DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14650 and AgaP_AGAP002386

DIOPT Version :9

Sequence 1:	NP_649473.1	Gene:	CG14650 / 40566	FlyBaseID:	FBgn0037252	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	XP_312569.5	Gene:	AgaP_AGAP002386 / 1273576	VectorBaseID:	AGAP002386	Length:	1078	Species:	Anopheles gambiae

Alignment Length:	1102	Identity:	401/1102 - (36%)
Similarity:	543/1102 - (49%)	Gaps:	203/1102 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PHTDEVGNYLAHQQQQQQQQQHQHQTQNYLIHQQ-----QH---GQAPVPLMWPPPPPH------ 73
            ||     :|.||.|.|..||.||...|..::..|     ||   ....||::.|...|:
Mosquito    26 PH-----HYAAHAQHQFHQQLHQTLLQQPVVPPQLLPHPQHLSYAVPTVPVVAPSGAPYYHGAAG 85

  Fly    74 ------LAGPPFAPHLQQQQPHMYNEY------LFNLSYSGQPGQPETYSV---LPVGPGNFLKV 123
                  .:|..|:.|....|| :.:||      ...:.|  ||.|.:..:|   ....||.....
Mosquito    86 MVDGYGASGTGFSMHHGAHQP-LEDEYSDAYGQAIKVVY--QPQQHQASAVTAAAAAAPGMMPCA 147

  Fly   124 YHCPD-NQV--SEAGTPLFTH--------------INMASINHHQLQHQHQAAPPTPSQPTPLYE 171
            ...|: |.|  .:.|..||::              ::.......|.|.|.|..|....||...:.
Mosquito   148 QEDPNQNHVVQDKQGYELFSNNSSFMLAAPGFGFTLHNPQQQQQQQQQQQQEQPQQQQQPMSQFS 212

  Fly   172 LFATNPLTLPHAQQQDAQHRQPQQTQTQAPTVSQVNHSSSSANLLINNLVNNWSPNLT-----GG 231
            ..:|.|..:.|..|| |....||.|.:|  |:...|:|:||   ||:.||.||:|.::     |.
Mosquito   213 SMSTPPAQVTHPTQQ-AAAPVPQATTSQ--TLENGNNSTSS---LISQLVGNWAPTISGTYGNGP 271

  Fly   232 SYIQFDG-----------EANEMDVVLETSIAQQPQVPNQNLQQPEPLSQSV--NTLPAASKPAK 283
            |.:..|.           |.|....|..|.:|....|.|       |::.:|  ....|...|:.
Mosquito   272 SSLVNDAPSQSVGNPPVQEDNSKATVSPTKVAFSKPVIN-------PVTPNVIGTASQAHGSPSS 329

  Fly   284 SLKMPLATATVSPTAINKSSVAVPGQPEG------------KKRIVAEVKPMPMSYSDVLSK--- 333
            |   |.....||....|.::.||..|...            |:|||||||||.|||||||||
Mosquito   330 S---PSVVPAVSSNRNNTNAAAVYNQQNDDNSAKLDQNVNKKQRIVAEVKPMRMSYSDVLSKNVP 391

  Fly   334 -GTKPSAA------------------GRDMRADNG--GDYSVQSQRRPEKEDAYGNREMRTSKRS 377
             |..|.|:                  |..:.:.||  |....:|:|..::.:|.|.|:...:..:
Mosquito   392 SGGNPFASNASTNGEMVSALPATFGNGTKVSSGNGPNGGSGGKSKRESKRSNANGERKSMGNAGN 456

  Fly   378 PLHDAKET---------------------------GSFVPGVGHAHAS----RGKKRSKVSQTAP 411
            ..| ||:.                           ||..|..|.|.|:    :.|.|:|..:|:.
Mosquito   457 VTH-AKDRANDGSTRKADRTNGAGTGTNSPTMTDGGSSKPMEGSADATQRSGQEKGRNKSDKTSG 520

  Fly   412 LKVQQS--QSLAQPNLQ---PQIKSNKLNNPEKKRPLQPKNVNSNAPKFSEHKTTPVSANSSLQN 471
            :|..:.  :|.|: .|:   .:.:|...:|.::...||....::.:...:..:|.........:.
Mosquito   521 VKRDKGGLRSGAE-GLETGGKKGRSGTHSNEDEAGGLQNCRSDATSAPLANDETEEERGEDYEEY 584

  Fly   472 HSNVLNFTPATNSSTSSRKSGSNKINSNASH----------SNHTGAN-THAGSSSSSSSVNYSS 525
            .|:..:.....:|.||.|:....:....|.|          .|..||| ||....:...:...::
Mosquito   585 DSDEYDQVSIGSSETSGRQDKQQQQQHQAGHEELPFLYNVKKNTNGANDTHIEKINPPRTATATT 649

  Fly   526 NNNVSSSSAKRYSSSNLNPNNSSG-YSYSSKRN-RSNAYSSTNSPTHANSFSSNRNYELAKRIIH 588
            :.......:.|  :....|:.|.| :..|.||: ||.               .|:.|...::::.
Mosquito   650 HRKGGGGRSAR--APGKQPDKSVGNHQASGKRSVRSR---------------KNQKYAFLEKLLL 697

  Fly   589 TWWIYTLKLLTWLFYLVYDIVVLGFSMGYERITLAYVAALAYARQLQKELKQNSGKPSIWWRSYW 653
            .|..||:..|.||:.||.|:|.|...:.::.:..||.....:...::::..:|||:|..|:|..|
Mosquito   698 KWLEYTMLALHWLWSLVSDVVYLSARLAWDYVLSAYQYCRQHVHTIRQDFGKNSGRPGAWFRRAW 762

  Fly   654 RRFDARFAKNSRLAVWRLFYKRK---PPETTSEQFKTGRLPQTGEEAMYSLLNCKGKDAYSILGV 715
            :.||..|||.||.|.||...|:|   ||...|..::.||||.|.:|||.||||||||||||||||
Mosquito   763 QSFDGHFAKESRWAFWRRCRKQKPAEPPGGKSTPYRDGRLPSTADEAMSSLLNCKGKDAYSILGV 827

  Fly   716 PPDSSQEQIRKHYKKIAVLVHPDKNKQAGAEEAFKVLQRAFELIGEPENRLIYDQSIAETLHTEK 780
            .||.|||||||||||||||||||||||.|||||||||||:||||||||:|..||||:||.|:.||
Mosquito   828 SPDCSQEQIRKHYKKIAVLVHPDKNKQPGAEEAFKVLQRSFELIGEPESRKEYDQSLAEALNAEK 892

  Fly   781 AWTELHDLLSQLQTKMAEAANTIRCSTCAQRHPRKLTERPHYAARECASCKIRHSAKDGDIWAET 845
            ||:|::|||:||.||::|||||||||:|..|||||.|.|.|||||||:||||||.|::|||||||
Mosquito   893 AWSEINDLLTQLHTKISEAANTIRCSSCCLRHPRKPTGRAHYAARECSSCKIRHPAREGDIWAET 957

  Fly   846 SMMGLRWKYLALMDGKVYDITEWANCQKGALSHLEPNSHMVQYRIVRGAQQQQQQQQQQQQQQQQ 910
            |.:||||||||:|:|.||||||||||||||||||:||||:||||||.|:..|||||||||||.|.
Mosquito   958 SFLGLRWKYLAMMEGNVYDITEWANCQKGALSHLQPNSHIVQYRIVLGSSSQQQQQQQQQQQHQP 1022

  Fly   911 QHH--QHPQQPHHDRGVHHPGGGVSGVSEATLHEFLDNLYSGQHPGAHNAFAGNARRRTRRN 970
            ||.  |...:....|....|     ..:|..|.:||:|:|:||:..|.:..| ::|||.|||
Mosquito  1023 QHQAGQPLDKDQIGRSRKEP-----TANEPNLDDFLNNIYAGQNQQASSQNA-SSRRRYRRN 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14650	NP_649473.1	DnaJ	708..769	CDD:278647	53/60 (88%)
CG14650	NP_649473.1	Jiv90	802..891	CDD:291562	71/88 (81%)
AgaP_AGAP002386	XP_312569.5	DnaJ	820..881	CDD:278647	53/60 (88%)
AgaP_AGAP002386	XP_312569.5	Jiv90	914..1003	CDD:291562	71/88 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	172	1.000	Domainoid score	I7701
eggNOG	1	0.900	-	-		E1_KOG0720
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	521	1.000	Inparanoid score	I2899
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1173544at2759
OrthoFinder	1	1.000	-	-		FOG0004260
OrthoInspector	1	1.000	-	-		oto108622
Panther	1	1.100	-	-	LDO	PTHR44665
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4060
TreeFam	1	0.960	-	-
	11	10.930