DRSC/TRiP Functional Genomics Resources

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Protein Alignment eIF3a and eif3s10

DIOPT Version :9

Sequence 1:NP_649470.2 Gene:eIF3a / 40563 FlyBaseID:FBgn0037249 Length:1140 Species:Drosophila melanogaster
Sequence 2:NP_956114.2 Gene:eif3s10 / 327515 ZFINID:ZDB-GENE-030131-5726 Length:1267 Species:Danio rerio


Alignment Length:1303 Identity:550/1303 - (42%)
Similarity:760/1303 - (58%) Gaps:200/1303 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MARYTQRPENALKRANEFIEVGKPLRALDTLQEVFRNKR---WNYAYSETVIEPLMFKYLYLCVE 62
            |..|.|||||||||||||:||||...|||.|.:|.::|:   |     :.:.||:|.|||.|||:
Zfish     1 MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVIKSKKHRTW-----QKIHEPIMLKYLELCVD 60

  Fly    63 LKKSHIAKEGLFQYRNMFQLVNVNSLENVIRGYLKMAEEHTEAAQAQSSAAVAVLELDDLDNIAT 127
            |:|||:|||||:||:|:.|.||:.|||:|:|.|||:|||.||.|:.:|..  .||:::|||||.|
Zfish    61 LRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKLAEEKTETAKEESQQ--MVLDIEDLDNIQT 123

  Fly   128 PESILMSAVCGEDAQDRSDRTILLPWVKFLWESYCQCLELLRVNTHCEALYHDIARMAFQFCLKY 192
            |||:|:|||.|||.|||:||.:|.||||||||||.|||:|||.|:..|.||||||:.||:|||:|
Zfish   124 PESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQCLDLLRNNSKVERLYHDIAQQAFKFCLQY 188

  Fly   193 NRKSEFRRLCDKLRKHLEDICKSSNQTTGVSINKVETQQLCLDTRLYLLDSAIQMELWQEAYKAI 257
            .||:|||:|||.||.||..|.:..||:|.:::|..|:|.:.|:|||..|||||.|||||||:||:
Zfish   189 TRKAEFRKLCDNLRMHLGQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSAISMELWQEAFKAV 253

  Fly   258 EDIHGLMALSKKTPVPKTMANYYQKLAMVFSKAGNQLFHAAALLKLFQLTRELKKNLTKDDLQRM 322
            ||||||.|||||.|.|:.|||||.|::.||.|:||.|||:..|.:|:.|:||::||||::::|||
Zfish   254 EDIHGLFALSKKPPKPQLMANYYNKVSTVFWKSGNALFHSCTLHRLYHLSREMRKNLTQEEMQRM 318

  Fly   323 AAHVLLATLSIPLPSAHPEFDRFIEADKSPLEKAQKLAVLLGLPQPPTRVSLIREVVRLNVPQLV 387
            :..|||||||||:.....:..|.::.|...:||.::||.||||..||||.|||.::||.|:.|.|
Zfish   319 STRVLLATLSIPITPERTDIARLLDMDGIIVEKHRRLATLLGLQSPPTRQSLINDMVRFNLLQYV 383

  Fly   388 SEDFRNLYNWLEVDFNPLNLCKRIQSIVDFIENGPE-NALLTPYIQSLKDVTIMRLIRQISQVYE 451
            ..:.:.|||||||||:||.||.|:..:::::.:..| .:.|..|:..|::.||:||::|::|:|:
Zfish   384 VPEVKELYNWLEVDFHPLKLCGRVTKVLNWVRDQAEKESDLQQYVPHLQNNTILRLLQQVAQIYQ 448

  Fly   452 SIKFQRLLQLASFCNIFELEKLLVESVRHNDMQIRIDHQKNSIYFGTDLTESQREYRPDGPALQS 516
            ||:|.||..|..|.:.|:||:.:|::.||.|:|:||||...::.||:||..|.:|..|.||.||:
Zfish   449 SIEFSRLASLVPFVDAFQLERSIVDAARHCDLQVRIDHSSRTLSFGSDLNYSTKEDSPVGPFLQN 513

  Fly   517 MPSEQIRSQLVNMSTVLTRAVSIVYPNRERDQRAKLRNQMVNHYHEIKDREHQRILQRQKIIEDR 581
            |||||||:||..||:.|.:|:.::.|........:.|.|.:..|.:...:||||||.|::.||:|
Zfish   514 MPSEQIRNQLTAMSSSLAKAIQVIKPASILQDHEEQRQQAITAYLKNARKEHQRILARRQTIEER 578

  Fly   582 KEYIEKQNNAREEEEARRQEEESRKAKLAEQKRLEQEQEERERKRHQNEIQAIREKSLKEKVQQI 646
            ||.:|..|..||:||..::|.|.:|.:.||::||.||.:|||::|...|.:.|::|:::|:::||
Zfish   579 KERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERIMQEHEQIKKKTVRERLEQI 643

  Fly   647 SQTAHGKKMLSKLDEEGIKKLDAEQIAKRESEELQREAKELQSKLKSQEKKIDYFERAKRLEEIP 711
            .:|..|.|....:|.|.:::||.:.|..::.|:|::|.||||.:||:||||||||||||||||||
Zfish   644 KKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIP 708

  Fly   712 LFEKYLAEKQVKDKEFWEATEKTRIENAIAERKDAVAQQERLKRMYPDRDEFLEALKKERASLYV 776
            |.:|...|:::||.|.||..|:.||.|...||:.|:..::|:.||..|::.||..:|..|:.:|.
Zfish   709 LIKKAYEEQRIKDMELWELQEEERITNMKMEREKALEHKQRMSRMMEDKENFLSKIKAARSFIYE 773

  Fly   777 EKLKKFEAALEAERKKRLADRIIRRREERRQAFLREKEEERLRKEEEIRLAQAAEERAAAEARRL 841
            ||||:|:..|..||||||.:|..:|:|:||:||..:||||..|..|| :|.:..|||     .||
Zfish   774 EKLKQFQERLVEERKKRLEERKKQRKEDRRKAFYHQKEEEAQRIREE-QLKKEREER-----ERL 832

  Fly   842 EREAEDEKRR----------AQYEKQRAKEEE-AERKIKEDRDRLSRELASERERTEKDRDTWRP 895
            |:|..:|:.|          .|..||||:::| .||:.:::.:|.:.|....:|..|::...||.
Zfish   833 EQEQREEEEREYQERLRKLDEQERKQRARQQEIEERERRKEEERRAPEEKPNKEWAEREESGWRK 897

  Fly   896 RGGDRPSASNGGSSEWRRAAPAASERND------------------RGGERIERG---------- 932
            ||        .|.|||||..|....|.:                  ||||...||          
Zfish   898 RG--------EGESEWRRPVPDRDWRQEGREGREEPDREDRDLPFRRGGESARRGASDEKGLRRG 954

  Fly   933 -----GERIERGG--ERLERGG-------------ERIERGGDRDRKDNEGADSSWRVRREPDSQ 977
                 |.|  |||  ||..|.|             :|.:|.||.||....|.|.....||..|..
Zfish   955 CDDDRGPR--RGGDDERPPRRGFDDDRGTRRGFDDDRGQRRGDDDRGPRRGMDDDRGPRRPIDDD 1017

  Fly   978 RAAAPKDS----------------------GAPQSRDDKW--RRGGERDRDFRIDGARRDRDD-G 1017
            |.....|.                      |..:..||.|  ||||:.:|     |.||..|| |
Zfish  1018 RGPRRSDDDRGPRRGFDDDRGPRRGMDEPRGPRRGADDDWGPRRGGDDER-----GGRRGMDDSG 1077

  Fly  1018 PRRDR------------------------------------DDGPRRDRDDERGG--FRRADGAR 1044
            |||..                                    |||..||.||:|.|  ||....||
Zfish  1078 PRRGEDSRPWKPLGRPGAGGWREREKAREESWGPPRDSGHDDDGGERDGDDQREGERFRERRSAR 1142

  Fly  1045 RTDEPQRETGG---------NWRDAPRH-ADRETRRP----AERRDRDVRETRGDQRGSAPKEAA 1095
            ......|..||         :|||:.|. .|||.||.    .||||...|:.||.||..      
Zfish  1143 EEGSAWRRGGGGGGGGEEQSSWRDSRREDFDREDRRERRDMRERRDDRERDIRGPQRDQ------ 1201

  Fly  1096 SGGVGGNWRTAPATREEKPAAKRD---QAQEKENKAG---------------------DDGEWTS 1136
              ..||:||.....|.|:...:||   :.:|::..:|                     ||..||:
Zfish  1202 --DEGGSWRRGGEERREERKEERDAPPRPRERDRDSGEKSTWRSDKDKENPRRTKNETDDDGWTT 1264

  Fly  1137 VKR 1139
            |:|
Zfish  1265 VRR 1267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eIF3aNP_649470.2 PAM 429..>497 CDD:214803 28/67 (42%)
eif3s10NP_956114.2 PAM 426..498 CDD:214803 31/71 (44%)
Taxilin 517..800 CDD:286771 124/282 (44%)
GBP_C <566..685 CDD:303769 48/118 (41%)
DUF342 <643..739 CDD:302792 48/95 (51%)
coiled coil 650..661 CDD:293879 3/10 (30%)
coiled coil 674..685 CDD:293879 5/10 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 792..1267 143/503 (28%)
12 X 10 AA approximate tandem repeats of D-[DE]-[DE]-R-[GP]-[GPQT]-R-R-[GPS]-[ADFGIM] 956..1073 34/123 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170596430
Domainoid 1 1.000 436 1.000 Domainoid score I547
eggNOG 1 0.900 - - E1_KOG2072
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2779
Inparanoid 1 1.050 937 1.000 Inparanoid score I339
OMA 1 1.010 - - QHG54611
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003667
OrthoInspector 1 1.000 - - oto40395
orthoMCL 1 0.900 - - OOG6_102668
Panther 1 1.100 - - LDO PTHR14005
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R376
SonicParanoid 1 1.000 - - X3031
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1514.790

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