DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14650 and Dnajc14

DIOPT Version :9

Sequence 1:	NP_649473.1	Gene:	CG14650 / 40566	FlyBaseID:	FBgn0037252	Length:	970	Species:	Drosophila melanogaster
Sequence 2:	NP_446142.2	Gene:	Dnajc14 / 114481	RGDID:	620489	Length:	703	Species:	Rattus norvegicus

Alignment Length:	707	Identity:	174/707 - (24%)
Similarity:	267/707 - (37%)	Gaps:	201/707 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 SPLHDAKETGSFVPGVGHAHASRGKKRSKVSQTAPLKVQQSQSLAQPNLQPQIKSNKLNNPEKKR 441
            |.|.|:|||           |..|        |..||........||. .|...|:..:.| .:.
  Rat    37 SGLRDSKET-----------APNG--------TRCLKEHSDPKCTQPP-NPAHWSDPSHGP-PRG 80

  Fly   442 PLQPKNVNSNAPKFSEHKTTPVSANSSLQNHSNVLNFTPATNSSTSSRKSGS-------NKINSN 499
            |..|:  ....|..||..:.....:..|           :..:.|..::.||       :..|..
  Rat    81 PGPPR--EGGYPDESETCSEESGVDQEL-----------SRENETGYQEDGSPSFLPIPSACNCQ 132

  Fly   500 ASHSNHTGANTHAGSSSSSSSVNYSSNNNVSS-----------------SSAKRYSSSNLNPNNS 547
            .|.....|..:..|..||||..::.::..:..                 |...|.||....|:..
  Rat   133 GSPGVPEGTCSEEGDGSSSSFCHHCTSPALGEDEELEEEYDDEEPLKFPSDFSRVSSGKKPPSRR 197

  Fly   548 SGYSYSSKRN-RSNAYSSTNSPTHANSFSSNRNYELAKRIIHT---------------------- 589
            ..:.:.:|.: |.:......:|         ..:.||::...|
  Rat   198 QRHRFLTKEDVRDSGRRDPKAP---------GRHRLARKRSQTDKRRGLGLWGVEELCQLGQAGF 253

  Fly   590 WWIYTLKLLTWLF-----YLVYDIVVL-GFSMGYERITLAYVAAL--AYARQLQKELKQN----- 641
            ||:..|.:|...:     ||:|....| |..:...||.:...|..  .:||.:.:.|.|:
  Rat   254 WWLIELLVLVGEYVETCGYLIYACRKLKGSDLDLFRIWVGVWARRLGGWARVMFQFLSQSFFSVA 318

  Fly   642 ---------------------SGKPSIWWRSY--------WRRFDA---------------RFAK 662
                                 .|...:.||..        ||...|               ...|
  Rat   319 GLFIRLLRVVGAFLLLALALFLGCLQLGWRFLVGLGDRLGWRGKAAWLFSWLDSPALHHFLTLLK 383

  Fly   663 NSRLAVWRL-------------FYKRKPPETTSEQFKTGRLPQTGEEAMYSLLNCKG-----KDA 709
            :||  .|:.             :.|::.....:....:||..|. ||.:..||...|     .:.
  Rat   384 DSR--PWQQLVRVIQWGWLELPWVKQRTQRQGTAHVASGRYCQP-EEEVARLLTMAGVPEDELNP 445

  Fly   710 YSILGVPPDSSQEQIRKHYKKIAVLVHPDKNKQAGAEEAFKVLQRAFELIGEPENRLIYD-QSIA 773
            :.:|||...:|..:::|.|:::||:||||||....||||||||:.|::::..||.|..|: :.:|
  Rat   446 FHVLGVEATASDIELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNPERRKEYEMKRMA 510

  Fly   774 ETLHTEKAWTELHDLLSQLQTKMAEAANTIRCSTCAQRHPRKLTERPHYAARECASCKIRHSAKD 838
            |    .:....:::.||:||..:.||.||:.||.|..:|.|...:|...:||.||.|...|.|::
  Rat   511 E----NELSRSVNEFLSKLQDDLKEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEE 571

  Fly   839 GDIWAETSMMGLRWKYLALMDGKVYDITEWANCQKGALSHLEPNSHMVQYRIVRGAQQQQQQQQQ 903
            ||.|||:||:||:..|.||||||||||||||.||:..:|   |::|.|.|.|..|::......:|
  Rat   572 GDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGIS---PDTHRVPYHISFGSRVPGTSGRQ 633

  Fly   904 QQQQQQQQHHQHPQQPHHD------RGVHHPGGGVSGVSEATLHEFLDNLYSGQHPG 954
            :..         |:.|..|      |....|.|.:|.          .|.::..|||
  Rat   634 RAT---------PESPPADLQDFLSRIFQVPPGPMSN----------GNFFAAPHPG 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14650	NP_649473.1	DnaJ	708..769	CDD:278647	26/60 (43%)
CG14650	NP_649473.1	Jiv90	802..891	CDD:291562	45/88 (51%)
Dnajc14	NP_446142.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..150		29/146 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..229		10/73 (14%)
		DnaJ	444..505	CDD:278647	26/60 (43%)
		Jiv90	535..621	CDD:291562	45/88 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..643		4/29 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	659..703		5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6806
eggNOG	1	0.900	-	-		E1_KOG0720
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004260
OrthoInspector	1	1.000	-	-		oto97164
orthoMCL	1	0.900	-	-		OOG6_110132
Panther	1	1.100	-	-	LDO	PTHR44665
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4060
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.860