DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14650 and si:dkey-121a11.3

DIOPT Version :9

Sequence 1:	NP_649473.1	Gene:	CG14650 / 40566	FlyBaseID:	FBgn0037252	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	XP_009294606.1	Gene:	si:dkey-121a11.3 / 566840	ZFINID:	ZDB-GENE-050208-417	Length:	1060	Species:	Danio rerio

Alignment Length:	496	Identity:	101/496 - (20%)
Similarity:	167/496 - (33%)	Gaps:	108/496 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 PVGPGNFLKVYHCPDNQVSEAGTPLFTHINMASINHHQLQHQHQAAPPTPSQPTPLYELFATNPL 178
            |.||.........|:.:|.....|.:                  .||..|::...:.::..|...
Zfish   504 PQGPSLNSNTLSLPNGEVEGKKIPCW------------------VAPTLPNRLVRIEQIKETYIG 550

  Fly   179 TLPHAQQQDAQHRQPQQTQTQAPTVSQV-----NHSSSSANLLINNL-------VNNW-SPNLTG 230
            |.|.....|..|..|........|..::     ...|...:|.:|.|       .|.. :||  |
Zfish   551 TSPAIVHSDGTHCSPSDNSNGRGTFQKLKKKVRKFDSKRESLYVNGLRTPSPLDCNKLATPN--G 613

  Fly   231 GSYIQFDGEANEMDVVLETSIAQQPQVPNQNLQQP--EPLSQSVNTLPAASKPAKSLKMPLATAT 293
            ......:|.|..::.....::.|  ::|..:.:.|  .||.....  |.:|:||:....||..
Zfish   614 TQMYLLNGVALPLNPYAPDTLGQ--RIPATSSKGPVAPPLPPKAE--PPSSQPAQPTPPPLQP-- 672

  Fly   294 VSPTAINKSSVAVPGQPEGKKRIVAEVKPMPMS-YSDVLSKGTKPSAAGRDMRADNGG--DYSVQ 355
             ..:|:..||......|.       .|..||.| |..|....|           |.||  |...|
Zfish   673 -KKSALKSSSKNRTNDPR-------TVTIMPSSEYHMVHLDST-----------DAGGTVDNCPQ 718

  Fly   356 SQRRPEKEDAYGNREMRT--------SKRSPLHDAKETGSFVPGVGHAHASRGKKRS-KVSQ--- 408
            .|..|    ..|..|.|:        .:.||:..|:.           ...:|::|| .|.|
Zfish   719 EQTPP----VLGYWEDRSVMVTPGALLRTSPVLCARN-----------FPVQGEERSTDVEQHQV 768

  Fly   409 TAPLKVQQSQSLAQPNLQPQIKSNKLNNPEKKRPLQPKNVNSNAPKFSEHKTTPVSANS----SL 469
            |..|....:.|.|:   .||   ::||:...:.|::|.:..:.:|.||:..|.......    ||
Zfish   769 TGQLASDATSSSAE---SPQ---SRLNDGHVRGPIRPVHNRATSPNFSQAVTDADQREGRPKLSL 827

  Fly   470 QNHSNVLNFTPATNSSTSSRKSGSNKINSNASHSNHTGANTHAGSSSSSSSVNYSSNNNVS---S 531
            :...:.:... :.......|.|..::::.:...:::...|:...|.|.|.|..:..::.:.   |
Zfish   828 RRFFSAMGLN-SVGLLGKGRSSSMDQLSLHPKPNSNLNQNSRPTSPSPSPSPTHRHHHQLKKAPS 891

  Fly   532 SSAKRYSSSNLNPNNSSGYSY----SSKRNRSNAYSSTNSP 568
            ....|..|..|....||....    ..|.:||:||:....|
Zfish   892 LQTIRLGSPFLQLRRSSSAQNLQIPRKKTDRSSAYTPGEQP 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CG14650	NP_649473.1	DnaJ	708..769	CDD:278647
CG14650	NP_649473.1	Jiv90	802..891	CDD:291562
si:dkey-121a11.3	XP_009294606.1	DUF4685	317..438	CDD:292365
si:dkey-121a11.3	XP_009294606.1	PDZ_signaling	970..1053	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000