Protein Alignment CG32944 and RPS6KA3

DIOPT Version :10

• Sequence 1: NP_788574.3
• Gene: CG32944 / 40560
• FlyBaseID: FBgn0052944
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: XP_011543857.1
• Gene: RPS6KA3 / 6197
• HGNCID: 10432
• Length: 746
• Species: Homo sapiens
• Alignment Length: 442
• Identity: 123/442 - (27%)
• Similarity: 196/442 - (44%)
• Gaps: 82/442 - (18%)

  Fly   128 HSLAMGHMLCVKCQSLIPINFDHFQILRAIGKGSFGKVCIVQK---RDTGILYAMKYVSRSACEM 189
            |.:..||......|         |::|:.:|:||||||.:|:|   .|...|||||.:.::..::
Human    54 HHVKEGHEKADPSQ---------FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKV 109

  Fly   190 RGALGGVIKEVELLSSLEHPFLVNLWFSFQDEEDLFMVCDLLTGGDLRYHLQNRVEFSEQSVALL 254
            |..:...: |.::|..:.|||:|.|.::||.|..|:::.|.|.||||...|...|.|:|:.|...
Human   110 RDRVRTKM-ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFY 173

  Fly   255 VCELGSALEYLQANRVVHRDIKPDNILLDDAGHAHLTDFNIATR-LQKNALACSMSGTKPYMAPE 318
            :.||..||::|.:..:::||:||:|||||:.||..||||.::.. :.....|.|..||..|||||
Human   174 LAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPE 238

  Fly   319 VFLCALDEVAGYSYPVDWWSLGVVAYEMRGNIRPFVVHSNTPLAEIKNILNTPVHYPRYWSSNFV 383
            |.     ...|::...||||.||:.:||.....||  ........:..||...:..|::.|....
Human   239 VV-----NRRGHTQSADWWSFGVLMFEMLTGTLPF--QGKDRKETMTMILKAKLGMPQFLSPEAQ 296

  Fly   384 DLLQRLLSTYPGARISTR----------QELHQTPMLRNIDFQRVLEKKIKPIYKP----PEDHL 434
            .||:.|....|..|:...          :|:.:......||:.::..::|.|.:||    |||..
Human   297 SLLRMLFKRNPANRLVNPFLIGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTF 361

  Fly   435 NCDP-------------------------------CLELEEMIVESRPLHKKKKRLAKQRSAQRD 468
            ..||                               ..:.|...:::..:|...::| .:.|.|..
Human   362 YFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQL-HRNSIQFT 425

  Fly   469 SDPETALVKEFIVYNRYKELKR------------KAMEQKENDWQRELELAM 508
            ...|   |||.|....|...||            |.:::.:.|...|:|:.:
Human   426 DGYE---VKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILL 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32944	NP_788574.3	STKc_Yank1	150..410	CDD:270730	91/273 (33%)
RPS6KA3	XP_011543857.1	STKc_RSK_N	72..394	CDD:270734	100/329 (30%)
		STKc_RSK2_C	408..737	CDD:271078	16/71 (23%)