DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF3a and RPG1

DIOPT Version :9

Sequence 1:	NP_649470.2	Gene:	eIF3a / 40563	FlyBaseID:	FBgn0037249	Length:	1140	Species:	Drosophila melanogaster
Sequence 2:	NP_009635.1	Gene:	RPG1 / 852371	SGDID:	S000000283	Length:	964	Species:	Saccharomyces cerevisiae

Alignment Length:	1058	Identity:	288/1058 - (27%)
Similarity:	488/1058 - (46%)	Gaps:	218/1058 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RPENALKRANEFIEVGKPLRALDTLQEVFRNKRWNYAYSETVIEPLMFKYLYLCVELKKSHIAKE 71
            |||||:|||:|.|.||:...||.:|.:....:|..:|...|| ||::||:|.:.|||||..:.|:
Yeast     7 RPENAIKRADELISVGEKQAALQSLHDFITARRIRWATPSTV-EPVVFKFLEIGVELKKGKLLKD 70

  Fly    72 GLFQYRNMFQ-----LVNVNSLENVIRGYL-----KMAEEHTEAAQAQSSAAVAVLEL-DDLDNI 125
            ||.||:.:.|     ||:|.:   |.|.::     |:|.|.|.|.:.|..      |: |||:..
Yeast    71 GLHQYKKLIQGSTEGLVSVGA---VARKFIDLVESKIASEQTRADELQKQ------EIDDDLEGG 126

  Fly   126 ATPESILMSAVCGEDAQDRSDRTI-------LLPWVKFLWESYCQCLELLRVNTHCEALYHDIAR 183
            .|||::|:|..       .||:::       :..|::|.||||...|:|||.|...|..|..:.:
Yeast   127 VTPENLLISVY-------ESDQSVAGFNDEAITSWLRFTWESYRAVLDLLRNNALLEITYSGVVK 184

  Fly   184 MAFQFCLKYNRKSEFRRLCDKLRKHLE----DICKSSNQTTGVSINKVETQQLCLDTRLYLLDSA 244
            ....|||||.||:||:||.:.||:||:    ...||.|..  |.::..:|.|..||.|...:|.:
Yeast   185 KTMHFCLKYQRKNEFKRLAEMLRQHLDAANYQQSKSGNNL--VDLSDADTLQRYLDQRFQQVDVS 247

  Fly   245 IQMELWQEAYKAIEDIHGLMALSKKTPVPKTMANYYQKLAMVFSKAGNQLFHAAALLKLFQLTRE 309
            :::|||.|||::|||:..||.:||:.|.|.|:||||:.|..||..:|:.|.|..|..|.::| ..
Yeast   248 VKLELWHEAYRSIEDVFHLMKISKRAPKPSTLANYYENLVKVFFVSGDPLLHTTAWKKFYKL-YS 311

  Fly   310 LKKNLTKDDLQRMAAHVLLATLSIPLPSAHPEFDRFIEADKSP---LEKAQKLAVLLGLPQPPTR 371
            .....|:::.:..::.:.|:.:|..|             |:.|   .:...::..||.|...|||
Yeast   312 TNPRATEEEFKTYSSTIFLSAISTQL-------------DEIPSIGYDPHLRMYRLLNLDAKPTR 363

  Fly   372 VSLIREVVR-LNVPQLVSEDFRNLYNWLEVDFNPLNLCKRIQSIVDFIENGPENALL-------- 427
            ..:::.::. .::...|.|:.:.||:.:||:|:           ||.::...||.|:
Yeast   364 KEMLQSIIEDESIYGKVDEELKELYDIIEVNFD-----------VDTVKQQLENLLVKLSSKTYF 417

  Fly   428 TPYIQSLKDVTIMRLIRQISQVYESIKFQRLLQLASF-----CNIFELEKLLVESVRHNDMQIRI 487
            :.||..|:||.:.|:....||.:.::....|.:||:.     .:.:::||.|:::...:.:.|.|
Yeast   418 SQYIAPLRDVIMRRVFVAASQKFTTVSQSELYKLATLPAPLDLSAWDIEKSLLQAAVEDYVSITI 482

  Fly   488 DHQKNSIYFGTD-------------------LTESQREYRPDGPALQSMPSEQ------------ 521
            ||:...:.|..|                   ..|.|.|......||....:|.
Yeast   483 DHESAKVTFAKDPFDIFASTASKEVSEEENTEPEVQEEKEETDEALGPQETEDGEEKEEESDPVI 547

  Fly   522 -----IRSQLVNMSTVLTRAVSIVYPNRERDQRAKLRNQMVNHYHEIKDREHQRILQRQKIIEDR 581
                 |.::|:.:|.||                     ..|:.::.....|..|| .|:.:|:..
Yeast   548 IRNSYIHNKLLELSNVL---------------------HDVDSFNNASYMEKVRI-ARETLIKKN 590

  Fly   582 KEYIEKQNNAREEEEARRQEE----------------ESRKAKLAEQK-----RLEQEQEERERK 625
            |:.:||.:...:|...|.||:                |.|:.::.|:|     :||:|...|..:
Yeast   591 KDDLEKISKIVDERVKRSQEQKQKHMEHAALHAEQDAEVRQQRILEEKAAIEAKLEEEAHRRLIE 655

  Fly   626 RHQNEIQAIREKSLKEKVQQISQTAHGKKMLSKLDEEGIKKLDAEQIAKRESEELQREAKELQSK 690
            :.:.|.:||:|:.:.:.:.:::...|     ..:|....|.||.:.|.:....|:.:...||:|:
Yeast   656 KKKREFEAIKEREITKMITEVNAKGH-----VYIDPNEAKSLDLDTIKQVIIAEVSKNKSELESR 715

  Fly   691 LKSQEKKIDYFERAKRLEEIPLFEKYLAEKQVKDKEFWEATEKTRIENAIAERKDAVAQQERLKR 755
            ::...||:|:.|||.|..|:||.:|.:.:.|..|...:||.:|..::.|.||.:..:|.::.|..
Yeast   716 MEYAMKKLDHTERALRKVELPLLQKEVDKLQETDTANYEAMKKKIVDAAKAEYEARMADRKNLVM 780

  Fly   756 MYPDRDEFLEAL----KKERASLYVEKLKKFEAA----LEAERKKRLADRIIRRREERRQAFLRE 812
            :|.|..:|.|.:    :.|.|::..:|..:.|||    :|..||:|..:.|.||:||...|
Yeast   781 VYDDYLKFKEHVSGTKESELAAIRNQKKAELEAAKKARIEEVRKRRYEEAIARRKEEIANA---- 841

  Fly   813 KEEERLRKEEEIRLAQAAEERAAAEARRLEREAED--EKRRAQYEKQRAKEEE-------AERKI 868
               ||.::.:|:           |||.|.:||.|:  .|:...|..:....|.       .:..:
Yeast   842 ---ERQKRAQEL-----------AEATRKQREIEEAAAKKSTPYSFRAGNREPPSTPSTLPKATV 892

  Fly   869 KEDRDRLSRELASERERTE--KDRDTWRPRGGDRPSASNGGSSEWRRAAPA--ASERNDRGGERI 929
            ..|:.:|......:||..|  :.|...|..||..|:..         |.||  |:.....|.:::
Yeast   893 SPDKAKLDMIAQKQREMEEAIEQRLAGRTAGGSSPATP---------ATPATPATPTPSSGPKKM 948

  Fly   930 ERGGERIERGGERLERGG 947
            .. .|::.  .:||.:||
Yeast   949 TM-AEKLR--AKRLAKGG 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3a	NP_649470.2	PAM	429..>497	CDD:214803	18/72 (25%)
RPG1	NP_009635.1	PINT	419..>495	CDD:214509	19/75 (25%)
RPG1	NP_009635.1	DUF5401	<595..>862	CDD:375164	78/289 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346669
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2072
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2779
Inparanoid	1	1.050	331	1.000	Inparanoid score	I423
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54611
OrthoFinder	1	1.000	-	-		FOG0003667
OrthoInspector	1	1.000	-	-		oto100047
orthoMCL	1	0.900	-	-		OOG6_102668
Panther	1	1.100	-	-	LDO	PTHR14005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R376
SonicParanoid	1	1.000	-	-		X3031
TreeFam	1	0.960	-	-
	14	13.790