DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment srl and Pprc1

DIOPT Version :9

Sequence 1:	NP_649469.2	Gene:	srl / 40562	FlyBaseID:	FBgn0037248	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001333730.1	Gene:	Pprc1 / 226169	MGIID:	2385096	Length:	1646	Species:	Mus musculus

Alignment Length:	872	Identity:	212/872 - (24%)
Similarity:	315/872 - (36%)	Gaps:	278/872 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 PPVATIVAKPGVPSSKPGDSDYDSDSIIDVETVDVL----DMNMANIWSIDKPAKMGQTPDELRY 318
            ||...:   |.||...| .|.|.|..     ....|    .:.....||...|..:...|.. |.
Mouse   940 PPTCNV---PWVPPPAP-VSPYSSSC-----AYGSLGWGPGLQQPPFWSTVSPPPLSSVPTG-RA 994

  Fly   319 VDNVKADPSWSPRS------------------AKKTTPTIKENKPEQLGNHQLAVPASNKPKHKN 365
            |.....:||..|..                  |....|.::..|||     ...||.|.:||||.
Mouse   995 VPPTPVEPSGDPAGPPEDVLPGPVTPSLSSGPASPAAPPVEPTKPE-----AQPVPVSPQPKHKV 1054

  Fly   366 ICLV--PNKKQCDFLKRK--VGSPSLSKLTKATTKK-----------------ATESMSNKQPSV 409
            ..||  |..|....|..:  |...|:|:..|:.|::                 ..:|...|.|:|
Mouse  1055 STLVQSPQIKAPPTLSTEGVVFEESVSERLKSETQENRPKEKPISTAIKSVPVPKQSAVAKLPAV 1119

  Fly   410 KNTQ----------------------CTGLGLGGKNL-SLLKQ-ERDAALSVCAAKPIAPPTLST 450
            ...:                      .:.:|:...:| |||:| |:..|...|.....|......
Mouse  1120 HPARLRKLSFLPTPRAQGPEDVVQAFISEIGIEASDLSSLLEQFEKSEAKKECPLPASADSLAVG 1184

  Fly   451 TTPTLTPPAKRKLNLEEYKQRRCGGVGAVYPKPTPPKQAKIEVAAKRIAPTPVSKPTPSPKKAEI 515
            .:.::..|.::| .|:..:......|..:.|..|||.|....:||
Mouse  1185 NSGSIDIPQEKK-PLDRLQAPELANVAGLTPPATPPHQLWKPLAA-------------------- 1228

  Fly   516 VNIVNSLKCPRT--EQSSLPMDPITMAKNKVLRMLEMKRAQQLKIIDSRVSAKVPRVTKLPPLKD 578
            |:::...|.|::  ::.:|..:.||.||                                ||.
Mouse  1229 VSLLAKAKSPKSTAQEGTLKPEGITEAK--------------------------------PPA-- 1259

  Fly   579 IVKDTYCMETEDPGTEIAPLSNKLH-----PDYEEIIIVSASCNTDITIPPNQLSKASPRSLLKS 638
                |.|::      |.|...:.:|     .||         |....| ||    |..|..::..
Mouse  1260 ----TACLQ------EGAHSPSPVHVGSGDHDY---------CVRSRT-PP----KRMPALVISE 1300

  Fly   639 SVLLYNISNGQDANKNMSNSLIASIQSEVARQTSNTTLSTIQSNATKVMSSADKNCQHGEDMVIM 703
            ....:|:...||.......||.::........||...|    .:.|.| ..||.:..
Mouse  1301 VGSRWNVKRHQDITIKPVLSLGSAAPPLPCTATSQEPL----DHRTSV-EQADPSAP-------- 1352

  Fly   704 HLPKDRVRKTLVSIATQTDLQPE-FPLLT-----LPPKRQSRERTRRNYRRRRTQGSGSNMSTSS 762
                        ..|..|.|.|| .|..:     .||:...::::.|.||:.
Mouse  1353 ------------CFAPSTLLSPEASPCRSEMNARTPPEPSDKQQSMRCYRKA------------- 1392

  Fly   763 SDFSSDCSSLVSHRSRSQYDSIDQLRNLDVAATCGGSIGNGGYSSRS----TQRHRSSVSSSSYS 823
                  |.| ||..||                   |..|..|.||||    :.|...:.||||.|
Mouse  1393 ------CRS-VSPSSR-------------------GWQGRRGRSSRSVSSGSSRTSEASSSSSVS 1431

  Fly   824 ENGQYRRRQRRTSY---NKRRSRN-------QKRGSTSSSCSGSEKSDRERSRSPHRKLRHSRSR 878
            .:.:.|.|.|..|:   |||..|:       .:|.|:|||.|.|..|...|||||      |.|.
Mouse  1432 SSSRSRSRSRSRSFSPPNKRWRRSSCSSSGRSRRCSSSSSSSSSSSSCSSRSRSP------SVSP 1490

  Fly   879 SRSKSDTRYPNNNSSSNNNNRRGFFDRNVSQP--AVEERRIVYVGRIEQETTKEILRRKFLPYGS 941
            .| :||.|...::..:|::.:|    :.|.|.  |:||||:|::|:|....|:..|:::|..:|.
Mouse  1491 CR-RSDRRRRYSSYRANDHYQR----QRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGE 1550

  Fly   942 IKQITIHYKENGMKYGFVTYERAQDAFTAIDTSH--RDSQISMYDISFGGRRAFCRSSYADLDNA 1004
            |::.|||::..|..||||||..|::||.||::.|  |.:....:|:.|||||.||:.||:|||
Mouse  1551 IEECTIHFRVQGDNYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLD-- 1613

  Fly  1005 GINNYNSYVFPKEAPAPNVVEDSFEAL 1031
              :|...:     .|||  |:..|::|
Mouse  1614 --SNREDF-----DPAP--VKSKFDSL 1631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
srl	NP_649469.2	RRM	<906..>975	CDD:223796	30/70 (43%)
srl	NP_649469.2	RRM_PPARGC1A_like	914..1002	CDD:240803	39/89 (44%)
Pprc1	NP_001333730.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..61
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..250
		Necessary for interaction with CREB1 and NRF1 and for transcriptional coactivation. /evidence=ECO:0000250	426..461
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..617
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..762
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	774..888
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	979..1075		25/101 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1324..1509		65/255 (25%)
		Necessary for interaction with CREB1 and NRF1. /evidence=ECO:0000250	1363..1434		26/109 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849438
Domainoid	1	1.000	56	1.000	Domainoid score	I10972
eggNOG	1	0.900	-	-		E1_28IAX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto93792
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15528
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5188
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.920