Protein Alignment srl and Ppargc1b

DIOPT Version :10

• Sequence 1: NP_649469.2
• Gene: srl / 40562
• FlyBaseID: FBgn0037248
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: NP_788264.2
• Gene: Ppargc1b / 291567
• RGDID: 727948
• Length: 1010
• Species: Rattus norvegicus
• Alignment Length: 1094
• Identity: 197/1094 - (18%)
• Similarity: 357/1094 - (32%)
• Gaps: 387/1094 - (35%)

  Fly   209 IDVNNFDLADFITKDDFAENLNACRKKESLQAQA---------QIKS----------NTLADVPI 254
            :|::..|.:||.:...|.| |..|.:....:...         ||.|          .||.|:|
  Rat    42 LDLSQLDASDFDSATCFGE-LQWCPETSETEPSQYSPDDSEFFQIDSENEALLAALTKTLDDIP- 104

  Fly   255 LLNPPVATIVAKPGV-----PSSKPGDSDYDSDSIIDVETVDVLDMNMANIWSIDKPAKMGQ--- 311
               .....:.|.||:     ||..|.     |.:.:.|.....|:..::.:..:|:.:.:.:
  Rat   105 ---EDDVGLAAFPGLDEGDTPSCTPA-----SPAPLSVPPSPALERLLSPVSEVDELSLLQKLLL 161

  Fly   312 -TPDELRYVDNVKADPSWSPRSAK---------------KTTPTIK-ENKP-EQLGNHQLAV--- 355
             |.......|.:|...:||..|..               |.||.:: :::| .:|..|..:|
  Rat   162 ATSSPTASSDALKDGATWSQTSLSSRSQRPCVKVDGTQDKKTPMLRSQSRPCTELHKHLTSVLPC 226

  Fly   356 ---PASNKPKHKNICLVPNK-----KQC-----------DFLKRKVGSPSLSKLTKATTK----- 396
               .|.:.|.|.:..|:..:     :.|           |.|.:...:|:.:::.|...:
  Rat   227 PRGKACSPPPHPSPQLLSKEDEEVGEDCPSPWPAPASPQDSLGQDTANPNSAQVPKDDVRAMVQL 291

  Fly   397 ----------------KATESM--------------SNKQPSVKNTQCTGLGLGGKNLSLLKQ-- 429
                            :|:|.:              |.:.|....|:          .|:|::
  Rat   292 IRYMHTYCLPQRKLPQRASEPIPQSCSSPLRKVPPRSRQTPKAFWTE----------FSILRELL 346

  Fly   430 ERDAALSVCAAKPIAPPTLSTTTPTLTPPAKRKLNLEEYKQRRCGGVGAVYPKPTPPKQAKIEVA 494
            .:|....|.....:|.|..:    :|||.::.:                      |||.::...|
  Rat   347 AQDILCDVSKPYRLATPVYA----SLTPQSRTR----------------------PPKDSQASPA 385

  Fly   495 AK------RIAPTPVSK-PTPS--PKKAEIVNIVN------------------------------ 520
            ..      ||..:|.|. |.||  |.:.|:...||
  Rat   386 HSAMAEEVRITASPKSTGPRPSLRPLRLEVKRDVNKPARQKREEDEEEEEEEEEEEEKEDEEEEW 450

  Fly   521 -------------------SLKCP--RTEQSSLPMDP-ITMAKNKVLRMLEMKRAQQLK------ 557
                               |..||  |:.:.:..:.| :|.....:..:..|..|.:..
  Rat   451 GRKRPGRGLPWTKLGRKMDSSVCPVRRSRRLNPELGPWLTFTDEPLGALPSMCLATETHDLEEEL 515

  Fly   558 --IIDSRVSAKVPRVTKLPPLKDIVKDTYCMET-EDPG-----------------TEIAPLSNKL 602
              :.||....::|..:::|.|:... ::.|.:| |||.                 ::..||..|
  Rat   516 GGLTDSSQGQQLPLGSQIPTLESPC-ESGCGDTDEDPSCPRPPSRDSPRCLMLALSQSDPLGKK- 578

  Fly   603 HPDYEEIIIVSASCN----TDITIPPNQLSKASPRSLLKSSVLLYNISNGQDANKNMSNSLIASI 663
              .:||.:.|.. |.    |..|.||.:..:..|..              ||...:.......|:
  Rat   579 --SFEESLTVEL-CGTAGLTPPTTPPYKPMEEDPFK--------------QDTKHSPGQDTAPSL 626

  Fly   664 QSEVARQTSNT----------------TLSTIQSNATKVMSSADK----NCQHGE-DMVIMHLPK 707
            .|....|.:.|                .||.:|...|:.:|.|.:    :|..|: |...:..|:
  Rat   627 PSPETLQLTATPGASHKLPKRHPERSELLSHLQHATTQPVSQAGQKRPFSCSFGDHDYCQVIRPE 691

  Fly   708 DRV-RKTL-------VSIATQTDLQPEFPLLTLPPKRQ-----------SRERTRRNYRRRRTQG 753
            ..: ||.|       |.:..........|:.|..|:|:           |.:......|...|:.
  Rat   692 AALQRKVLRSWEPIKVHLEDLAHQGATLPVETKTPRREADQNCDPTPKDSMQLRDHEIRASLTKH 756

  Fly   754 SGSNMSTSSSDFSSDCSSLVSHRSRSQYDSIDQLRNLDVAATCGGSI-------GNGGYSSRSTQ 811
            .|...:....:..:.|.|       .:||::.:    |.:::.|.|.       ..||  ....:
  Rat   757 FGLLETALEEEDLASCKS-------PEYDTVFE----DSSSSSGESSFLLEEEEEEGG--EEDDE 808

  Fly   812 RHRSSVSSSSYSENGQYRRRQRRTSYNKRRSRNQKRGST-SSSCS----GSEKSDRERSRSP--- 868
            ...|.||... |::..|:....:.|   |:..::.|.|: |||||    .:.|:.|..||.|
  Rat   809 GEDSGVSPPC-SDHCPYQSPPSKAS---RQLCSRSRSSSGSSSCSSWSPATRKNFRLESRGPCSD 869

  Fly   869 -HRKLRHSRSRSRSKSDTRYPNNNSSSNNNNRRGFFDRNVSQPAVEERRIVYVGRIEQETTKEIL 932
             ....||::.| |.|                            |:.|.|:||:..:..:.:...|
  Rat   870 GTPSARHAKKR-REK----------------------------AIGEGRVVYIRNLSGDMSSREL 905

  Fly   933 RRKFLPYGSIKQI-TIHYKENGMKYGFVTYERAQDAFTAI--DTSHRDSQISMYDISFGGRRAFC 994
            :::|..:|.|.:. .:...:.|.|:||:|:..::.|..::  ..:.|......:.:|:||.|.|.
  Rat   906 KKRFEVFGEIVECQVLRRSKRGQKHGFITFRCSEHAALSVRNGATLRKRNEPSFHLSYGGLRHFR 970

  Fly   995 RSSYADLD--------NAGINNYNSYVFPKEAPAPNVVEDSFEALLLQVKAKLN 1040
            ...|.|.|        ::|.:.|.:.              .|::||.:.:..|:
  Rat   971 WPRYTDYDPTSEESLPSSGKSKYEAM--------------DFDSLLKEAQQSLH 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
srl	NP_649469.2	RRM_PPARGC1A_like	914..1002	CDD:409793	22/90 (24%)
Ppargc1b	NP_788264.2	Abolishes DNA transcriptional activity when missing. /evidence=ECO:0000250	1..91		11/49 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..134		5/23 (22%)
		LXXLL motif 1	140..144		1/3 (33%)
		LXXLL motif 2	156..160		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..214		9/48 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	227..282		8/54 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..329		2/22 (9%)
		LXXLL motif 3	342..346		1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	369..475		19/127 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	517..567		10/50 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	590..674		17/97 (18%)
		HCFC1-binding-motif (HBM)	681..684		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	714..744		5/29 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	778..881		28/113 (25%)
		RRM_PPARGC1B	882..978	CDD:409792	24/123 (20%)