DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32944 and Mast2

DIOPT Version :9

Sequence 1:	NP_788574.3	Gene:	CG32944 / 40560	FlyBaseID:	FBgn0052944	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_017448927.2	Gene:	Mast2 / 313819	RGDID:	1304573	Length:	1861	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	136/581 - (23%)
Similarity:	223/581 - (38%)	Gaps:	174/581 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 DHFQILRAIGKGSFGKVCIVQKRDTGILYAMKYVSRSACEMRGALGGVIKEVELLSSLEHPFLVN 213
            :.|:.::.|..|::|.|.:|:.:.|...:|||.:::....:|..:.....|.::|:..|:||:|:
  Rat   583 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVS 647

  Fly   214 LWFSFQDEEDLFMVCDLLTGGDLRYHLQNRVEFSEQSVALLVCELGSALEYLQANRVVHRDIKPD 278
            ::.||:.:..|.||.:.:.|||....|:|........|.|...|...|||||....:||||:|||
  Rat   648 MFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPD 712

  Fly   279 NILLDDAGHAHLTDFNIAT-------------RLQKNA---LACSMSGTKPYMAPEVFLCALDEV 327
            |:|:...||..||||.::.             .::|:|   |...:.||..|:||||.|     .
  Rat   713 NLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVIL-----R 772

  Fly   328 AGYSYPVDWWSLGVVAYEMRGNIRPFVVHSNTPLAEIKNILNTPVHYPR---YWSSNFVDLLQRL 389
            .||..|||||::|::.||......||  ..:||......:::..:.:|.   ....:..||..:|
  Rat   773 QGYGKPVDWWAMGIILYEFLVGCVPF--FGDTPEELFGQVISDEIVWPEGDDALPPDAQDLTSKL 835

  Fly   390 LSTYPGARISTRQ--ELHQTPMLRNIDFQRVLEKKIK----------------------PIYKPP 430
            |...|..|:.|..  |:.|.|....:|:..:|.:|.:                      .:....
  Rat   836 LHQNPLERLGTSSAYEVKQHPFFMGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHVDSED 900

  Fly   431 EDHLNCDPCLELEEM------------------IVE--------SRPLHKKK------------- 456
            |:.::.|.|||:.:.                  ::|        .|.|.::|
  Rat   901 EEEVSEDGCLEIRQFSSCSPRFSKVYSSMERLSLLEGHRTPPPTKRSLSEEKEDHSDGLAGLKGR 965

  Fly   457 -------------KRLAKQRSAQRDSDPETALVKEFIVYNR--YKELKRKAME--------QKEN 498
                         |||:...|:..:||....:.    |.:|  ..::.|.|.|        |:|.
  Rat   966 DRSWVIGSPEILRKRLSVSESSHTESDSSPPMT----VRHRSGLPDVPRCAEETSSTPRKQQQEG 1026

  Fly   499 DWQRELELAMANSIVNSLAPIQEKP----------------AACVVHD----GDCATASSAVAQ- 542
            .|     :....|...|..|:.|:|                .:|...:    |....|..|.|:
  Rat  1027 IW-----VLTPPSGEGSSRPVPERPLERQLKLDEEPPGQSSRSCPAMETRGRGTPQLAEEATAKA 1086

  Fly   543 -------------LKGESIEFIDRTPSP---QIKESAGSRLDM--------------PQSP 573
                         |.|:|||  .||..|   .||.::.:.|.:              |.||
  Rat  1087 ISDLAVRRARHRLLSGDSIE--KRTTRPVNKVIKSASATALSLLIPSEHHACSPLASPMSP 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32944	NP_788574.3	STKc_Yank1	150..410	CDD:270730	86/280 (31%)
CG32944	NP_788574.3	S_TKc	151..405	CDD:214567	84/274 (31%)
Mast2	XP_017448927.2	DUF1908	267..548	CDD:401031
		STKc_MAST	584..863	CDD:270760	86/285 (30%)
		PDZ_signaling	1174..1255	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347611
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930