DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment srl and Ppargc1b

DIOPT Version :9

Sequence 1:	NP_649469.2	Gene:	srl / 40562	FlyBaseID:	FBgn0037248	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	XP_006525761.1	Gene:	Ppargc1b / 170826	MGIID:	2444934	Length:	1046	Species:	Mus musculus

Alignment Length:	912	Identity:	170/912 - (18%)
Similarity:	321/912 - (35%)	Gaps:	264/912 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 DFAENLNACRKKESLQAQAQI------------KSNTLADVPILLNPPVATIVAKPGVPSSK-PG 275
            |.|...:|...:|.::|..|:            |....|..||   |...:.:::...|.|: |.
Mouse   304 DTASPDSAQPPEEDVRAMVQLIRYMHTYCLPQRKLPQRAPEPI---PQACSSLSRQVQPRSRHPP 365

  Fly   276 DSDYDSDSII-DVETVDVLDMNMANIWSIDKPAKMGQTPDELRYVDNVKADPSWSPRSAKKTTPT 339
            .:.:...||: ::...|:|       ..:.||.::.           :....|.:|:|..:....
Mouse   366 KAFWTEFSILRELLAQDIL-------CDVSKPYRLA-----------IPVYASLTPQSRPRPPKD 412

  Fly   340 IKENKPEQLGNHQLAVPASNKPKHKNICLVPNKKQCDFLKRKVGSPSLSKLTKATTKKATESMSN 404
            .:.:........::.:.||.|.......|.|.:.:   :||.|..|:..|..:...::..|....
Mouse   413 SQASPAHSAMAEEVRITASPKSTGPRPSLRPLRLE---VKRDVNKPTRQKREEDEEEEEEEEEEE 474

  Fly   405 KQPSVKNTQCTGLGLGGKNLSLLKQERDAALSVCAAK------PIAPPTLSTTTPTLTPPAKRKL 463
            ::...:..: .|....|:.|...|..|....|||..:      |...|.|:.|...|.......|
Mouse   475 EEKEEEEEE-WGRKRPGRGLPWTKLGRKMDSSVCPVRRSRRLNPELGPWLTFTDEPLGALPSMCL 538

  Fly   464 -----NLEEYKQRRCGGVGAVYPKPTPPKQAKIEVAAKRIAPTPVSKPTPSPKKAEIVNIVNSLK 523
                 ||||       .:|::                     |..|:....|:.::|..:.:..:
Mouse   539 DTETHNLEE-------DLGSL---------------------TDSSQGRQLPQGSQIPALESPCE 575

  Fly   524 --CPRTEQSSLPMDPITMAKNKVLRMLEMKRAQQL--KIIDSRVSAKV-------PRVTKLPPLK 577
              |..|::......|.:...::.| ||.:.::..|  |..:..::.::       |..|  ||.|
Mouse   576 SGCGDTDEDPSCPQPTSRDSSRCL-MLALSQSDSLGKKSFEESLTVELCGTAGLTPPTT--PPYK 637

  Fly   578 DIVKDTYCMETE-DPGTEIAP---------------LSNKL---HPDYEEIIIVSASCNTDITIP 623
            .:.:|.:..:|: .||.:.||               .|:||   ||:..|::   :......|.|
Mouse   638 PMEEDPFKPDTKLSPGQDTAPSLPSPEALPLTATPGASHKLPKRHPERSELL---SHLQHATTQP 699

  Fly   624 PNQLSKASPRSLLKSSVLLYNISNGQDANKNMSNSLIASIQSEVARQTSNTTLSTIQSNATKVMS 688
            .:|..:..|          ::.|.|       .:.....::.|.|.|             .||:.
Mouse   700 VSQAGQKRP----------FSCSFG-------DHDYCQVLRPEAALQ-------------RKVLR 734

  Fly   689 SADKNCQHGEDMVIMHLPKDRVRKTLVSIATQTDLQPEFPLLTLPPKRQSRER---TRRNYRRRR 750
            |.:....|.||:.....|                    .|..|..|:|::.:.   |.::..:.|
Mouse   735 SWEPIGVHLEDLAQQGAP--------------------LPTETKAPRREANQNCDPTHKDSMQLR 779

  Fly   751 --------TQGSGSNMSTSSSDFSSDCSSLVSHRSRSQYDSIDQLRNLDVAATCGGSI------- 800
                    |:..|...:....:..:.|.|       .:||::.:    |.:::.|.|.
Mouse   780 DHEIRASLTKHFGLLETALEGEDLASCKS-------PEYDTVFE----DSSSSSGESSFLLEEEE 833

  Fly   801 --GNGGYSSRSTQRHRSSVSSSSYSENGQYRRRQRRTSYNKRRSRNQKRGST-SSSCS----GSE 858
              ..||  ....:...|.||... |::..|:....:.|   |:..::.|.|: |||||    .:.
Mouse   834 EEEEGG--EEDDEGEDSGVSPPC-SDHCPYQSPPSKAS---RQLCSRSRSSSGSSSCSSWSPATR 892

  Fly   859 KSDRERSRSP----HRKLRHSRSRSRSKSDTRYPNNNSSSNNNNRRGFFDRNVSQPAVEERRIVY 919
            |:.|..||.|    ...:||:|.| |.|                            |:.|.|:||
Mouse   893 KNFRRESRGPCSDGTPSVRHARKR-REK----------------------------AIGEGRVVY 928

  Fly   920 VGRIEQETTKEILRRKFLPYGSIKQITIHYK-ENGMKYGFVTYERAQDAFTAI--DTSHRDSQIS 981
            :..:..:.:...|:::|..:|.|.:..:..: :.|.|:||:|:..::.|..::  ..:.|.....
Mouse   929 IRNLSSDMSSRELKKRFEVFGEIVECQVLTRSKRGQKHGFITFRCSEHAALSVRNGATLRKRNEP 993

  Fly   982 MYDISFGGRRAFCRSSYADLD--------NAGINNYNSYVFPKEAPAPNVVEDSFEALLLQVKAK 1038
            .:.:|:||.|.|....|.|.|        ::|.:.|.:.              .|::||.:.:..
Mouse   994 SFHLSYGGLRHFRWPRYTDYDPTSEESLPSSGKSKYEAM--------------DFDSLLKEAQQS 1044

  Fly  1039 LN 1040
            |:
Mouse  1045 LH 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
srl	NP_649469.2	RRM	<906..>975	CDD:223796	15/71 (21%)
srl	NP_649469.2	RRM_PPARGC1A_like	914..1002	CDD:240803	22/90 (24%)
Ppargc1b	XP_006525761.1	PRK10263	<194..>459	CDD:236669	32/178 (18%)
Ppargc1b	XP_006525761.1	RRM_PPARGC1B	923..1002	CDD:240802	17/78 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849440
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15528
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.990