Protein Alignment lost and mthfsd

DIOPT Version :10

• Sequence 1: NP_649466.1
• Gene: lost / 40559
• FlyBaseID: FBgn0263594
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: NP_001106431.1
• Gene: mthfsd / 100127601
• XenbaseID: XB-GENE-5787582
• Length: 415
• Species: Xenopus tropicalis
• Alignment Length: 434
• Identity: 121/434 - (27%)
• Similarity: 214/434 - (49%)
• Gaps: 71/434 - (16%)

  Fly    30 IEP--TKRSLRVQTWKKIQEGKVGIGFNNIFNRIPSFVGADKAAALFANEEEFKKAQHIKVNIDR 92
            :||  :|..:|.:.|..|:...:......:.:|||:|..:.:|.....:.|.|::.:.:||:.|:
 Frog     7 VEPGCSKWDIRQKVWDHIENNNLADFPRPVHHRIPNFKVSRQACQKITDLEIFRRTREVKVDPDK 71

  Fly    93 VLHEFKELALLADKSVYLPSTRESSALCLKVDVLADATEEQKKEALRV----QDIQKFRSEIGLD 153
            .|...:..||.|.|::.:|:.|..:.|..|:...:.|    .||.||:    |.::.:...:|||
 Frog    72 PLEGVRLAALQAHKTLLVPTPRLRTGLFNKITPPSGA----NKEVLRICSTSQGVRDYSVPMGLD 132

  Fly   154 SGLKLDIVVIGSVVVSREGYRIGRGNGFADLDIGLLIELGAITPKTIIVTIVHDMQVVDSLPPNL 218
            :.:::|:||:|||.||.||:|||:|.||||::..:::.:||:|..|::||:|||.|||| :|..|
 Frog   133 AKVQVDLVVVGSVAVSVEGWRIGKGEGFADMEYAMMVSMGAVTEHTVVVTVVHDCQVVD-IPEEL 196

  Fly   219 FQKYDTPVDIIATPTEIIRVPKRLSFPNGVYWELLSERRLKILPVLQQLKEREEKAGKSISLKEE 283
            .:.:|..||.|.|||.||:...:.:.|.|:.|.:::...:..:|:|:.|::||.|||:.:|||:|
 Frog   197 LEDHDLTVDFILTPTRIIKTDCKRAKPQGIIWSMITREMMAKIPILRNLQDRERKAGRDVSLKDE 261

  Fly   284 DTDVEQHQNNRRRRGPVRRRIQRGNPGRTTSQTDNEQPQGETAQKRTPRRKGRFVNRRRRTTKSE 348
                     |...:|                  ..:.|.|.|.::..|
 Frog   262 ---------NASEKG------------------TRQSPFGVTEKEVRP----------------- 282

  Fly   349 GDQSGVEAGAKTDDRKLPEAGTDERRSKK----NKNSDFCIKLTNLSRDIRVKDLKSELRKRECT 409
                   .|:...:.|.|   .|.:...|    |......:.:.|:....||.:|||.||:|...
 Frog   283 -------CGSVLSEHKHP---ADVQLHTKLETCNLYDGVTVYIGNIPSSTRVSELKSMLRERGAA 337

  Fly   410 PMSISWKGHFGKCFLHFGNRKGVPSTQDDMDKVLKSLNDLSLTI 453
            |:.::|:|...:.||.:.:..........::.:  |:|.:||.:
 Frog   338 PLRLTWQGAQHRAFLDYKDVVQAKQAVSSLEGI--SINGISLLV 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lost	NP_649466.1	5-FTHF_cyc-lig	34..232	CDD:444864	69/201 (34%)
		RRM_SF	384..455	CDD:473069	18/70 (26%)
mthfsd	NP_001106431.1	5-FTHF_cyc-lig	13..210	CDD:444864	69/201 (34%)
		RRM_MTHFSD	312..383	CDD:409713	18/70 (26%)