DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14650 and dnj-5

DIOPT Version :9

Sequence 1:	NP_649473.1	Gene:	CG14650 / 40566	FlyBaseID:	FBgn0037252	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_495400.2	Gene:	dnj-5 / 174122	WormBaseID:	WBGene00001023	Length:	915	Species:	Caenorhabditis elegans

Alignment Length:	941	Identity:	217/941 - (23%)
Similarity:	326/941 - (34%)	Gaps:	279/941 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 WPPPPPHLAGPPFAPH---------------------------LQQQQPHMYNEYLFNLSY---S 101
            ||.||     ||::|.                           ...|:....||.|.:|:.   |
Worm    64 WPEPP-----PPYSPRHESWGLPSNANTTLLGSSSLTSSNWFPFTDQKETSSNEILSSLNLAAGS 123

  Fly   102 GQPGQPETYSVLPVGPGNFLKVYHCPDNQVSEAGTPLFTHINMASINHH------QLQHQHQAAP 160
            ..|..|.|.|.:|          |.|.:||..     |.|    :::||      |:|:.:..||
Worm   124 SSPALPSTPSRVP----------HHPSSQVHH-----FHH----NLHHHTHTHNVQVQNHYFGAP 169

  Fly   161 PTPSQPTPLYELFATNPLTLPHAQQQDAQHRQPQQTQTQAPTVSQVNHSSSSANLLINNLVNNWS 225
            |      |..|.|                          .||     .:||:::..|.:.:.|.|
Worm   170 P------PGLESF--------------------------GPT-----RTSSTSSSQIYDAIPNPS 197

  Fly   226 PNLTGGSYIQFDGEANEMD--------------VVLETSIAQQ--------PQVP---------- 258
            .|.||.|.|..|......|              ||.|:||:..        |..|
Worm   198 WNYTGLSNINADSNVLFSDWKNKNSSQTSPVSTVVSESSISSNLETRPVHPPLSPSEVVEIAKEK 262

  Fly   259 -NQNLQQPEPLSQSVNTLPAASKP---AKSLKMPLATATVSPTAINK--SSVAVPGQPEGKKRIV 317
             |.:....|.||:|.........|   .|..|..||....:...|..  :.:.|.|||..    .
Worm   263 KNVSKSYAEHLSKSTAGTQKKGAPIGAEKKQKQELAKKMSNQLPIESIATRIVVKGQPHS----A 323

  Fly   318 AEVKPMPMSYSDVLSKGTKPSAAGRDMRADNGGDYSVQSQRRPEKEDAYGNREMRTSKRSPLHDA 382
            ..|..||.||.||.::                .|::..|.....:.|....:|: :|....|:|:
Worm   324 PVVSRMPFSYRDVAAR----------------SDHTSSSNHPNHQPDELQRKEL-SSADLKLNDS 371

  Fly   383 KETGSFVPGVGHAHASRGKKRSKVSQTAPLKVQQSQSLAQPNLQPQIKSNKLNNPEKKRPLQPKN 447
            |.    |....:.|...||.|:.:..|...|..:..:..|          |:||.:.|:   .|.
Worm   372 KA----VRTKNNDHRETGKTRNTIDPTDFNKKNRVDNEFQ----------KINNRKNKK---EKA 419

  Fly   448 VNSNAPKFSEHKTTPVSANSSLQNHSNVLNFTPATNSSTSSRKSGS------NKINSNASHSNHT 506
            |...|.........||.::|    ..:||....:.|.|...:||.:      .||.|.:|.....
Worm   420 VTEVAAPVIFEGVHPVDSSS----RYDVLKNLESPNQSYHEKKSANGRPPLIQKIFSRSSSPADD 480

  Fly   507 GANTHAGS----SSSSSSVNYSSNNNVSSSSAKRYSSSNLNPNNSSGYSYSSKRNRSNAYSSTNS 567
            ..:|....    .|||:.|:.:.|..|.....||.:..|             :|.|.   .....
Worm   481 IIDTEEEDPHRVRSSSTHVHQNGNGQVKKDQRKRVAQVN-------------QRRRK---GRKEE 529

  Fly   568 PTH-ANSFSSNRNYELAKRIIHTWWIYTLKLLTWLFYLVYDI--------VVLGFSM------GY 617
            |:. .|:||:..:      ::...|.|....|.|...|:.::        |..|.|:      |.
Worm   530 PSWLQNAFSTFVD------VLFFVWGYACFGLQWTLLLIVEVCQKIADIFVTFGKSLWAGTCKGL 588

  Fly   618 ERITLAY---------------VAALAYARQLQKELKQNSGKPSIWWRSYWRRFDARFAKNSRLA 667
            ..:.||:               |..|.:...:..|....:.:...|...
Worm   589 RNVILAFVYLCFFVVFAIKSVVVRLLTFINMIGAEESDETVEEQDWGCK---------------- 637

  Fly   668 VWRLFYKRKPPETTSEQFKTGRLPQTGEEAMYSLLNCKGKDAYSILGVPPDSSQEQIRKHYKKIA 732
                  |..|..|.:.:| ..||   ..|.:        :||||:.|:..|.|.:.|:::||::|
Worm   638 ------KEIPIATNATEF-ADRL---SRETI--------RDAYSVFGLRSDCSDDDIKRNYKRLA 684

  Fly   733 VLVHPDKNKQAGAEEAFKVLQRAFELIGEPENRLIYDQSIAETLHTEKAWTELHDLLSQLQTKMA 797
            .||.|||.....|::.::::..||..||..::|..|   ..|.|...:...:|..:.:.:...:.
Worm   685 ALVSPDKCTIDAADQVYELVDVAFSAIGYKDSRSEY---TLENLKNNEVHEQLISVWNDMTKAVE 746

  Fly   798 EAANTIRCSTCAQRHPRKLTERPHYAARECASCKIRHSAKDGDIWAETSMMGLRWKYLALMDGKV 862
            ||.|||.|. |...|.|..|......||.|..|.::|.||..|||.|...:||...|....|..|
Worm   747 EARNTIFCD-CENTHFRVATSISPSQARSCKRCGVKHPAKQNDIWVEKRHLGLTSTYYTCTDNVV 810

  Fly   863 YDITEWANC--QKGALSHLEPNSHMVQYRIV 891
            ||||.||.|  |:..|.::..::|.||||::
Worm   811 YDITSWATCKSQRAMLKNMRAHTHNVQYRLL 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14650	NP_649473.1	DnaJ	708..769	CDD:278647	22/60 (37%)
CG14650	NP_649473.1	Jiv90	802..891	CDD:291562	37/90 (41%)
dnj-5	NP_495400.2	DnaJ	660..709	CDD:99751	18/48 (38%)
dnj-5	NP_495400.2	Jiv90	751..840	CDD:291562	36/89 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I5920
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I3299
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004260
OrthoInspector	1	1.000	-	-		oto19509
orthoMCL	1	0.900	-	-		OOG6_110132
Panther	1	1.100	-	-	LDO	PTHR44665
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8715
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.080