DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment srl and PPRC1

DIOPT Version :9

Sequence 1:	NP_649469.2	Gene:	srl / 40562	FlyBaseID:	FBgn0037248	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_055877.3	Gene:	PPRC1 / 23082	HGNCID:	30025	Length:	1664	Species:	Homo sapiens

Alignment Length:	1399	Identity:	285/1399 - (20%)
Similarity:	458/1399 - (32%)	Gaps:	525/1399 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 NDELQLTDTLSGILPIAPTDESL-------------LNHNREEDLQNR---KNLLIYNDFLKQEL 79
            :|.|:.:..|..::|...::...             |:.|.||.|.:.   |...:....:.:|.
Human   378 DDSLETSSALQLLMPTLESETEAAVPKVTLCSEKEGLSLNSEEKLDSACLLKPREVVEPVVPKEP 442

  Fly    80 SNHDANELNAQVYRSIADSGGEIAYEQQRQISAIVEYDKEDIKIDGLTE--EEDIQSQSTFRTRT 142
            .|..||          |..|.:.|.:.:::.|.    ::....::|...  ....:.|||..|..
Human   443 QNPPAN----------AAPGSQRARKGRKKKSK----EQPAACVEGYARRLRSSSRGQSTVGTEV 493

  Fly   143 DSSSIGDYESHSSDYDDEFDIVNEEKSPR-------LQVVHNNIGNL-----QSSCERKG----- 190
            .|......:....:...|...:..:..||       ..:.:::..||     |||..::|
Human   494 TSQVDNLQKQPQEELQKESGPLQGKGKPRAWARAWAAALENSSPKNLERSAGQSSPAKEGPLDLY 558

  Fly   191 ----RTLSTNTI---ISEVD-----------------ALG------LSIDVNNFDLADFITKDDF 225
                .|:.||.|   :|.||                 |:|      :.:|....|||.  |..:.
Human   559 PKLADTIQTNPIPTHLSLVDSAQASPMPVDSVEADPTAVGPVLAGPVPVDPGLVDLAS--TSSEL 621

  Fly   226 AENLNACRKKESLQAQAQIKSNTLADVPILLNPPVATIVAKPGVPSSKPGDSDYDSDSIIDVETV 290
            .|.|.|                    .|:|:||.:|...|                   :|...|
Human   622 VEPLPA--------------------EPVLINPVLADSAA-------------------VDPAVV 647

  Fly   291 DVLDMNMANIWSIDKPAKMGQTPDELRYVDNVKADPSWSPRSAKKTTPTIKENKP---------E 346
            .:.|    |:..:| ....|..|.:|..||.|       |.......|.:.:::|         .
Human   648 PISD----NLPPVD-AVPSGPAPVDLALVDPV-------PNDLTPVDPVLVKSRPTDPRRGAVSS 700

  Fly   347 QLGNH--QLAVPASNKPKHKNICLVPNKKQ-CDFLKRKVGSPSLSKLTKATTKKA---------- 398
            .||..  ||.|.:.:....|.|  :|..|: .|.||.:.|       |.|||.:|
Human   701 ALGGSAPQLLVESESLDPPKTI--IPEVKEVVDSLKIESG-------TSATTHEARPRPLSLSEY 756

  Fly   399 ----------TESMS-----NKQPSVKNT-------QCTGLGLGGKNLSLLKQERDAALSVC--- 438
                      ||..|     .|.||:..|       .|..:.......:.|::..:..|.:|
Human   757 RRRRQQRQAETEERSPQPPTGKWPSLPETPTGLADIPCLVIPPAPAKKTALQRSPETPLEICLVP 821

  Fly   439 -------------AAKPIA-------------------PPTLSTTTPTLTPPAKRKLNLEEYKQR 471
                         .:||:|                   ||..|.:....|||     ::......
Human   822 VGPSPASPSPEPPVSKPVASSPTEQVPSQEMPLLARPSPPVQSVSPAVPTPP-----SMSAALPF 881

  Fly   472 RCGGVGAVYPKPTPPKQ-AKIEVAAKRIAPTPVSKPTPSPK----------------KAEIVNIV 519
            ..||:|.....|.||.| ..:.::...:.|.|.:...|.|.                ....|.:|
Human   882 PAGGLGMPPSLPPPPLQPPSLPLSMGPVLPDPFTHYAPLPSWPCYPHVSPSGYPCLPPPPTVPLV 946

  Fly   520 N--------------------------SLKC--------PRTEQ----SSLPMDPITMAKNKVLR 546
            :                          |..|        |..:.    |::|..|:..|
Human   947 SGTPGAYAVPPTCSVPWAPPPAPVSPYSSTCTYGPLGWGPGPQHAPFWSTVPPPPLPPA------ 1005

  Fly   547 MLEMKRAQQLKIIDSRVSAKVP-----RVTKLPPLKDIVKDTYCMETEDPGTEIAPLSNKLHPDY 606
              .:.||.....::||.:...|     .::..|||...:......:||....|:.|:....||.:
Human  1006 --SIGRAVPQPKMESRGTPAGPPENVLPLSMAPPLSLGLPGHGAPQTEPTKVEVKPVPASPHPKH 1068

  Fly   607 EEIIIVSA------SCNT--DITI--------------------PPNQLSKA------------- 630
            :...:|.:      :|.:  .:|:                    ||...:||
Human  1069 KVSALVQSPQMKALACVSAEGVTVEEPASERLKPETQETRPREKPPLPATKAVPTPRQSTVPKLP 1133

  Fly   631 --SPRSLLKSSVLLYNISNGQDANKNMSNSLIASIQSEVARQTSNTTLSTIQSNATKVMSSADKN 693
              .|..|.|.|.|....:.|       |..::.:..||:..:.|:  ||::.....|  |.|.|.
Human  1134 AVHPARLRKLSFLPTPRTQG-------SEDVVQAFISEIGIEASD--LSSLLEQFEK--SEAKKE 1187

  Fly   694 C-------------QHGEDMVIMHLPKDRVR---------------------------------K 712
            |             ..|.|:.....|.||::                                 |
Human  1188 CPPPAPADSLAVGNSGGVDIPQEKRPLDRLQAPELANVAGLTPPATPPHQLWKPLAAVSLLAKAK 1252

  Fly   713 TLVSIATQTDLQPE------------------------------------------FPLLTLPPK 735
            :..|.|.:..|:||                                          .|.|.:|
Human  1253 SPKSTAQEGTLKPEGVTEAKHPAAVRLQEGVHGPSRVHVGSGDHDYCVRSRTPPKKMPALVIP-- 1315

  Fly   736 RQSRERTRRNYRRRR--------TQGSGS---------------NMSTSSSDFSSDC---SSLVS 774
               ...:|.|.:|.:        :.|..:               ..|:..:|.|:.|   |||:|
Human  1316 ---EVGSRWNVKRHQDITIKPVLSLGPAAPPPPCIAASREPLDHRTSSEQADPSAPCLAPSSLLS 1377

  Fly   775 ---------HRSRSQYDSIDQLRNL--------DVAATCGGSIGNGGYSSRS-------TQRHRS 815
                     ..:|:..:...:.|::        ..:.:..|..|..|.:|||       |....|
Human  1378 PEASPCRNDMNTRTPPEPSAKQRSMRCYRKACRSASPSSQGWQGRRGRNSRSVSSGSNRTSEASS 1442

  Fly   816 SVSSSSYSENGQYR------RRQRRTS-----YNKRRSRNQKRGSTSSSCSGSEKSDRERSRSPH 869
            |.||||.|...:.|      :|.||:|     .::|.|.:....|:|||.|.|..|.|.|||||.
Human  1443 SSSSSSSSSRSRSRSLSPPHKRWRRSSCSSSGRSRRCSSSSSSSSSSSSSSSSSSSSRSRSRSPS 1507

  Fly   870 RKLRHSRSRSRSKSDTRYPNNNSSSNNNNRRGFFDRNVSQPAVEERRIVYVGRIEQETTKEILRR 934
            .:.|..|.|       ||.:..|..:...:|..    ..:.|:||||:|::|:|....|:..|::
Human  1508 PRRRSDRRR-------RYSSYRSHDHYQRQRVL----QKERAIEERRVVFIGKIPGRMTRSELKQ 1561

  Fly   935 KFLPYGSIKQITIHYKENGMKYGFVTYERAQDAFTAIDTSH--RDSQISMYDISFGGRRAFCRSS 997
            :|..:|.|::.|||::..|..||||||..|::||.||::.|  |.:....:|:.|||||.||:.|
Human  1562 RFSVFGEIEECTIHFRVQGDNYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRS 1626

  Fly   998 YADLDNAGINNYNSYVFPKEAPAPNVVEDSFEAL 1031
            |:|||    :|...:     .|||  |:..|::|
Human  1627 YSDLD----SNREDF-----DPAP--VKSKFDSL 1649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
srl	NP_649469.2	RRM	<906..>975	CDD:223796	28/68 (41%)
srl	NP_649469.2	RRM_PPARGC1A_like	914..1002	CDD:240803	39/89 (44%)
PPRC1	NP_055877.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..255
		Necessary for interaction with CREB1 and NRF1 and for transcriptional coactivation. /evidence=ECO:0000269\|PubMed:16908542	433..467		8/47 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..555		23/132 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	681..701		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..793		13/64 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..873		8/54 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1045..1068		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1093..1130		4/36 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1182..1209		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1334..1528		51/200 (26%)
		Necessary for interaction with CREB1 and NRF1. /evidence=ECO:0000269\|PubMed:16908542	1379..1450		15/70 (21%)
		RRM_PRC	1541..1631	CDD:241068	39/89 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159063
Domainoid	1	1.000	56	1.000	Domainoid score	I11016
eggNOG	1	0.900	-	-		E1_28IAX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41465
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15528
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5188
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.920