DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment srl and Ppargc1a

DIOPT Version :9

Sequence 1:	NP_649469.2	Gene:	srl / 40562	FlyBaseID:	FBgn0037248	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	XP_038948416.1	Gene:	Ppargc1a / 83516	RGDID:	620925	Length:	831	Species:	Rattus norvegicus

Alignment Length:	945	Identity:	208/945 - (22%)
Similarity:	335/945 - (35%)	Gaps:	254/945 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 EVDALGLS-IDVNNFDLADFITKDDFAENLNACRKKESLQAQAQIKSNTLADVPILLNPPVATIV 264
            ::..|.|| :|||:.|      .|.|...|..|      ..|::|.||...:.|       |.|.
  Rat    33 DLPELDLSELDVNDLD------TDSFLGGLKWC------SDQSEIISNQYNNEP-------ANIF 78

  Fly   265 AKPGVPSSKPG------------------------DSDYDSDSI-IDVETVDVLDMNMANIWSID 304
            ......:.:.|                        |.:.:::.: :..||:|.|.::...:.|.|
  Rat    79 EGTCYSNKESGKFERSRRSGFVQNYLTKENMFKKIDEENEANLLAVLTETLDSLPVDEDGLPSFD 143

  Fly   305 KPAKMGQTPDELRYVDNVKADPSWSPRSAKKTTPTIKENKPEQLGNHQLAVPASNKPKHKNICLV 369
            ....           .:|..|...||.|....||..:|.:...|....|..||:.:..:.....:
  Rat   144 ALTD-----------GDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGL 197

  Fly   370 PNKKQCDFLKRKVGSPSLSKLTKATTKKATESMSNKQPSVKNTQCTGLGLGGKNLSLLK------ 428
            ..:...:...|...:|::.|...:.:.||......::|  :...|:         .|||
  Rat   198 STQNHANHTHRIRTNPAIVKTENSWSNKAKSICQQQKP--QRRPCS---------ELLKYLTTND 251

  Fly   429 --------QERDAALSVCAAK------------PIAPPTLSTTTPTLTP---------PAKRKLN 464
                    :.|:::...||:|            ...|.|||.   .|||         |.:.| .
  Rat   252 DPPHTKPTENRNSSRDKCASKKKSHTQPQSQHAQAKPTTLSL---PLTPESPNDPKGSPFENK-T 312

  Fly   465 LEEYKQRRCGGVGAVYPKPTPPKQA----------KIEVAAKRIAPTPVSKPTPSPKKAEIVNIV 519
            :|........|...:.|..|||.:|          |::.:.|.:.|.|..:...|
  Rat   313 IERTLSVELSGTAGLTPPTTPPHKANQDNPFKASPKLKPSCKTVVPPPTKRARYS---------- 367

  Fly   520 NSLKCPRT----------EQSSLPMDPITMAKNKVLRMLEMKRAQQLKIIDSRVSAKVPRVTKLP 574
               :|..|          |||.|...   ::|:.||     .|..:            .|.||.|
  Rat   368 ---ECSGTQGSHSTKKGPEQSELYAQ---LSKSSVL-----SRGHE------------ERKTKRP 409

  Fly   575 PLKDIVKDTYCMETEDPGTEIAPLSNKLHPDYEEIIIVSASC--------NTDITIPPNQLSKAS 631
            .|:......||.........:..:|.:|. |..::....|||        :||       .|:..
  Rat   410 SLRLFGDHDYCQSVNSKTDILINISQELQ-DSRQLDFKDASCDWQGHICSSTD-------SSQCY 466

  Fly   632 PRSLLKSSVLLYNISNGQDANKNMSNSLIASIQSEVARQTSNTTLSTIQSNATKVMSSADKNCQH 696
            .|..|::|..:...|    ..|.:.:.   .|::|:.:...:.:.:.......|.....|.|
  Rat   467 LRETLEASKQVSPCS----TRKQLQDQ---EIRAELNKHFGHPSQAVFDDKVDKTSELRDGN--- 521

  Fly   697 GEDMVIMHLPKDRVRKTLVSIATQTDLQPEFPLLTLPPKRQSRERTRRNYRRRRTQG-SGSNMST 760
                    ...::..|..|.|.:...:...|       .....|..:.:|....||. |..::|.
  Rat   522 --------FSNEQFSKLPVFINSGLAMDGLF-------DDSEDENDKLSYPWDGTQSYSLFDVSP 571

  Fly   761 SSSDFSSDCSSLVS----------HRSRSQYDSIDQLRNLDVAATCGGSIGNGGYSSRSTQR--- 812
            |.|.|:|.|...||          .|.||:..|..:.|          |.....| |||..|
  Rat   572 SCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHR----------SCSRSPY-SRSRSRSPG 625

  Fly   813 HRSSVSSSSYSENGQYRRRQRRTSYNKRRSRNQKRGSTSSSCSGSEKSDRER-SRSPHRKLRHSR 876
            .|||..|..|.|:..||.|..|.|....|||::...|........|.::.|| .|..:|:....|
  Rat   626 SRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEANEHERLKRDEYRREYEKR 690

  Fly   877 SRSRSKSDTRYPNNNSSSNNNNRRGFFDRNVSQPAVEERRIVYVGRIEQETTKEILRRKFLPYGS 941
            ...|:|...|.                    .|.|:||||::|||:|..:||:..||.:|..:|.
  Rat   691 ESERAKQRERQ--------------------KQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGE 735

  Fly   942 IKQITIHYKENGMKYGFVTYERAQDAFTAIDTSH--RDSQISMYDISFGGRRAFCRSSYADLDNA 1004
            |::.|::.:::|..|||:||....|||.|::..:  |.|..:.:::.|.||:.|.:|:|||||:
  Rat   736 IEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDS- 799

  Fly  1005 GINNYNSYVFPKEAPAPNVVEDSFEALLLQVKAKL 1039
                 ||..|...:.........|::||.:.:..|
  Rat   800 -----NSDDFDPASTKSKYDSLDFDSLLKEAQRSL 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
srl	NP_649469.2	RRM	<906..>975	CDD:223796	28/68 (41%)
srl	NP_649469.2	RRM_PPARGC1A_like	914..1002	CDD:240803	35/89 (39%)
Ppargc1a	XP_038948416.1	RRM_PPARGC1A	708..798	CDD:410034	35/89 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353070
Domainoid	1	1.000	56	1.000	Domainoid score	I10733
eggNOG	1	0.900	-	-		E1_28IAX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4775
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006880
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15528
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.940