DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32944 and mast1b

DIOPT Version :9

Sequence 1:	NP_788574.3	Gene:	CG32944 / 40560	FlyBaseID:	FBgn0052944	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_009297388.1	Gene:	mast1b / 796144	ZFINID:	ZDB-GENE-131025-2	Length:	1634	Species:	Danio rerio

Alignment Length:	523	Identity:	136/523 - (26%)
Similarity:	222/523 - (42%)	Gaps:	108/523 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 LLQVDVLPPFFLCPR---QRLQLIQIIPKFH--------PEDHSLAMGHMLCVKCQSLIPINFDH 150
            |::.|:  |.::..:   .|..|.:::.:.|        ||....|.|.|..:|     |.....
Zfish   306 LMKTDI--PRYIISQLGLTRDPLEEMVSREHYDSEGPVTPETDDSAEGKMKPMK-----PPGEAD 363

  Fly   151 FQILRAIGKGSFGKVCIVQKRDTGILYAMKYVSRSACEMRGALGGVIKEVELLSSLEHPFLVNLW 215
            ||.::.|..|::|:|.:|:..:|...:|||.:::....:|..:.....|.::|:..|:||:|:::
Zfish   364 FQTIKLISNGAYGEVYLVRHLETRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMF 428

  Fly   216 FSFQDEEDLFMVCDLLTGGDLRYHLQNRVEFSEQSVALLVCELGSALEYLQANRVVHRDIKPDNI 280
            .||:....|.||.:.:.|||....|:|......:...:...|...||||:....:||||:||||:
Zfish   429 CSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYIHNYGIVHRDLKPDNL 493

  Fly   281 LLDDAGHAHLTDFNIAT-------------RLQKNA---LACSMSGTKPYMAPEVFLCALDEVAG 329
            |:...||..||||.::.             .::|:.   |...:.||..|:||||.|     ..|
Zfish   494 LITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDTREFLDKQVCGTPEYIAPEVIL-----RQG 553

  Fly   330 YSYPVDWWSLGVVAYEMRGNIRPFVVHSNTPLAEIKNILNTPVHYPRYWSSNFVD---LLQRLLS 391
            |..|||||::|::.||......||  ..:||......:::..:.:|....:...|   |:..||.
Zfish   554 YGKPVDWWAMGIILYEFLVGCVPF--FGDTPEELFGQVISDDIVWPEDDDALPPDAQHLISSLLQ 616

  Fly   392 TYPGARIST--RQELHQTPMLRNIDFQRVLEKKIKPIYKPPEDHLNCDPCLELEEMIVESRPLHK 454
            |.|..|:.|  ..|:.|.|...::|:..:|.:|.:.|           |.||.||   ::.....
Zfish   617 TSPLLRLGTGGAFEVKQHPFFGDLDWGSLLRQKAEFI-----------PNLESEE---DTSYFDT 667

  Fly   455 KKKRLAKQRSAQRD--SDPETALVKEFI--------VYNRYKELKRKAMEQKENDWQRELELAMA 509
            :.:|.....|...|  :|.|...:..|.        ||:..:.|.:  :|.|....:||
Zfish   668 RSERYHHVHSYDEDDTNDDEPVEIHRFSSCSPRFSKVYSSMEHLSQ--LEHKPVVTRRE------ 724

  Fly   510 NSIVNSLAPIQEKPAACVVHDGDCATASSAVAQLKGESIEFID---RTPSPQIKESAGSRLDMPQ 571
                       .||     |..|.|...|.      .|:...|   ||.||::|     ||...:
Zfish   725 -----------PKP-----HREDRAKRESM------GSLTLRDKTWRTGSPEMK-----RLSCSE 762

  Fly   572 SPF 574
            |.|
Zfish   763 SSF 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32944	NP_788574.3	STKc_Yank1	150..410	CDD:270730	84/280 (30%)
CG32944	NP_788574.3	S_TKc	151..405	CDD:214567	82/274 (30%)
mast1b	XP_009297388.1	DUF1908	55..328	CDD:286070	5/23 (22%)
		STKc_MAST	363..642	CDD:270760	84/285 (29%)
		S_TKc	364..637	CDD:214567	84/279 (30%)
		PDZ_signaling	949..1031	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589142
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930