DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32944 and Rps6kb1

DIOPT Version :9

Sequence 1:	NP_788574.3	Gene:	CG32944 / 40560	FlyBaseID:	FBgn0052944	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_114191.1	Gene:	Rps6kb1 / 83840	RGDID:	620683	Length:	525	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	124/453 - (27%)
Similarity:	219/453 - (48%)	Gaps:	62/453 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 FQILRAIGKGSFGKVCIVQK---RDTGILYAMKYVSRSACEMRGALGGVIKEVE--LLSSLEHPF 210
            |::||.:|||.:|||..|:|   .:||.::||| |.:.|..:|.|......:.|  :|..::|||
  Rat    91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMK-VLKKAMIVRNAKDTAHTKAERNILEEVKHPF 154

  Fly   211 LVNLWFSFQDEEDLFMVCDLLTGGDLRYHLQNRVEFSEQSVALLVCELGSALEYLQANRVVHRDI 275
            :|:|.::||....|:::.:.|:||:|...|:....|.|.:....:.|:..||.:|....:::||:
  Rat   155 IVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDL 219

  Fly   276 KPDNILLDDAGHAHLTDFNIATR-LQKNALACSMSGTKPYMAPEVFLCALDEVAGYSYPVDWWSL 339
            ||:||:|:..||..||||.:... :....:..:..||..|||||:.:     .:|::..||||||
  Rat   220 KPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM-----RSGHNRAVDWWSL 279

  Fly   340 GVVAYEMRGNIRPFVVHSNTPLAEIKNILNTPVHYPRYWSSNFVDLLQRLLSTYPGARIST---- 400
            |.:.|:|.....||...:..  ..|..||...::.|.|.:....|||::||.....:|:..
  Rat   280 GALMYDMLTGAPPFTGENRK--KTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGD 342

  Fly   401 RQELHQTPMLRNIDFQRVLEKKIKPIYKPPEDHLNCDPCLELEEMIVESRPLHKKKKRLAKQRSA 465
            ..|:...|..|:|:::.:|.:|::..:|         |.|:.||.:.:.      ..:..:|...
  Rat   343 AGEVQAHPFFRHINWEELLARKVERPFK---------PLLQSEEDVSQF------DSKFTRQTPV 392

  Fly   466 QRDSDPETALVKEFI--VYNRYKELKRKAMEQKENDWQRELELAMANSIVNS----LAPIQEKPA 524
              || |:.:.:.|..  |:..:..:....:|..:..:..|.::......:.|    ::|::..|
  Rat   393 --DS-PDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSP- 453

  Fly   525 ACVVHDGDC----ATASSAVAQ------LKGESIEFIDRTPSPQIKESAGSRLDMPQS-PFQK 576
                  ||.    |:||:|..|      ::...||.:|.|.|.:  .||...:..|.| |::|
  Rat   454 ------GDFWGRGASASTANPQTPVEYPMETSGIEQMDVTTSGE--ASAPLPIRQPNSGPYKK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32944	NP_788574.3	STKc_Yank1	150..410	CDD:270730	86/268 (32%)
CG32944	NP_788574.3	S_TKc	151..405	CDD:214567	85/263 (32%)
Rps6kb1	NP_114191.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..54
		TOS motif	28..32
		S_TKc	91..352	CDD:214567	86/268 (32%)
		STKc_p70S6K	94..416	CDD:270736	100/347 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..399		4/27 (15%)
		Autoinhibitory domain	424..525		22/94 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..509		8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900