Protein Alignment lost and mthfsd

DIOPT Version :9

• Sequence 1: NP_649466.1
• Gene: lost / 40559
• FlyBaseID: FBgn0263594
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: NP_001038564.1
• Gene: mthfsd / 566203
• ZFINID: ZDB-GENE-030131-3513
• Length: 382
• Species: Danio rerio
• Alignment Length: 431
• Identity: 119/431 - (27%)
• Similarity: 190/431 - (44%)
• Gaps: 120/431 - (27%)

  Fly    33 TKRSLRVQTWKKIQEGKVGIGFNNIFNRIPSFVGADKAAALFANEEEFKKAQHIKVNIDRVLHEF 97
            ||..:|.:.|..|:...:......:.||||:|.||.:|....|..|.|.::..:||:.|:.:...
Zfish    12 TKWDVRHKVWNYIEVKNLANFPRPVHNRIPNFKGALEACNKVAQLEIFIESAVVKVDPDKPMEGV 76

  Fly    98 KELALLADKSVYLPSTRESSALCLKVDVLADATEEQKKEALRV----QDIQKFRSEIGLDSGLKL 158
            :..||.|.||:.:|:.|....|..::.....||    ||.|||    |.|::|...:|||..:::
Zfish    77 RLAALKARKSLLVPTPRLRFGLFNRITPPKGAT----KETLRVCSTSQGIKEFSVPVGLDDKVQV 137

  Fly   159 DIVVIGSVVVSREGYRIGRGNGFADLDIGLLIELGAITPKTIIVTIVHDMQVVDSLPPNLFQKYD 223
            |:||:|||.||.:|||||:|.||||::..::..:|::|..|.::|:|||.||:| :|..|.:::|
Zfish   138 DLVVVGSVAVSEKGYRIGKGEGFADMEYAMMACMGSVTESTWVITVVHDCQVMD-IPEELIERHD 201

  Fly   224 TPVDIIATPTEIIRVPKRLSFPNGVYWELLSERRLKILPVLQQLKEREEKAGKSISLKEEDTDVE 288
            ..||.|.|.|.:|:...:...|.|:.|.:|.:..||.:|:|::|:..|::|||.::|
Zfish   202 LMVDFIITATRVIKTECKHPKPQGIIWSMLHKEELKKIPILKKLRTLEQEAGKDVAL-------- 258

  Fly   289 QHQNNRRRRGPVRRRIQRGNPGRTTSQTDNEQPQGETAQKRTPRRKGRFVNRRRRTTKSEGDQSG 353
                                                                             
Zfish   259 ----------------------------------------------------------------- 258

  Fly   354 VEAGAKTDDRKLPEAGTDERRSKKN-----------------KNSDFC-----------IKLTNL 390
                      ||..||.||.|..|.                 .|||.|           :.|:::
Zfish   259 ----------KLIHAGEDEYRKSKELQWQSHPKADLEFKCLASNSDRCSGFEPKFPTTTVYLSDI 313

  Fly   391 SRDIRVKDLKSELRKRECTPMSISWKGHFGKCFLHFGNRKG 431
            ...:||.:||..||::|..|:.|.|:|...|.||.:.:..|
Zfish   314 PPALRVSELKGLLREQEVVPLQIRWQGAKRKAFLLYADFTG 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lost	NP_649466.1	5-FTHF_cyc-lig	67..238	CDD:294257	66/174 (38%)
		RRM_MTHFSD	384..455	CDD:240716	17/59 (29%)
mthfsd	NP_001038564.1	5-FTHF_cyc-lig	17..214	CDD:294257	74/201 (37%)
		RRM_MTHFSD	307..378	CDD:240716	16/48 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576383
Domainoid	1	1.000	124	1.000	Domainoid score	I5477
eggNOG	1	0.900	-	-		E1_COG0212
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11245
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3724
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1137978at2759
OrthoFinder	1	1.000	-	-		FOG0006138
OrthoInspector	1	1.000	-	-		oto40758
orthoMCL	1	0.900	-	-		OOG6_105117
Panther	1	1.100	-	-	LDO	PTHR13017
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9603
SonicParanoid	1	1.000	-	-		X4426
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790