DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment srl and PPARGC1A

DIOPT Version :9

Sequence 1:	NP_649469.2	Gene:	srl / 40562	FlyBaseID:	FBgn0037248	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001317680.1	Gene:	PPARGC1A / 10891	HGNCID:	9237	Length:	803	Species:	Homo sapiens

Alignment Length:	957	Identity:	217/957 - (22%)
Similarity:	344/957 - (35%)	Gaps:	240/957 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 EEKSPRLQVVHNNIGNLQSSCERKGRTLSTNTIISEVDALGLS-IDVNNFDLADFITKDDFAENL 229
            :|.||||:.....:...::..:..........:..::..|.|| :|||:.|      .|.|...|
Human     2 DETSPRLEEDWKKVLQREAGWQCAALVGEDQPLCPDLPELDLSELDVNDLD------TDSFLGGL 60

  Fly   230 NACRKKESLQAQAQIKSNTLADVPILLNPPVATIVAKPGVPSSKPGDSDYDSDSI-IDVETVDVL 293
            ..|      ..|::|.||...:.|       :.|..|.        |.:.:::.: :..||:|.|
Human    61 KWC------SDQSEIISNQYNNEP-------SNIFEKI--------DEENEANLLAVLTETLDSL 104

  Fly   294 DMNMANIWSIDKPAKMGQTPDELRYVDNVKADPSWSPRSAKKTTPTIKENKPEQLGNHQLAVPAS 358
            .::...:.|.|....           .:|..|...||.|....||..:|.:...|....|..||:
Human   105 PVDEDGLPSFDALTD-----------GDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPAN 158

  Fly   359 NKPKHKNICLVPNKKQCDFLKRKVGSPSLSKLTKATTKKATESMSNKQPSVKNTQCTGLGLGGKN 423
            .:..:.....:..:...:...|...:|::.|...:.:.||......::|  :...|:
Human   159 TQLSYNECSGLSTQNHANHNHRIRTNPAIVKTENSWSNKAKSICQQQKP--QRRPCS-------- 213

  Fly   424 LSLLK--------------QERDAALSVCAAK------------PIAPPTLSTTTPTLTP----- 457
             .|||              :.|:::...|.:|            ...|.|||.   .|||
Human   214 -ELLKYLTTNDDPPHTKPTENRNSSRDKCTSKKKSHTQSQSQHLQAKPTTLSL---PLTPESPND 274

  Fly   458 ----PAKRKLNLEEYKQRRCGGVGAVYPKPTPPKQA----------KIEVAAKRIAPTPVSKPTP 508
                |.:.| .:|........|...:.|..|||.:|          |::.:.|.:.|.|..||..
Human   275 PKGSPFENK-TIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRY 338

  Fly   509 SPKKAEIVNIVNSLKCPRTEQSSLPMDPITMAKNKVLRMLEMKRAQQLKIIDSRVSAKVPRVTKL 573
            |.......|  ||.| ...|||.|...   ::|:.||                 ......|.||.
Human   339 SESSGTQGN--NSTK-KGPEQSELYAQ---LSKSSVL-----------------TGGHEERKTKR 380

  Fly   574 PPLKDIVKDTYCMETEDPGTEI-----------APLSNK-LHPDYEEIIIVSA---SCNTDITIP 623
            |.|:......|| ::.:..|||           ..|.|| :..|::..|..|.   .|....|:.
Human   381 PSLRLFGDHDYC-QSINSKTEILINISQELQDSRQLENKDVSSDWQGQICSSTDSDQCYLRETLE 444

  Fly   624 PN-QLSKASPRSLLKSSVLLYNISNGQDANKNMSNSLIASIQSEVARQTSNTTLSTIQSNATKVM 687
            .: |:|..|.|..|:..                      .|::|:.:...:.:.:.....|.|..
Human   445 ASKQVSPCSTRKQLQDQ----------------------EIRAELNKHFGHPSQAVFDDEADKTG 487

  Fly   688 SSADKNCQHGEDMVIMHLPKDRVRKTLVSIATQTDLQPEFPLLTLPPKRQSRERTRRNYRRRRTQ 752
            ...|.:..:.:   ...||. .:...|.......|.:.|...|:.|                 ..
Human   488 ELRDSDFSNEQ---FSKLPM-FINSGLAMDGLFDDSEDESDKLSYP-----------------WD 531

  Fly   753 GSGS----NMSTSSSDFSSDCSSLVS----------HRSRSQYDSIDQLRNLDVAATCGGSIGNG 803
            |:.|    |:|.|.|.|:|.|...||          .|.||:..|..:.|          |....
Human   532 GTQSYSLFNVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHR----------SCSRS 586

  Fly   804 GYSSRSTQR---HRSSVSSSSYSENGQYRRRQRRTSYNKRRSRNQKRGSTSSSCSGSEKSDRER- 864
            .| |||..|   .|||..|..|.|:..||.|..|.|....|||::...|........|:...||
Human   587 PY-SRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEEYQHERL 650

  Fly   865 SRSPHRKLRHSRSRSRSKSDTRYPNNNSSSNNNNRRGFFDRNVSQPAVEERRIVYVGRIEQETTK 929
            .|..:|:....|...|:|...|.                    .|.|:||||::|||:|..:||:
Human   651 KREEYRREYEKRESERAKQRERQ--------------------RQKAIEERRVIYVGKIRPDTTR 695

  Fly   930 EILRRKFLPYGSIKQITIHYKENGMKYGFVTYERAQDAFTAIDTSH--RDSQISMYDISFGGRRA 992
            ..||.:|..:|.|::.|::.:::|..|||:||....|||.|::..:  |.|..:.:::.|.||:.
Human   696 TELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQ 760

  Fly   993 FCRSSYADLDNAGINNYNSYVFPKEAPAPNVVEDSFEALLLQVKAKL 1039
            |.:|:|||||:      ||..|...:.........|::||.:.:..|
Human   761 FFKSNYADLDS------NSDDFDPASTKSKYDSLDFDSLLKEAQRSL 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
srl	NP_649469.2	RRM	<906..>975	CDD:223796	28/68 (41%)
srl	NP_649469.2	RRM_PPARGC1A_like	914..1002	CDD:240803	35/89 (39%)
PPARGC1A	NP_001317680.1	RFX5_DNA_bdg	257..>384	CDD:317070	38/153 (25%)
		DDRGK	643..>680	CDD:313051	11/56 (20%)
		RRM_PPARGC1A	680..770	CDD:241067	35/89 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159061
Domainoid	1	1.000	56	1.000	Domainoid score	I11016
eggNOG	1	0.900	-	-		E1_28IAX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8229
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006880
OrthoInspector	1	1.000	-	-		otm41465
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15528
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5188
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.870