DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32944 and RPS6KB1

DIOPT Version :9

Sequence 1:	NP_788574.3	Gene:	CG32944 / 40560	FlyBaseID:	FBgn0052944	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_003152.1	Gene:	RPS6KB1 / 6198	HGNCID:	10436	Length:	525	Species:	Homo sapiens

Alignment Length:	453	Identity:	125/453 - (27%)
Similarity:	220/453 - (48%)	Gaps:	62/453 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 FQILRAIGKGSFGKVCIVQK---RDTGILYAMKYVSRSACEMRGALGGVIKEVE--LLSSLEHPF 210
            |::||.:|||.:|||..|:|   .:||.::||| |.:.|..:|.|......:.|  :|..::|||
Human    91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMK-VLKKAMIVRNAKDTAHTKAERNILEEVKHPF 154

  Fly   211 LVNLWFSFQDEEDLFMVCDLLTGGDLRYHLQNRVEFSEQSVALLVCELGSALEYLQANRVVHRDI 275
            :|:|.::||....|:::.:.|:||:|...|:....|.|.:....:.|:..||.:|....:::||:
Human   155 IVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDL 219

  Fly   276 KPDNILLDDAGHAHLTDFNIATR-LQKNALACSMSGTKPYMAPEVFLCALDEVAGYSYPVDWWSL 339
            ||:||:|:..||..||||.:... :....:..:..||..|||||:.:     .:|::..||||||
Human   220 KPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM-----RSGHNRAVDWWSL 279

  Fly   340 GVVAYEMRGNIRPFVVHSNTPLAEIKNILNTPVHYPRYWSSNFVDLLQRLLSTYPGARIST---- 400
            |.:.|:|.....||...:..  ..|..||...::.|.|.:....|||::||.....:|:..
Human   280 GALMYDMLTGAPPFTGENRK--KTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGD 342

  Fly   401 RQELHQTPMLRNIDFQRVLEKKIKPIYKPPEDHLNCDPCLELEEMIVESRPLHKKKKRLAKQRSA 465
            ..|:...|..|:|:::.:|.:|::|.:|         |.|:.||.:.:.      ..:..:|...
Human   343 AGEVQAHPFFRHINWEELLARKVEPPFK---------PLLQSEEDVSQF------DSKFTRQTPV 392

  Fly   466 QRDSDPETALVKEFI--VYNRYKELKRKAMEQKENDWQRELELAMANSIVNS----LAPIQEKPA 524
              || |:.:.:.|..  |:..:..:....:|..:..:..|.::......:.|    ::|::..|
Human   393 --DS-PDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSP- 453

  Fly   525 ACVVHDGDC----ATASSAVAQ------LKGESIEFIDRTPSPQIKESAGSRLDMPQS-PFQK 576
                  ||.    |:||:|..|      ::...||.:|.|.|.:  .||...:..|.| |::|
Human   454 ------GDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGE--ASAPLPIRQPNSGPYKK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32944	NP_788574.3	STKc_Yank1	150..410	CDD:270730	86/268 (32%)
CG32944	NP_788574.3	S_TKc	151..405	CDD:214567	85/263 (32%)
RPS6KB1	NP_003152.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54
		TOS motif	28..32
		STKc_p70S6K	94..416	CDD:270736	101/347 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..399		4/27 (15%)
		Autoinhibitory domain	424..525		22/94 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810