DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment srl and ppargc1a

DIOPT Version :9

Sequence 1:	NP_649469.2	Gene:	srl / 40562	FlyBaseID:	FBgn0037248	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	XP_017212627.1	Gene:	ppargc1a / 553418	ZFINID:	ZDB-GENE-080505-1	Length:	885	Species:	Danio rerio

Alignment Length:	973	Identity:	205/973 - (21%)
Similarity:	345/973 - (35%)	Gaps:	253/973 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 EVDALGLS-IDVNNFDLADFI----TKDDFAENLNACRKKESLQAQAQIKSNTLADVPILLNPPV 260
            ::..|.|| :||::.|...|:    ...|.:|.:::....|:.....:|.....|::..:|...:
Zfish    30 DLPELDLSELDVSDLDADSFLGGLKWYSDQSEIISSQYGNEASNLFEKIDEENEANLLAVLTETL 94

  Fly   261 ATI-VAKPGVPSSKPGDSDYDSDSIIDVETVDVLDMNMANIWSIDKPAKMGQTPDELRYVDNVKA 324
            .:| |.:.|:||         .:::.|.:..:..|.:..:            |||
Zfish    95 DSIPVDEDGLPS---------FEALADGDVTNASDQSCPS------------TPD---------- 128

  Fly   325 DPSWSPRSAKKTTPTIKENKPEQLGNHQLAV-----------PASNK-----------PKHKNIC 367
               .|||:.:...|::.:.......|.||:.           .|||:           ..|:..|
Zfish   129 ---GSPRTPEPEEPSLLKKLLLAPANSQLSYNQYPGGKAQNHAASNQRIRPAPAVAKVAAHRTSC 190

  Fly   368 L---------------VPN---KKQCDFLKRKVGSPSLSKLTKATTKKAT--------------E 400
            :               .||   ::.|..|.:.:.|...:..|||...|:|              .
Zfish   191 IKGLTENPWNSKPRGACPNRSMRRPCTELLKYLTSSDEAFQTKAGEAKSTWTGCGKDRGGACISS 255

  Fly   401 SMSNKQPSVKNT-------QCTGLGLGGKNLSLL---KQERDAALSVCAAKP-IAPPTLSTTTPT 454
            ..|:..||..:|       .|:......|..|..   .|::..|:....||| |.|..|:..:|.
Zfish   256 CSSSSSPSSSSTSSFSSLSSCSSSTASKKKTSSASPSSQQQQLAVQAQRAKPTILPLPLTPESPN 320

  Fly   455 -------LTPPAKRKLNLEEYKQRRCGGVGAVYPKPTPPKQAKIEVAAKRIAPTPVSKPTPSPKK 512
                   .....:|.|::|     .||..| :.|..|||.:|..|...|......:|..:||...
Zfish   321 DHKGSPFENKTIERTLSVE-----ICGTPG-LTPPTTPPHKASQENPFKVSLKNKLSSCSPSALT 379

  Fly   513 AEIVNIVNSLKCPRTEQSSLPMDPITMAKNKVLRMLEMKRAQQLKIIDSRVSAKVP------RVT 571
            ::...:.|...||:....|:...|   .:.::...|            |:.|:.:|      |..
Zfish   380 SKRPRLSNGGSCPQPTSGSIRKGP---EQTELYAQL------------SKASSTMPQGGLEDRRG 429

  Fly   572 KLPPLKDIVKDTYCMET---EDPGTEIAPLSNKLHPDYEEIIIVSASCNTDITIPPNQLSKASPR 633
            |.|..:......||..|   .|..|..|.:.......:.|       |. |:.:|.:..:.:|..
Zfish   430 KRPMPRVFGDHDYCQSTSTKRDSTTPAAVVPGPTEGRHVE-------CK-DLNMPTSTTTTSSLS 486

  Fly   634 SLLKSSVLLYNISNGQDANKNMSNSLIASIQ--SEVARQTSNTTLSTIQSNATKVMSSADKNCQH 696
            |...|                 |:||...:|  |...::....|.:.:|.:.:.  |....:|..
Zfish   487 STPPS-----------------SSSLARQLQGLSPTPQEACPDTYAHVQHHDSS--SKMTMDCSS 532

  Fly   697 G----------EDMVIMHLPKDRVRKTLVSIATQTDLQP--------EFPLLT---LPPKRQSRE 740
            |          .|.:..|..|.:.......:......||        |:|.|.   :.|.....|
Zfish   533 GGRKLLRDQEIRDELNKHFGKPQQAFYSGVVGEPRGKQPIEDSDSGDEYPGLLGDYIHPGLPDFE 597

  Fly   741 RTRRNYRRRRTQGSGS----------NMSTSSSDFS----SDCSSLVSHRSRSQYDSIDQLRNLD 791
            .......|....|.||          :.|.|||.||    |..||.:|.:......||.:.|
Zfish   598 DLEVGRERLFYLGEGSPLELLLEGSPSSSPSSSSFSWCSVSPPSSQLSPQHLRWPRSISRSR--- 659

  Fly   792 VAATCGGSIGNGGYSSRSTQRH-RSSVSSSSYSENGQYRRRQRRTSYNKRRSRNQKRGSTSSSCS 855
                           |||:..| |.|:|.|.||.:|....|....|     .||....:.:....
Zfish   660 ---------------SRSSSHHRRRSLSRSPYSRSGSPSSRSPSWS-----PRNMDESTFTPRIC 704

  Fly   856 GSEKSDRER--SRSP----HRKLRHSR-SRSRSKSDTRYPNNNSSSNNNNRRGFFDRNVSQPAVE 913
            |:.:|....  .|.|    :.:.:|.| .|...:.|........:.....:|        |.|:|
Zfish   705 GNPQSQSHSLFGRRPRYDSYEEYQHERLKREEYRRDYEKRECERAEQRERQR--------QKAIE 761

  Fly   914 ERRIVYVGRIEQETTKEILRRKFLPYGSIKQITIHYKENGMKYGFVTYERAQDAFTAIDTSH--R 976
            |||:|||||:..::|:..|:|:|..:|.|::.|::.:.:|..:||:||....||..|::..|  |
Zfish   762 ERRVVYVGRLRADSTRTELKRRFEVFGEIEESTVNLRHDGDNFGFITYRYTCDALAALENGHTLR 826

  Fly   977 DSQISMYDISFGGRRAFCRSSYADLDNAGINNYNSYVFPKEAPAPNVVEDSFEALLLQVKAKL 1039
            .|....:::..||::.:.:|:|.|||:      :|..|...:.........|::||.:.:..|
Zfish   827 RSNEPHFELCLGGQKQYSKSNYTDLDS------HSDDFDPASTKSKYDSMDFDSLLREAQYSL 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
srl	NP_649469.2	RRM	<906..>975	CDD:223796	26/68 (38%)
srl	NP_649469.2	RRM_PPARGC1A_like	914..1002	CDD:240803	31/89 (35%)
ppargc1a	XP_017212627.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595058
Domainoid	1	1.000	62	1.000	Domainoid score	I10324
eggNOG	1	0.900	-	-		E1_28IAX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006880
OrthoInspector	1	1.000	-	-		otm25248
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15528
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5188
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.920