Protein Alignment sac and Dnah7c

DIOPT Version :10

• Sequence 1: NP_649475.3
• Gene: sac / 40568
• FlyBaseID: FBgn0037254
• Length: 1079
• Species: Drosophila melanogaster
• Sequence 2: XP_011236933.1
• Gene: Dnah7c / 100101919
• MGIID: 3639762
• Length: 4048
• Species: Mus musculus
• Alignment Length: 1100
• Identity: 214/1100 - (19%)
• Similarity: 387/1100 - (35%)
• Gaps: 329/1100 - (29%)

  Fly    85 MDKMGKAHRFPLP-TILPKVIQT-------RYVPKRHL----------PKDVEVDRRRRQY---- 127
            |||:....:..|| |:||::..|       :..|..||          |..|:.::...:|
Mouse    26 MDKLSSKEKAKLPTTVLPQLTLTGVKHQWQQTAPSFHLNIKQENPILEPYTVKNEQSFAEYMEHY 90

  Fly   128 -QKINLVNELAKAGLTDDVLQPTEEQYNVMSEFAFPHKFPLSYFDDSNFD------INSPAAWFE 185
             :|..|:::     :.||...|:..:..|.|    |||      :..|..      |.......|
Mouse    91 RRKGKLLDQ-----IDDDRSAPSTSRSKVKS----PHK------ERENLRSTLVKVIMQQDGGLE 140

  Fly   186 LGVVGDAHYPLPAKAYLPYNQSLLNCQWGMAAVTAHHEDSDLWTLLSLEDGCTYTVPKLQFMFMA 250
            ..|:.::  .:|..|..|..:.:|...:    ...|..|||  .:..|||
Mouse   141 SDVIDES--GIPKVATSPREKDILRYYY----YIRHGIDSD--HVAPLED--------------- 182

  Fly   251 EDPHKYIKRLQAAVHERHKGEQLMLMELIVDCVLHEDIESTVFYSFKPIESVLQAAKVSEQCKRR 315
                .:::.:...|.:..|.....:|      ||.::|.          |..|.:.|.|
Mouse   183 ----SWLEHVLQLVPQHLKVMTNSIM------VLSDEIR----------EDYLLSVKKS------ 221

  Fly   316 LRSEVNLVFERLMALYELEQFILKMPKEFPQFRNINLKEFLPRSFAVDVSGK------ERLELQA 374
                             :..|:||.|:|                  .|..||      .|.|::.
Mouse   222 -----------------IVDFVLKDPRE------------------KDDDGKITELPPHRAEIEV 251

  Fly   375 LGITMQEKRYDYLKASLFYCVGGIEAMAGVAIECQYIE------------TLSIFICSFSKPLAL 427
            |   .:..|..:|.|                  |.||.            .|.::..:|.| |.|
Mouse   252 L---PKPWRRSFLSA------------------CSYIRDHLNAMNPMMLAVLDLWHSTFKK-LRL 294

  Fly   428 VD---FLQAQEA------------HSDNV-ATFLKVYWPQ------------QLTTVITVVLRAL 464
            ||   |.:.|:|            |.::. .|.||.::|:            ||.|
Mouse   295 VDIEEFHKRQDALELSEFQNIVIKHMESAKETLLKTWFPEVQNIYYKGNKKKQLPT--------- 350

  Fly   465 GK--GWLDISLNTWTVYLMCKISRFILQVKFRMQESMEVLLETSLMNFSHFVCDPCLQFLELKSN 527
            ||  ..||...|       |..:...||        ::.|:..|:.:|:..:..|
Mouse   351 GKSSAKLDSFFN-------CAATLMTLQ--------LQDLILVSMQDFTDLIAQP---------- 390

  Fly   528 YKWTNNYIDTEFPFQKPVFAMTLGISEDRKVFYSTDPDEFQPGLVEIFKKCLEKSSGVRCIDGSV 592
                   .::...|:.|.|.|.|.:.:| .:.:..:.:::...||.|::..::..|.|..::..:
Mouse   391 -------PESTRAFEHPGFIMRLVLDKD-NISFEPEFNDYIDILVNIYEIMIKAVSFVPRVETKL 447

  Fly   593 MS--FLKFAPNLY--ILTVELIEDRFLRENELLKNCYAKAVLP---LRAYARLY-------ERFI 643
            .|  ..|..|...  |:..|:|:....:..|::   ..::|.|   |:.|.:..       ||.|
Mouse   448 YSQWESKSKPTTLKPIILNEIIDGHKEKIREVI---LRESVAPTEHLKMYDKYQFLITGKAERDI 509

  Fly   644 DFYLLNVNTYMQAYAQAHKPSSEVKRDILENKRLKEELREILPAFITIGPFYINVDTMKQFMIKK 708
            |.:|.....|           ..:..:|.:.::|:||::......:.:|.|.::.:.:.:.::|:
Mouse   510 DEFLFQSQNY-----------ERLIEEIRKYQKLEEEIQYTSRKAVRLGMFEMHCEELIKSLVKR 563

  Fly   709 RIEVVRRIFEYYVDRMYETNEVLLDRCLEMFRRIAERPISIEHLYEIRDFAQTVPDLVDELKADI 773
            ...:..::    :.:|:..::.......:.|.:|||:.:|.         .....:|: |:||||
Mouse   564 ADIICGKL----IAKMFRNHQKESTMLCDEFEKIAEKALST---------PLNTAELM-EMKADI 614

  Fly   774 Q------VMWLEYDLLDS-----FF---YNLSDHQFAMKWNVYAWPHQIMVRLSTLKDEQKVDIE 824
            |      ::.|...|:||     |.   .|.|.....:..:|:.|    ..|:..:.||.:..|:
Mouse   615 QKVETTDMLELRQRLVDSKNCLAFLIECVNFSPADIRLNNSVFQW----YGRMGEIFDEHRKIIK 675

  Fly   825 DFLRLHAS----ECQAFEERLESLNDEVQAYSLAFNTNRAQETSVDIKKTWALIKELEKVSQTL- 884
            |....:..    .|:.|.|.|||...:|:.:....:....|..   ::|...|..:|:..:..:
Mouse   676 DKTEQYQEALKFRCERFVEELESYAKQVEEFHTFGDLMDMQRY---LQKAQVLNSKLDAAADKID 737

  Fly   885 QF--RQELFELEPLSVEFLESIIASFTPYKNLWYGCANF-LKLEDATLG-----NP-IAQLDLED 940
            ||  .:|.:...|......:.|..:..||..|:.....| .|.:..|.|     || ..:.|:.:
Mouse   738 QFNAEEEAYGWVPSVYPQRKKIQDALNPYLRLYETAVEFSAKHKWWTEGPYHKVNPDQVETDVGN 802

  Fly   941 VWNNLMRLRDELNESMKIFHEKVEIMDVAKTFIAKIDDFVPVYNSIKDIRNENWMYIHWQELSAI 1005
            .|..|.:|.       |:||:....:.:.|...:.:::|......|:.|.|......||:.:|.|
Mouse   803 YWRGLYKLE-------KVFHDSPNALAMTKKVQSMVEEFKQYIPLIQVICNPGLHPRHWEAMSTI 860

  Fly  1006 TGQEIKYSVAMNYQYLIRKGILDVLPEVHIISEKANNEAEEIRRAIEEEERRKQAELNAM 1065
            .|..:|.|........|...:...|.....|||.|:.|     .::|:...:...|.|:|
Mouse   861 VGYPLKPSDDSTVLSFIDMNLEPFLDRFEGISEAASKE-----YSLEKAMDKMMTEWNSM 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sac	NP_649475.3	DHC_N2	901..>1042	CDD:462462	35/147 (24%)
Dnah7c	XP_011236933.1	DHC_N2	757..1162	CDD:462462	39/170 (23%)
		DYN1	959..3690	CDD:227570
		AAA_6	1290..1640	CDD:463697
		AAA_8	2335..2597	CDD:463701
		AAA_9	2985..3206	CDD:463702
		Dynein_C	3744..4044	CDD:465677