DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32944 and RPS6KB2

DIOPT Version :9

Sequence 1:	NP_788574.3	Gene:	CG32944 / 40560	FlyBaseID:	FBgn0052944	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_003943.2	Gene:	RPS6KB2 / 6199	HGNCID:	10437	Length:	482	Species:	Homo sapiens

Alignment Length:	388	Identity:	111/388 - (28%)
Similarity:	189/388 - (48%)	Gaps:	49/388 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 LPPFFLCPRQRLQLIQIIPKFHPEDHSLAMGHMLCVKCQSLIPINFDH-----FQILRAIGKGSF 162
            |.|...||...|:...:.|..|.|:..|.         ::.:.:..:.     |::||.:|||.:
Human    23 LSPADACPLAELRAAGLEPVGHYEEVELT---------ETSVNVGPERIGPHCFELLRVLGKGGY 78

  Fly   163 GKVCIVQK---RDTGILYAMKYVSRSACEMRGALGGVIKEVE--LLSSLEHPFLVNLWFSFQDEE 222
            |||..|:|   .:.|.:|||| |.|.|..:|.|........|  :|.|::|||:|.|.::||...
Human    79 GKVFQVRKVQGTNLGKIYAMK-VLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGG 142

  Fly   223 DLFMVCDLLTGGDLRYHLQNRVEFSEQSVALLVCELGSALEYLQANRVVHRDIKPDNILLDDAGH 287
            .|:::.:.|:||:|..||:....|.|.:....:.|:..||.:|.:..:::||:||:||:|...||
Human   143 KLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGH 207

  Fly   288 AHLTDFNIATR-LQKNALACSMSGTKPYMAPEVFLCALDEVAGYSYPVDWWSLGVVAYEMRGNIR 351
            ..||||.:... :.:.|:..:..||..|||||:.:     .:|::..|||||||.:.|:|.....
Human   208 IKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILV-----RSGHNRAVDWWSLGALMYDMLTGSP 267

  Fly   352 PFVVHSNTPLAEIKNILNTPVHYPRYWSSNFVDLLQRLLSTYPGARI----STRQELHQTPMLRN 412
            ||...:.....:  .|:...:..|.|.:.:..||:::.|...|..||    ....::.:.|..|:
Human   268 PFTAENRKKTMD--KIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRH 330

  Fly   413 IDFQRVLEKKIKPIYKPPEDHLNCDPCLELEEMIVESRPLHKKKKRLAKQRSAQRDSDPETAL 475
            :::..:|..::.|.::         |||:.||.:.:.      ..|..:|...  ||..:|||
Human   331 MNWDDLLAWRVDPPFR---------PCLQSEEDVSQF------DTRFTRQTPV--DSPDDTAL 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32944	NP_788574.3	STKc_Yank1	150..410	CDD:270730	87/274 (32%)
CG32944	NP_788574.3	S_TKc	151..405	CDD:214567	86/263 (33%)
RPS6KB2	NP_003943.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		1/2 (50%)
		S_TKc	67..328	CDD:214567	87/268 (32%)
		STKc_p70S6K	70..392	CDD:270736	101/332 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..482
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:12529391	471..477
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900