DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lost and COG0212

DIOPT Version :9

Sequence 1:	NP_649466.1	Gene:	lost / 40559	FlyBaseID:	FBgn0263594	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_565139.1	Gene:	COG0212 / 844007	AraportID:	AT1G76730	Length:	354	Species:	Arabidopsis thaliana

Alignment Length:	275	Identity:	96/275 - (34%)
Similarity:	150/275 - (54%)	Gaps:	9/275 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AVAAENGGNTAQEVSSTTQPIEPT--KRSLRVQTWKKIQEGKVGIGFNNIFNRIPSFVGADKAAA 72
            |.|.|:...||::...:....:|.  |..:|.:.|..::.....:....:.:|||:||||..||.
plant    66 AAAMEDMAETAKKELESDPDSDPKAWKWVIRKKMWDLMEARNYAMSPRPVHHRIPNFVGASAAAR 130

  Fly    73 LFANEEEFKKAQHIKVNIDRVLHEFKELALLADKSVYLPSTRESSAL--CLKVDVLADATEEQKK 135
            ..|..:.|:.|..:|||.|....:.:.|.|..:|.:..|..|..:..  .|:.|:|   ..|...
plant   131 KLAELDAFRMAMVVKVNPDSPQKQIRFLTLSGEKKLLTPQPRLRTGFFSVLESDLL---KPETIM 192

  Fly   136 EALRVQDIQKFRSEIGLDSGLKLDIVVIGSVVVS-REGYRIGRGNGFADLDIGLLIELGAITPKT 199
            ||.....:.|:...||||..:|:|::|||||.|: :.|.|:|:|.|||:|:.|:|..:|||...|
plant   193 EACTSVGVAKYGRAIGLDEKIKVDLIVIGSVAVNPQTGARLGKGEGFAELEYGMLRYMGAIDDST 257

  Fly   200 IIVTIVHDMQVVDSLPPNLFQKYDTPVDIIATPTEIIRVPKRLSFPNGVYWELLSERRLKILPVL 264
            .:||.|||.|:||.:|......:|.|||||.|||.:|.....:..|.|:||:.||..:|:.:.:|
plant   258 PVVTTVHDCQLVDDIPLEKLAIHDVPVDIICTPTRVIFTNTPIPKPQGIYWDKLSPEKLRQIRIL 322

  Fly   265 QQLKER-EEKAGKSI 278
            ::||.| |:|.|:.:
plant   323 RELKNRLEKKTGRKL 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lost	NP_649466.1	5-FTHF_cyc-lig	67..238	CDD:294257	67/173 (39%)
lost	NP_649466.1	RRM_MTHFSD	384..455	CDD:240716
COG0212	NP_565139.1	5-FTHF_cyc-lig	92..290	CDD:396398	72/200 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	121	1.000	Domainoid score	I1872
eggNOG	1	0.900	-	-		E1_COG0212
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11245
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1137978at2759
OrthoFinder	1	1.000	-	-		FOG0006138
OrthoInspector	1	1.000	-	-		oto3741
orthoMCL	1	0.900	-	-		OOG6_105117
Panther	1	1.100	-	-	LDO	PTHR13017
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4426
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.780