Protein Alignment srl and PPRC1

DIOPT Version :10

• Sequence 1: NP_649469.2
• Gene: srl / 40562
• FlyBaseID: FBgn0037248
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: XP_024303683.2
• Gene: PPRC1 / 23082
• HGNCID: 30025
• Length: 1717
• Species: Homo sapiens
• Alignment Length: 1399
• Identity: 285/1399 - (20%)
• Similarity: 458/1399 - (32%)
• Gaps: 525/1399 - (37%)

  Fly    31 NDELQLTDTLSGILPIAPTDESL-------------LNHNREEDLQNR---KNLLIYNDFLKQEL 79
            :|.|:.:..|..::|...::...             |:.|.||.|.:.   |...:....:.:|.
Human   431 DDSLETSSALQLLMPTLESETEAAVPKVTLCSEKEGLSLNSEEKLDSACLLKPREVVEPVVPKEP 495

  Fly    80 SNHDANELNAQVYRSIADSGGEIAYEQQRQISAIVEYDKEDIKIDGLTE--EEDIQSQSTFRTRT 142
            .|..||          |..|.:.|.:.:::.|.    ::....::|...  ....:.|||..|..
Human   496 QNPPAN----------AAPGSQRARKGRKKKSK----EQPAACVEGYARRLRSSSRGQSTVGTEV 546

  Fly   143 DSSSIGDYESHSSDYDDEFDIVNEEKSPR-------LQVVHNNIGNL-----QSSCERKG----- 190
            .|......:....:...|...:..:..||       ..:.:::..||     |||..::|
Human   547 TSQVDNLQKQPQEELQKESGPLQGKGKPRAWARAWAAALENSSPKNLERSAGQSSPAKEGPLDLY 611

  Fly   191 ----RTLSTNTI---ISEVD-----------------ALG------LSIDVNNFDLADFITKDDF 225
                .|:.||.|   :|.||                 |:|      :.:|....|||.  |..:.
Human   612 PKLADTIQTNPIPTHLSLVDSAQASPMPVDSVEADPTAVGPVLAGPVPVDPGLVDLAS--TSSEL 674

  Fly   226 AENLNACRKKESLQAQAQIKSNTLADVPILLNPPVATIVAKPGVPSSKPGDSDYDSDSIIDVETV 290
            .|.|.|                    .|:|:||.:|...|                   :|...|
Human   675 VEPLPA--------------------EPVLINPVLADSAA-------------------VDPAVV 700

  Fly   291 DVLDMNMANIWSIDKPAKMGQTPDELRYVDNVKADPSWSPRSAKKTTPTIKENKP---------E 346
            .:.|    |:..:| ....|..|.:|..||.|       |.......|.:.:::|         .
Human   701 PISD----NLPPVD-AVPSGPAPVDLALVDPV-------PNDLTPVDPVLVKSRPTDPRRGAVSS 753

  Fly   347 QLGNH--QLAVPASNKPKHKNICLVPNKKQ-CDFLKRKVGSPSLSKLTKATTKKA---------- 398
            .||..  ||.|.:.:....|.|  :|..|: .|.||.:.|       |.|||.:|
Human   754 ALGGSAPQLLVESESLDPPKTI--IPEVKEVVDSLKIESG-------TSATTHEARPRPLSLSEY 809

  Fly   399 ----------TESMS-----NKQPSVKNT-------QCTGLGLGGKNLSLLKQERDAALSVC--- 438
                      ||..|     .|.||:..|       .|..:.......:.|::..:..|.:|
Human   810 RRRRQQRQAETEERSPQPPTGKWPSLPETPTGLADIPCLVIPPAPAKKTALQRSPETPLEICLVP 874

  Fly   439 -------------AAKPIA-------------------PPTLSTTTPTLTPPAKRKLNLEEYKQR 471
                         .:||:|                   ||..|.:....|||     ::......
Human   875 VGPSPASPSPEPPVSKPVASSPTEQVPSQEMPLLARPSPPVQSVSPAVPTPP-----SMSAALPF 934

  Fly   472 RCGGVGAVYPKPTPPKQ-AKIEVAAKRIAPTPVSKPTPSPK----------------KAEIVNIV 519
            ..||:|.....|.||.| ..:.::...:.|.|.:...|.|.                ....|.:|
Human   935 PAGGLGMPPSLPPPPLQPPSLPLSMGPVLPDPFTHYAPLPSWPCYPHVSPSGYPCLPPPPTVPLV 999

  Fly   520 N--------------------------SLKC--------PRTEQ----SSLPMDPITMAKNKVLR 546
            :                          |..|        |..:.    |::|..|:..|
Human  1000 SGTPGAYAVPPTCSVPWAPPPAPVSPYSSTCTYGPLGWGPGPQHAPFWSTVPPPPLPPA------ 1058

  Fly   547 MLEMKRAQQLKIIDSRVSAKVP-----RVTKLPPLKDIVKDTYCMETEDPGTEIAPLSNKLHPDY 606
              .:.||.....::||.:...|     .::..|||...:......:||....|:.|:....||.:
Human  1059 --SIGRAVPQPKMESRGTPAGPPENVLPLSMAPPLSLGLPGHGAPQTEPTKVEVKPVPASPHPKH 1121

  Fly   607 EEIIIVSA------SCNT--DITI--------------------PPNQLSKA------------- 630
            :...:|.:      :|.:  .:|:                    ||...:||
Human  1122 KVSALVQSPQMKALACVSAEGVTVEEPASERLKPETQETRPREKPPLPATKAVPTPRQSTVPKLP 1186

  Fly   631 --SPRSLLKSSVLLYNISNGQDANKNMSNSLIASIQSEVARQTSNTTLSTIQSNATKVMSSADKN 693
              .|..|.|.|.|....:.|       |..::.:..||:..:.|:  ||::.....|  |.|.|.
Human  1187 AVHPARLRKLSFLPTPRTQG-------SEDVVQAFISEIGIEASD--LSSLLEQFEK--SEAKKE 1240

  Fly   694 C-------------QHGEDMVIMHLPKDRVR---------------------------------K 712
            |             ..|.|:.....|.||::                                 |
Human  1241 CPPPAPADSLAVGNSGGVDIPQEKRPLDRLQAPELANVAGLTPPATPPHQLWKPLAAVSLLAKAK 1305

  Fly   713 TLVSIATQTDLQPE------------------------------------------FPLLTLPPK 735
            :..|.|.:..|:||                                          .|.|.:|
Human  1306 SPKSTAQEGTLKPEGVTEAKHPAAVRLQEGVHGPSRVHVGSGDHDYCVRSRTPPKKMPALVIP-- 1368

  Fly   736 RQSRERTRRNYRRRR--------TQGSGS---------------NMSTSSSDFSSDC---SSLVS 774
               ...:|.|.:|.:        :.|..:               ..|:..:|.|:.|   |||:|
Human  1369 ---EVGSRWNVKRHQDITIKPVLSLGPAAPPPPCIAASREPLDHRTSSEQADPSAPCLAPSSLLS 1430

  Fly   775 ---------HRSRSQYDSIDQLRNL--------DVAATCGGSIGNGGYSSRS-------TQRHRS 815
                     ..:|:..:...:.|::        ..:.:..|..|..|.:|||       |....|
Human  1431 PEASPCRNDMNTRTPPEPSAKQRSMRCYRKACRSASPSSQGWQGRRGRNSRSVSSGSNRTSEASS 1495

  Fly   816 SVSSSSYSENGQYR------RRQRRTS-----YNKRRSRNQKRGSTSSSCSGSEKSDRERSRSPH 869
            |.||||.|...:.|      :|.||:|     .::|.|.:....|:|||.|.|..|.|.|||||.
Human  1496 SSSSSSSSSRSRSRSLSPPHKRWRRSSCSSSGRSRRCSSSSSSSSSSSSSSSSSSSSRSRSRSPS 1560

  Fly   870 RKLRHSRSRSRSKSDTRYPNNNSSSNNNNRRGFFDRNVSQPAVEERRIVYVGRIEQETTKEILRR 934
            .:.|..|.|       ||.:..|..:...:|..    ..:.|:||||:|::|:|....|:..|::
Human  1561 PRRRSDRRR-------RYSSYRSHDHYQRQRVL----QKERAIEERRVVFIGKIPGRMTRSELKQ 1614

  Fly   935 KFLPYGSIKQITIHYKENGMKYGFVTYERAQDAFTAIDTSH--RDSQISMYDISFGGRRAFCRSS 997
            :|..:|.|::.|||::..|..||||||..|::||.||::.|  |.:....:|:.|||||.||:.|
Human  1615 RFSVFGEIEECTIHFRVQGDNYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRS 1679

  Fly   998 YADLDNAGINNYNSYVFPKEAPAPNVVEDSFEAL 1031
            |:|||    :|...:     .|||  |:..|::|
Human  1680 YSDLD----SNREDF-----DPAP--VKSKFDSL 1702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
srl	NP_649469.2	RRM_PPARGC1A_like	914..1002	CDD:409793	39/89 (44%)
PPRC1	XP_024303683.2	PHA03247	<663..1255	CDD:223021	123/677 (18%)
		RRM_PRC	1594..1684	CDD:410035	39/89 (44%)