Protein Alignment lost and Mthfsd

DIOPT Version :9

• Sequence 1: NP_649466.1
• Gene: lost / 40559
• FlyBaseID: FBgn0263594
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: XP_006530998.1
• Gene: Mthfsd / 234814
• MGIID: 2679252
• Length: 444
• Species: Mus musculus
• Alignment Length: 426
• Identity: 126/426 - (29%)
• Similarity: 209/426 - (49%)
• Gaps: 81/426 - (19%)

  Fly     5 SNAAPAVAAENGGNTAQEVSSTTQPIEPTKRSLRVQTWKKIQEGKVGIGFNNIFNRIPSFVGADK 69
            |.:||  ||:.|..|...||         |:|:|.:.|..::...:......:.:|||:|.|:..
Mouse    63 STSAP--AAKVGKATIAGVS---------KQSIRERIWDYMESHDIADFPRPVHHRIPNFKGSYL 116

  Fly    70 AAALFANEEEFKKAQHIKVNIDRVLHEFKELALLADKSVYLPSTRESSALCLKVDVLADATEEQK 134
            |.....:.|.|...|.:||:.|:.|...:.|||.:.|::.:|:.|..:.|..|:.....||::..
Mouse   117 AGQSIRDLEVFAGTQEVKVDPDKPLEGVRFLALQSKKTLLVPTPRLRTGLFNKITPPPGATKDIL 181

  Fly   135 KEALRVQDIQKFRSEIGLDSGLKLDIVVIGSVVVSREGYRIGRGNGFADLDIGLLIELGAITPKT 199
            ::....|.::.|...:||||.:.:|:||:|||.||.:|:|||:|.|:|||:..:::.:||:...|
Mouse   182 RKCATSQGVRNFSVPVGLDSSVLVDLVVVGSVAVSEKGWRIGKGEGYADLEYAMMVSMGAVHKGT 246

  Fly   200 IIVTIVHDMQVVDSLPPNLFQKYDTPVDIIATPTEIIRV----PKRLSFPNGVYWELLSERRLKI 260
            .:||||||.|||| :|..|.:.:|..||.|.|||.:|..    ||    |.|:.|..:|...|..
Mouse   247 PVVTIVHDCQVVD-IPEALVEDHDLTVDYILTPTRVITTGCARPK----PTGIMWSKVSCEMLTK 306

  Fly   261 LPVLQQLKEREEKAGKSISLKEEDTDVEQHQNNRRRRGPVRRRIQRGNPGRTTSQTDNEQPQGET 325
            :|||:.|:|||::|||.::|::|.      .:.:...||:||                  ||
Mouse   307 IPVLRNLREREKQAGKDVTLRDEP------GSQQPAPGPIRR------------------PQ--- 344

  Fly   326 AQKRTPRRKGRFVNRRRRTTKSEGDQSGVEAGAKTDDRKLPEAGTDERRSKKNKNSDFCIKLTNL 390
                                  :..|:|...|:::     |..|.|.:.:     :..|:  .||
Mouse   345 ----------------------DRPQTGSRGGSRS-----PLQGADTQLA-----ATVCV--GNL 375

  Fly   391 SRDIRVKDLKSELRKRECTPMSISWKGHFGKCFLHF 426
            ....||::||..|::....|:.::|:|...:..||:
Mouse   376 PFTTRVRELKRVLQELGVVPLRLTWQGPQHRAVLHY 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lost	NP_649466.1	5-FTHF_cyc-lig	67..238	CDD:294257	64/170 (38%)
		RRM_MTHFSD	384..455	CDD:240716	13/43 (30%)
Mthfsd	XP_006530998.1	5-FTHF_cyc-lig	81..278	CDD:381971	69/197 (35%)
		RRM_SF	369..438	CDD:388407	13/45 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833672
Domainoid	1	1.000	130	1.000	Domainoid score	I5199
eggNOG	1	0.900	-	-		E1_COG0212
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11245
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4105
Isobase	1	0.950	-	0	Normalized mean entropy	S7734
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006138
OrthoInspector	1	1.000	-	-		oto93614
orthoMCL	1	0.900	-	-		OOG6_105117
Panther	1	1.100	-	-	LDO	PTHR13017
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9603
SonicParanoid	1	1.000	-	-		X4426
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.730