DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14650 and DNAJC14

DIOPT Version :9

Sequence 1:	NP_649473.1	Gene:	CG14650 / 40566	FlyBaseID:	FBgn0037252	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_001381616.1	Gene:	DNAJC14 / 85406	HGNCID:	24581	Length:	702	Species:	Homo sapiens

Alignment Length:	704	Identity:	170/704 - (24%)
Similarity:	264/704 - (37%)	Gaps:	231/704 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 PNLQPQIKS-NKLNNPEKKRPLQPKNVNSNA-PKFSEHKT----------------TPVSANSSL 469
            |::.|:|.| :.|.:.....|...:.:..:: ||.::|..                .|..|..
Human    27 PSVDPEIPSFSGLRDSAGTAPNGTRCLTEHSGPKHTQHPNPAHWLDPSHGPPGGPGPPRDAED-- 89

  Fly   470 QNHSNVLNFTPATNSSTSSRKSGSNKINSNASHSNHTGANTHAGSS--SSSSSVN---------- 522
                      |..:.::|..:||   ::...|..|.|| |...|:|  |..|:.|
Human    90 ----------PDQSETSSEEESG---VDQELSKENETG-NQKDGNSFLSIPSACNCQGTPGIPEG 140

  Fly   523 -YSSNNNVSSSSAKRYSSS----------------NLN-PNN----SSGYSYSSKRNRSNAYSST 565
             ||...|.|||:...:.:|                :|. |::    |||....|:|.|.
Human   141 PYSEGGNGSSSNFCHHCTSPALGEDELEEEYDDEESLKFPSDFSRVSSGKKPPSRRQRH------ 199

  Fly   566 NSPTHANSFSSNR-------NYELAKRIIHT----------------------WWIYTLKLL--- 598
            ..||..::....|       .:.|.::....                      ||:..|.:|
Human   200 RFPTKEDTREGGRRDPRSPGRHRLGRKRSQADKRKGLGLWGAEELCQLGQAGFWWLIELLVLVGE 264

  Fly   599 ------------------------TWL----------FYLVYDIVVLGFSMGYERIT-----LAY 624
                                    .|:          ..:::..:..||..|....|     |..
Human   265 YVETCGHLIYACRQLKSSDLDLFRVWMGVWTGRLGGWAQVMFQFLSQGFYCGVGLFTRFLKLLGA 329

  Fly   625 VAALAYARQLQKELKQNSGKPSIWWRSY--------WR----------------------RFDAR 659
            :..||.|..|        |...:.||..        ||                      |....
Human   330 LLLLALALFL--------GFLQLGWRFLVGLGDRLGWRDKATWLFSWLDSPALQRCLTLLRDSRP 386

  Fly   660 FAKNSRLAVWRL----FYKRKPPETTSEQFKTGRLPQTGEEAMYSLLNCKG-----KDAYSILGV 715
            :.:..|:..|..    :.|:......:....:||..|. ||.:..||...|     .:.:.:|||
Human   387 WQRLVRIVQWGWLELPWVKQNINRQGNAPVASGRYCQP-EEEVARLLTMAGVPEDELNPFHVLGV 450

  Fly   716 PPDSSQEQIRKHYKKIAVLVHPDKNKQAGAEEAFKVLQRAFELIGEPENRLIYD-QSIAETLHTE 779
            ...:|..:::|.|:::||:||||||....||||||||:.|::::...|.|..|: :.:||    .
Human   451 EATASDVELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNAEKRKEYEMKRMAE----N 511

  Fly   780 KAWTELHDLLSQLQTKMAEAANTIRCSTCAQRHPRKLTERPHYAARECASCKIRHSAKDGDIWAE 844
            :....:::.||:||..:.||.||:.||.|..:|.|...:|...:||.||.|...|.|::||.|||
Human   512 ELSRSVNEFLSKLQDDLKEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAE 576

  Fly   845 TSMMGLRWKYLALMDGKVYDITEWANCQKGALSHLEPNSHMVQYRIVRGAQQQQQQQQQQQQQQQ 909
            :||:||:..|.||||||||||||||.||:..:|   |::|.|.|.|..|::....:.:|:..
Human   577 SSMLGLKITYFALMDGKVYDITEWAGCQRVGIS---PDTHRVPYHISFGSRIPGTRGRQRAT--- 635

  Fly   910 QQHHQHPQQPHHDRGVHHPGGGVSGVSEATLHEFLDNLYS---GQHPGAHNAFA 960
                  |..|                 .|.|.:||..::.   ||.|.. |.||
Human   636 ------PDAP-----------------PADLQDFLSRIFQVPPGQMPNG-NFFA 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14650	NP_649473.1	DnaJ	708..769	CDD:278647	25/60 (42%)
CG14650	NP_649473.1	Jiv90	802..891	CDD:291562	45/88 (51%)
DNAJC14	NP_001381616.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..148		27/136 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..229		12/69 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..702		4/9 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6994
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4370
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004260
OrthoInspector	1	1.000	-	-		oto90048
orthoMCL	1	0.900	-	-		OOG6_110132
Panther	1	1.100	-	-	LDO	PTHR44665
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8715
SonicParanoid	1	1.000	-	-		X4060
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.980