DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14650 and Dnajc14

DIOPT Version :9

Sequence 1:	NP_649473.1	Gene:	CG14650 / 40566	FlyBaseID:	FBgn0037252	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_001346753.1	Gene:	Dnajc14 / 74330	MGIID:	1921580	Length:	703	Species:	Mus musculus

Alignment Length:	712	Identity:	179/712 - (25%)
Similarity:	276/712 - (38%)	Gaps:	206/712 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 AHASRGKKRSKVSQTAPLKVQQSQSLAQPNLQPQIKS-NKLNNPEKKRPLQPKNVNSNA-PKFSE 457
            ||.|.|               .|.|.:..::.|:|.| :.|.:..:..|...:.:..:: ||:::
Mouse    14 AHRSGG---------------TSLSTSGSSVDPEILSFSGLRDSAETAPNGTRCLKEHSGPKYTQ 63

  Fly   458 HKTTPVSANSSLQNHSNVLNFTP------ATNSSTSSRKSGSNKINSNASHSNHTGANTHAGSS- 515
               .|..|:.|..:|.......|      ...|.|.|.:||   ::...|..|.||.......|
Mouse    64 ---PPNPAHWSDPSHGPPRGPGPPRGGGYPDESETGSEESG---VDQELSRENETGYQEDGSPSF 122

  Fly   516 -SSSSSVN-----------YSSNNNVSSSSAKRYSSS-------NLN-----------PNN---- 546
             |..|:.|           ||...:.||||...:.:|       .|.           |::
Mouse   123 LSIPSACNCQGSPGVPEGTYSEEGDGSSSSLCHHCTSPALGEDEELEEEYDDEEPLKFPSDFSRV 187

  Fly   547 SSGYSYSSKRNRSNAY-------SSTNSPTHANSFSSNRNYELAKRIIHT--------------- 589
            |||....|:|.:....       |....|      .:...:.||::...|
Mouse   188 SSGKKPLSRRQKHRFLIKEDVRDSGRREP------KAPGRHRLARKRSQTDKRRGLGLWGVEELC 246

  Fly   590 -------WWIYTLKLLTWLF-----YLVY----------DI------------------------ 608
                   ||:..|.:|...:     :|:|          |:
Mouse   247 QLGQAGFWWLIELLVLVGEYVETCGHLIYACRKLKGSDLDLFRVWVGVWARRLGGWARMMFQFLS 311

  Fly   609 ----VVLGFSMGYERITLAY-VAALAY---ARQLQKELKQNSGKPSIW-----WRSYWRRFDA-- 658
                .|:|..:...|:..|: :.|||.   ..||........|....|     |...|....|
Mouse   312 QSFFCVVGLLIRILRVVGAFLLLALALFLGCLQLGWRFSVGLGNRLGWRDKTAWLFSWLGSPALH 376

  Fly   659 ---RFAKNS-------RLAVWRL----FYKRKPPETTSEQFKTGRLPQTGEEAMYSLLNCKG--- 706
               ...|:|       ||..|..    :.|::..:..:....:||..|. ||.:..||...|
Mouse   377 HCLTLLKDSRPWQQLVRLIQWGWQELPWVKQRTKKQGNAPVASGRYCQP-EEEVTRLLTMAGVPE 440

  Fly   707 --KDAYSILGVPPDSSQEQIRKHYKKIAVLVHPDKNKQAGAEEAFKVLQRAFELIGEPENRLIYD 769
              .:.:.:|||...:|..:::|.|:::||:||||||....||||||:|:.|::::..||.|..|:
Mouse   441 DELNPFHVLGVEATASDTELKKAYRQLAVMVHPDKNHHPRAEEAFKILRAAWDIVSNPERRKEYE 505

  Fly   770 -QSIAETLHTEKAWTELHDLLSQLQTKMAEAANTIRCSTCAQRHPRKLTERPHYAARECASCKIR 833
             :.:||    .:....:::.||:||..:.||.||:.||.|..:|.|...:|...:||.||.|...
Mouse   506 MKRMAE----NELSRSVNEFLSKLQDDLKEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRL 566

  Fly   834 HSAKDGDIWAETSMMGLRWKYLALMDGKVYDITEWANCQKGALSHLEPNSHMVQYRIVRGAQQQQ 898
            |.|::||.|||:||:||:..|.||||||||||||||.||:..:|   |::|.|.|.|..|::...
Mouse   567 HPAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGIS---PDTHRVPYHISFGSRVPG 628

  Fly   899 QQQQQQQQQQQQQHHQHPQQPHHD------RGVHHPGGGVSGVSEATLHEFLDNLYSGQHPG 954
            ...:|:..         |:.|..|      |....|.|.:|.          .|.::..|||
Mouse   629 TSGRQRAT---------PESPPADLQDFLSRIFQVPPGPMSN----------GNFFAAPHPG 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14650	NP_649473.1	DnaJ	708..769	CDD:278647	25/60 (42%)
CG14650	NP_649473.1	Jiv90	802..891	CDD:291562	45/88 (51%)
Dnajc14	NP_001346753.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..229		49/241 (20%)
		DnaJ	444..505	CDD:365959	25/60 (42%)
		Jiv90	533..621	CDD:373372	46/90 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..643		4/29 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	659..703		5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6986
eggNOG	1	0.900	-	-		E1_KOG0720
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4370
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004260
OrthoInspector	1	1.000	-	-		oto93624
orthoMCL	1	0.900	-	-		OOG6_110132
Panther	1	1.100	-	-	LDO	PTHR44665
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8715
SonicParanoid	1	1.000	-	-		X4060
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.840