR 1070

  Fly   974 AKIDDFVPVYNSIKDIRNENWMYIHWQELSAITGQEIKYSVAMNYQYLIRKGILDVLPEVHIISE 1038
            .:|::|.|....|:.:||......||:.||......::....:.:...:...:.|.:..:..::|
Mouse  1071 TRIEEFKPYIPLIQGLRNPGMRNRHWEVLSNEININVRPKANLTFARCLEMNLQDHIESISKVAE 1135

  Fly  1039 KANNEAEEIRRAIEEEERRKQAELNAML 1066
            .|..|     .|||:...:.:.|.:::|
Mouse  1136 VAGKE-----YAIEQALDKMEKEWSSIL 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14651	NP_649475.3	DHC_N2	904..>1042	CDD:285579	27/137 (20%)
Dnah1	NP_001028840.1	Stem. /evidence=ECO:0000250	1..1527		292/1198 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73		16/75 (21%)
		DHC_N2	998..1401	CDD:369852	34/166 (20%)
		DYN1	<1237..3883	CDD:227570
		AAA_6	1528..1854	CDD:372306
		AAA 1. /evidence=ECO:0000250	1528..1749
		GPAGTGKT motif	1566..1573
		CFDEFNR motif	1616..1622
		AAA 2. /evidence=ECO:0000250	1809..2042
		AAA 3. /evidence=ECO:0000250	2174..2434
		AAA 4. /evidence=ECO:0000250	2532..2784
		AAA_8	2541..2799	CDD:372310
		Stalk. /evidence=ECO:0000250	2799..3097
		AAA 5. /evidence=ECO:0000250	3182..3412
		AAA 6. /evidence=ECO:0000250	3625..3844
		Dynein_C	3944..4246	CDD:375627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850469
Domainoid	1	1.000	314	1.000	Domainoid score	I1288
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840