DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32944 and C8orf44-SGK3

DIOPT Version :9

Sequence 1:	NP_788574.3	Gene:	CG32944 / 40560	FlyBaseID:	FBgn0052944	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001191102.1	Gene:	C8orf44-SGK3 / 100533105	HGNCID:	48354	Length:	496	Species:	Homo sapiens

Alignment Length:	361	Identity:	116/361 - (32%)
Similarity:	169/361 - (46%)	Gaps:	53/361 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 KFHPEDHSLAMGHMLCVKCQSLIPINFDH-----FQILRAIGKGSFGKVCIVQKRDTGILYAMKY 181
            |.|....::.:|           |....|     |..|:.|||||||||.:.:::..|..||:|.
Human   139 KLHSTSQNINLG-----------PSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKV 192

  Fly   182 VSRSACEMRGALGGVIKEVE-LLSSLEHPFLVNLWFSFQDEEDLFMVCDLLTGGDLRYHLQNRVE 245
            :.:.....|.....::.|.. ||.:::|||||.|.:|||..|.|:.|.|.:.||:|.:|||....
Human   193 LQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERS 257

  Fly   246 FSEQSVALLVCELGSALEYLQANRVVHRDIKPDNILLDDAGHAHLTDFNIATRLQKNALACS--- 307
            |.|........|:.|||.||.:.::|:||:||:|||||..||..||||.:.    |..:|.|
Human   258 FPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLC----KEGIAISDTT 318

  Fly   308 --MSGTKPYMAPEVFLCALDEVAGYSYPVDWWSLGVVAYEMRGNIRPFVVHSNTPLAEI-KNILN 369
              ..||..|:||||.     ....|...||||.||.|.|||...:.||....   :||: .|||:
Human   319 TTFCGTPEYLAPEVI-----RKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRD---VAEMYDNILH 375

  Fly   370 TPVHYPRYWSSNFVDLLQRLLSTYPGARISTRQ---ELHQTPMLRNIDFQRVLEKKIKPIYKP-- 429
            .|:......|.....:|:.||......|:..::   |:...|...::.:..:::|||.|.:.|
Human   376 KPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNV 440

  Fly   430 --PEDHLNCDP-----------CLELEEMIVESRPL 452
              |:|..|.|.           |:..:..||.:..|
Human   441 AGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVL 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32944	NP_788574.3	STKc_Yank1	150..410	CDD:270730	99/274 (36%)
CG32944	NP_788574.3	S_TKc	151..405	CDD:214567	97/263 (37%)
C8orf44-SGK3	NP_001191102.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PX_CISK	12..120	CDD:132780
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..156		4/27 (15%)
		STKc_SGK3	165..490	CDD:270755	110/324 (34%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		1/9 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900