Protein Alignment Cont and BSG

DIOPT Version :10

• Sequence 1: NP_649461.2
• Gene: Cont / 40553
• FlyBaseID: FBgn0037240
• Length: 1390
• Species: Drosophila melanogaster
• Sequence 2: NP_001719.2
• Gene: BSG / 682
• HGNCID: 1116
• Length: 385
• Species: Homo sapiens
• Alignment Length: 355
• Identity: 76/355 - (21%)
• Similarity: 118/355 - (33%)
• Gaps: 117/355 - (32%)

  Fly   579 FPEAPVA-----GDEIRLECMAFGYPIPSYNWTRQ-------------GLPLQR----NAYTINY 621
            |.:||::     |..:.|.|.|.|.|:|...|..:             |..|.|    ..|..:.
Human    25 FVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHA 89

  Fly   622 GRVLIIQNATTNDNGEYSCTITN----------PRKTLMKSIYINIQMRP--QFTIPLKDMIKDY 674
            ...:.|......|.|.|.|..:|          ||...:::..:.:.:.|  .||     .::|.
Human    90 ASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFT-----TVEDL 149

  Fly   675 NSDVTFICEA--FAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLE--KDKDD--AMYQ 733
            .|.:...|..  .|.....:.|.|..            .:::::.|..:..|  .|.||  ..|.
Human   150 GSKILLTCSLNDSATEVTGHRWLKGG------------VVLKEDALPGQKTEFKVDSDDQWGEYS 202

  Fly   734 C-------GAQNQLKTSFSSAQL----RVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRP 787
            |       |..|        .||    ||.::|.|  :|..|.|       ...:||..|:.| |
Human   203 CVFLPEPMGTAN--------IQLHGPPRVKAVKSS--EHINEGE-------TAMLVCKSESVP-P 249

  Fly   788 KFQW------KKDGQVIGSGGHRRILPSGT-----LTISPTSRD-DEGIYTCIASNQAGTDE--- 837
            ...|      ..:.:.:.:|...|...|.:     |.|...:.: |.|.|.|..::..|:|:
Human   250 VTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAII 314

  Fly   838 -----SH-----------ARVIVLQEIRFI 851
                 ||           |.|:||..|.||
Human   315 TLRVRSHLAALWPFLGIVAEVLVLVTIIFI 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..466	CDD:472250
		Ig strand B	384..388	CDD:409356
		Ig strand C	397..409	CDD:409356
		Ig strand E	428..432	CDD:409356
		Ig strand F	443..448	CDD:409356
		Ig strand G	457..460	CDD:409356
		Ig	474..559	CDD:472250
		Ig strand B	485..489	CDD:409392
		Ig strand C	499..503	CDD:409392
		Ig strand E	523..527	CDD:409392
		Ig strand F	537..542	CDD:409392
		Ig strand G	553..556	CDD:409392
		Ig_3	584..644	CDD:464046	17/81 (21%)
		Ig_3	660..738	CDD:464046	17/92 (18%)
		Ig	756..844	CDD:472250	25/118 (21%)
		Ig strand B	775..779	CDD:409358	0/3 (0%)
		Ig strand C	788..792	CDD:409358	1/9 (11%)
		Ig strand E	810..814	CDD:409358	1/8 (13%)
		Ig strand F	824..829	CDD:409358	2/4 (50%)
		Ig strand G	837..840	CDD:409358	2/21 (10%)
		Ig	<868..944	CDD:472250
		Ig strand C	881..885	CDD:409359
		Ig strand E	906..910	CDD:409359
		Ig strand F	920..925	CDD:409359
		Ig strand G	933..936	CDD:409359
		FN3	944..1043	CDD:238020
		FN3	1053..1146	CDD:238020
		fn3	1156..1244	CDD:394996
		fn3	1259..1346	CDD:394996
BSG	NP_001719.2	Ig0_BSG1	23..138	CDD:409534	23/112 (21%)
		Ig strand A	24..28	CDD:409534	1/2 (50%)
		Ig strand A'	29..35	CDD:409534	1/5 (20%)
		Ig strand B	38..47	CDD:409534	2/8 (25%)
		Ig strand C	52..60	CDD:409534	2/7 (29%)
		Ig strand C'	65..69	CDD:409534	0/3 (0%)
		Ig strand D	79..85	CDD:409534	0/5 (0%)
		Ig strand E	88..97	CDD:409534	1/8 (13%)
		Ig strand F	104..112	CDD:409534	3/7 (43%)
		Ig strand G	128..138	CDD:409534	0/9 (0%)
		Essential for interaction with KDR/VEGFR2. /evidence=ECO:0000269|PubMed:25825981	195..199		2/3 (67%)
		IG_like	228..318	CDD:214653	21/99 (21%)
		Ig strand B	238..242	CDD:409353	0/3 (0%)
		Ig strand E	283..287	CDD:409353	1/3 (33%)
		Ig strand F	298..303	CDD:409353	2/4 (50%)
		Ig strand G	311..314	CDD:409353	0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..385