Protein Alignment lost and Mthfs

DIOPT Version :9

• Sequence 1: NP_649466.1
• Gene: lost / 40559
• FlyBaseID: FBgn0263594
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: NP_081105.1
• Gene: Mthfs / 107885
• MGIID: 1340032
• Length: 203
• Species: Mus musculus
• Alignment Length: 224
• Identity: 46/224 - (20%)
• Similarity: 80/224 - (35%)
• Gaps: 72/224 - (32%)

  Fly    30 IEPTKRSLRVQTWKKIQ--------------EGKVGIGFNNIFN--RIPSFVG-ADKAAALFANE 77
            :...||.||.:..::::              ..|| |..|...|  ||..|:. .|:.......:
Mouse     6 VNSAKRGLRAELKQRLRALSAEERLRQSLLLTQKV-IAHNQYQNSKRISIFLSMQDEVETEVIIK 69

  Fly    78 EEFKKA--------QHIKVNIDRV-LHEFKELALLADKS--VYLPSTRESSALCLKVDVLADATE 131
            :.||:.        |....::|.| |...:|:|||...|  ::.|..             .|..|
Mouse    70 DIFKQGKICFIPRYQFQSNHMDMVRLTSSEEIALLPKTSWNIHQPGE-------------GDVRE 121

  Fly   132 EQKKEALRVQDIQKFRSEIGLDSGLKLDIVVIGSVVVSREGYRIGRGNGFADLDIGLLIELGAIT 196
            |                  .|.:| .||::.:..:...::|.|:|||.|:.|..:...::...:.
Mouse   122 E------------------ALSTG-GLDLIFLPGLGFDKDGNRLGRGKGYYDTYLKRCVQHQEVK 167

  Fly   197 PKTIIVTI-----------VHDMQVVDSL 214
            |.|:.:..           .|||:|.:.|
Mouse   168 PYTMALAFKEQICPQIPVDEHDMKVDEVL 196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lost	NP_649466.1	5-FTHF_cyc-lig	67..238	CDD:294257	34/170 (20%)
		RRM_MTHFSD	384..455	CDD:240716
Mthfs	NP_081105.1	5-FTHF_cyc-lig	10..198	CDD:280059	46/220 (21%)
		Substrate binding. /evidence=ECO:0000250	148..152		2/3 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0212
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900