Protein Alignment srl and PPARGC1B

DIOPT Version :10

• Sequence 1: NP_649469.2
• Gene: srl / 40562
• FlyBaseID: FBgn0037248
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: XP_011535855.1
• Gene: PPARGC1B / 133522
• HGNCID: 30022
• Length: 1064
• Species: Homo sapiens
• Alignment Length: 1162
• Identity: 196/1162 - (16%)
• Similarity: 364/1162 - (31%)
• Gaps: 361/1162 - (31%)

  Fly    70 IYNDFLKQELSNHDANELNAQVYRSIADSGGEIAYEQQRQISAIVEYDKEDIKIDGLTEEEDIQS 134
            :|.||.:.:||..||::.::      |...||:.:..:...:...:|..:|.::..:..|.:...
Human    35 LYADFPELDLSQLDASDFDS------ATCFGELQWCPENSETEPNQYSPDDSELFQIDSENEALL 93

  Fly   135 QSTFRTRTD--SSSIGDYESHSSDYDDEFDIVNEEKSPRLQVVHNNIGNLQSSCERKGRTLSTNT 197
            ....:|..|  ...:|.....:.|..|.....:...:|             ||..........:.
Human    94 AELTKTLDDIPEDDVGLAAFPALDGGDALSCTSASPAP-------------SSAPPSPAPEKPSA 145

  Fly   198 IISEVDALGLSIDVNNFDLA-DFITKDDFAENLNACRKKESLQAQAQ---IKSNTLAD--VPIL- 255
            ...|||.|.|   :....|| .:.|.....:......::..|::::|   :|:::..|  .|::
Human   146 PAPEVDELSL---LQKLLLATSYPTSSSDTQKEGTAWRQAGLRSKSQRPCVKADSTQDKKAPMMQ 207

  Fly   256 ------------------------LNPPVATIVAKPGVPSSKPGDSDYDSDSIIDVETVDVLDMN 296
                                    |.||.......|.....:||:
Human   208 SQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSPRLPAKEDKEPGE-------------------- 252

  Fly   297 MANIWSIDKPAKMGQTPDELRYVDNVKADPSWSPRSAKKTTPTIKENKPEQLGNHQLAVPASNKP 361
                   |.|:                  |..:|.|.:.:.         .||......|.|.:.
Human   253 -------DCPS------------------PQPAPASPRDSL---------ALGRADPGAPVSQED 283

  Fly   362 KHKNICLVPNKKQCDFLKRKVGSPSLSKLTKATTKKATESMSNKQPSVKNTQCTGLGLGGKNLSL 426
            ....:.|:.........:||:...:...|.||.: ..::.:.::..|..:::.:     ....|:
Human   284 MQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACS-NPSQQVRSRPWSRHHSKAS-----WAEFSI 342

  Fly   427 LKQ--ERDAALSVCAAKPIAPPTLSTTTPTLTPPAKRKLNLEEYKQRRCGGVGAVYPKPTPPKQA 489
            |::  .:|....|.....:|.|..::.||.                          .:|.|||.:
Human   343 LRELLAQDVLCDVSKPYRLATPVYASLTPR--------------------------SRPRPPKDS 381

  Fly   490 KI------EVAAKRIAPTPVSK-PTPS--PKKAEIVNIVNSLKCPRTEQS--------------- 530
            :.      .|...|||.:|.|. |.||  |.:.|:...|.  :..|.:|.
Human   382 QASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVR--RPARLQQQEEEDEEEEEEEEEEE 444

  Fly   531 --------------SLPMDPITMAKNKVLRMLE-----MKRAQQLK-------------IIDSRV 563
                          .||.       .|:.|.||     ::|:::|.             ::.|..
Human   445 KEEEEEWGRKRPGRGLPW-------TKLGRKLESSVCPVRRSRRLNPELGPWLTFADEPLVPSEP 502

  Fly   564 SAKVPRVTKLPPLKDIVKDTYCMETEDPGTEIAPLSNKLHP-----------DYEEIIIVSASCN 617
            ...:|.:...|...|:.::......||.|.:...|.....|           |.:|    ..||.
Human   503 QGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGPQIPALESPCESGCGDMDE----DPSCP 563

  Fly   618 TDITIPPNQLSKASPRSLLKSSVLLYNISNGQDANKNMSNSLIA--------------------- 661
               .:||    :.|||.|:    |..:.|:.....|:...:|..
Human   564 ---QLPP----RDSPRCLM----LALSQSDPTFGKKSFEQTLTVELCGTAGLTPPTTPPYKPTEE 617

  Fly   662 ---------SIQSEVARQTSNTTLSTIQSNATKVMSSADKNCQHGEDMVIMHLPKDRVRKTLVSI 717
                     |:..|:|....:....::::..........|:.:..|  ::.||     |......
Human   618 DPFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPERSE--LLSHL-----RHATAQP 675

  Fly   718 ATQTDLQPEFP--------LLTLPPKRQSRERTRRNYR-----------------RRRTQGSGSN 757
            |:|...:..|.        ...|.|:...:.:..|::.                 ..:..|...:
Human   676 ASQAGQKRPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREED 740

  Fly   758 MSTSSSDFSSDCSSLVSHRSRS----QYDSIDQLRNLDVAATCGGSIGNGGYSSRSTQRHRSSVS 818
            .|..:.....|.:.|..|..|:    .:..::.....:..|:|.....:..:...|:....||..
Human   741 RSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFL 805

  Fly   819 SSSYSENGQYRRRQRRTSYNKRRSRNQKRGSTSSSCSGSEKSDRERSRSPHRKLRH---SRSRSR 880
            .....|.|:          .:.....::....|.:|     ||....:||..|...   |||||.
Human   806 PEEEEEEGE----------EEEEDDEEEDSGVSPTC-----SDHCPYQSPPSKANRQLCSRSRSS 855

  Fly   881 SKSDTRYPNNNSSSNN---NNRRGFFDRNVS--------QPAVEERRIVYVGRIEQETTKEILRR 934
            |.|...:..:.::..|   .:|....||..|        :.|:.|.|:||:..:..:.:...|:|
Human   856 SGSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGEGRVVYIQNLSSDMSSRELKR 920

  Fly   935 KFLPYGSIKQITIHYK-ENGMKYGFVTYERAQDAFTAI--DTSHRDSQISMYDISFGGRRAFCRS 996
            :|..:|.|::..:..: ..|.||||:||..::.|..::  ..:.|......:.:|:||.|.||..
Human   921 RFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSYGGLRHFCWP 985

  Fly   997 SYADLDNAG--------------------INNYNSYVFPKEAPAPNVVEDSFEALLL 1033
            .|.|.|..|                    .:|.|:.||         :.|::.:|||
Human   986 RYTDYDWEGWEVEQKEPAEGTQKHGSRVRTSNINARVF---------LSDTYFSLLL 1033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
srl	NP_649469.2	RRM_PPARGC1A_like	914..1002	CDD:409793	26/90 (29%)
PPARGC1B	XP_011535855.1	RRM_PPARGC1B	895..991	CDD:409792	27/95 (28%)