DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14651 and dnah1

DIOPT Version :9

Sequence 1:	NP_649475.3	Gene:	CG14651 / 40568	FlyBaseID:	FBgn0037254	Length:	1079	Species:	Drosophila melanogaster
Sequence 2:	XP_009304459.3	Gene:	dnah1 / 100317899	ZFINID:	ZDB-GENE-081015-3	Length:	4175	Species:	Danio rerio

Alignment Length:	1010	Identity:	270/1010 - (26%)
Similarity:	490/1010 - (48%)	Gaps:	87/1010 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 PKVIQTRYV-PKRHLPKDVEVDRRRRQYQKINLVNELAKAGLTDDVLQPTEEQYNVMSEFAFPHK 164
            ||| |..|: |..|:|:.:|::||||:|||:::...|::.|:..:.|.|:.:..........|:.
Zfish   116 PKV-QLPYICPPGHVPRKIEIERRRREYQKLDISKLLSEQGINSNQLIPSNQTRTETKNQPDPNY 179

  Fly   165 FPLSYFDDSNFDINSPAAWFELGVVGDA--HYPLPAKAYLPYNQSL---------LNCQWGMAAV 218
            ..|..||:..||..:|..|..||....:  ..|:||||.||...|:         :...|....|
Zfish   180 LSLEIFDNEEFDCRTPEEWLALGYEPGSMNRKPIPAKALLPTKNSIPPVDPQSPAVEYSWQSVGV 244

  Fly   219 ----------TAHHEDSDLW-----------------TLLSLEDGCTYTVPKLQFMFMAEDPHKY 256
                      ..|..|.:.|                 .||..:    |.||:::.:|.||||..:
Zfish   245 LRYSQEKKQYLVHKADCNGWVRDFMGNPILNGGQREGVLLESQ----YWVPRIRLLFCAEDPRVF 305

  Fly   257 IKRLQAAVHERHKGEQLMLMELIVDCV----LH-EDIESTVFYSFKPIESVLQAAKVSEQCKRRL 316
            .:|:|.|.:.|...|...|....|||:    || ..:|....|:..  .|.|| .|..::|:::|
Zfish   306 AQRVQFAENLRQNTEASNLYHHSVDCMPVWHLHPTSLERIRKYALS--TSGLQ-LKCLQECEKQL 367

  Fly   317 RSEVNLVFERLMALYELEQFIL-KMPKEFPQFRNINLKEFLPRSFAVDVSGKERLELQALGITMQ 380
            ..|:||.:.|     .|.|... |:.::.|:  :|.|.:..|.|.      .||..:.......:
Zfish   368 EKELNLEYSR-----TLNQMCFNKVVQDKPE--DITLPQTQPESI------PERGFVSVPNYPFE 419

  Fly   381 EKRYDYLKASLFYCVGGIEAMAGVAIECQYIETLSIFICSFSKPLALVDFLQAQEAHSDNVATFL 445
            :.|..::..||......|..::.|..||..:..:|:|..||:|.|.|.:|..||......:..||
Zfish   420 KNRAAFVFNSLLTKAEVIAVLSRVREECNRVAEMSLFYVSFTKSLRLEEFESAQSQKHSQIHLFL 484

  Fly   446 KVYWPQQLTTVITVVLRALGKGWLDISLNTWTVYLMCKISRFILQVKFRMQESMEVLLETSLMNF 510
            :..|...|...|:..||.....|.:::::...||.|.|:.|.:..::...|:|:..|::.||.:.
Zfish   485 EESWLPALCNGISSNLRDERCSWYNLAVSRCDVYRMSKLCRLMALIRSLQQDSLRFLVQGSLASL 549

  Fly   511 SHFVCDPCLQFLELKSNYKWTNNYIDTEF-PFQKPVFAMTLGISEDRKVFYSTDPDEFQPGLVEI 574
            :..:.|.|...|:......|..:.|::.: |.:||:|::.| :.:...|.|||..:.|:..::.:
Zfish   550 TKLILDACHSVLQCPQELTWGPDLINSPYKPKKKPLFSVDL-VLDQTGVHYSTPLESFETSVINL 613

  Fly   575 FKKCLEKSSGVRCIDGSVMSFLKFAPNLYIL-----TVELIEDRFLRENELLKNCYAKAVLPLRA 634
            |.|.:..:..|..:|..|:      |||:|:     :|.|.|.......|.:.....:|::||:|
Zfish   614 FDKGILSTHNVPQVDKFVL------PNLFIVGEVLWSVGLWEPEVKNLRESISKALKQAIIPLKA 672

  Fly   635 YARLYERFIDFYLLNVNTYMQAYAQAHKPSSEVKRDILENKRLKEELREILPAFITIGPFYINVD 699
            |.|.||.:::.|..:||||::.::|.::...|||:::||:....|.|.:.:|:.|.||||.:||:
Zfish   673 YTREYECYLELYNSDVNTYLELHSQENQTPQEVKQEVLEHLMEVEHLNKSIPSAIIIGPFMVNVE 737

  Fly   700 TMKQFMIKKRIEVVRRIFEYYVDRMYETNEVLLDRCLEMFRRIAERPISIEHLYEIRDFAQTVPD 764
            .::|.::|||..:.:.:.:....|:.:..:.....|..:.:::.|:|.|||.|.|.|::...||
Zfish   738 AIRQSLVKKRKGLAKALLDRLALRLRQQMQDACKECKAISKKLFEKPSSIEELTEQREWMNQVP- 801

  Fly   765 LVDELKADIQVM---WLEYDLLDSFFYNLSDHQFAMKWNVYAWPHQIMVRLSTLKDEQKVDIEDF 826
              ::|||..:::   ..:|||:|.|:|:|||.:|..||:..||||:|:.::.|:..:...|.|.|
Zfish   802 --EQLKAHEEILSKAMSDYDLIDEFYYSLSDEEFKEKWSAMAWPHKILTQMETVSAQHVDDEERF 864

  Fly   827 LRLHASECQAFEERLESLNDEVQAYSLAFNTNRAQETSVDIKKTWALIKELEKVSQTLQFRQELF 891
            .::..::..:|.|||..|...|..:|...|..||.|.:.::::....:||.::::|....|:.||
Zfish   865 DKIQVADQNSFLERLSFLEMVVAGFSGYTNLERAHEVANEVRRVGKQLKECQEMAQLYNNRERLF 929

  Fly   892 ELEPLSVEFLESIIASFTPYKNLWYGCANFLKLEDATLGNPIAQLDLEDVWNNLMRLRDELNESM 956
            .....:...|:.:...|.|:.:||...:::|:..::.|.:|:|.::.|.:..|:......:::.:
Zfish   930 GKPVTNYTELQKLNRDFQPFHDLWKTTSDWLRWHESWLNDPLAAINPEQLERNVTDAYKTMHQCV 994

  Fly   957 KIFHEKVEIMDVAKTFIAKIDDFVPVYNSIKDIRNENWMYIHWQELSAITGQEIKYSVAMNYQYL 1021
            |.|.:.....:||.....||:.|.|....|:.:||......||:.||......::....:.:...
Zfish   995 KQFKDLPACQEVASEIRTKIEAFRPFIPLIRSLRNPGMRNRHWELLSERININMRSRANLTFSLC 1059

  Fly  1022 IRKGILDVLPEVHIISEKANNE--AEEIRRAIEEE 1054
            :..|:.|.:.|:..::::|..|  .|:....:|||
Zfish  1060 LELGLQDHVEEITRVAQEAGKEYSIEQALNKMEEE 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14651	NP_649475.3	DHC_N2	904..>1042	CDD:285579	29/137 (21%)
dnah1	XP_009304459.3	DHC_N2	946..1342	CDD:312039	34/149 (23%)
		MT	1120..3808	CDD:330758
		Dynein_heavy	3474..4170	CDD:308587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596419
Domainoid	1	1.000	326	1.000	Domainoid score	I1160
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840