DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cont and ROBO3

DIOPT Version :10

Sequence 1:NP_649461.2 Gene:Cont / 40553 FlyBaseID:FBgn0037240 Length:1390 Species:Drosophila melanogaster
Sequence 2:NP_071765.2 Gene:ROBO3 / 64221 HGNCID:13433 Length:1386 Species:Homo sapiens


Alignment Length:1040 Identity:234/1040 - (22%)
Similarity:366/1040 - (35%) Gaps:305/1040 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   318 IELNLF-------ICESKVLYSSDNVNIK------LDDKRPYHYGLDINDMERIPRGPYFVKQPN 369
            :::|||       |..|..|....|.::.      |....|...|..:...:.:||   .|:||.
Human    10 LQMNLFADSLAGDISNSSELLLGFNSSLAALNHTLLPPGDPSLNGSRVGPEDAMPR---IVEQPP 71

  Fly   370 DTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTISGGNL---- 430
            |..  |::.   ...||.|.|.|.|.|:..||:.   ..|:...:.||.|. |..:..|.|    
Human    72 DLL--VSRG---EPATLPCRAEGRPRPNIEWYKN---GARVATVREDPRAH-RLLLPSGALFFPR 127

  Fly   431 IIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLKRSAETSEMNWGKSIFCDPPQHY 495
            |::..:...|:|.|.|||.|..|...|.:|.|                                 
Human   128 IVHGRRARPDEGVYTCVARNYLGAAASRNASL--------------------------------- 159

  Fly   496 PDVRYYWARDYFPNFVEEDQRVFVSRDGALYFSFIETVDRANYSCTVQTLVSDTGRNGPFFPLRV 560
                                .|.|.||                                  ..|.
Human   160 --------------------EVAVLRD----------------------------------DFRQ 170

  Fly   561 TPNSNYQALIFANTFPKVFPEAPVAGDEIRLECM-AFGYPIPSYNWTRQGLPL--QRNAYTINYG 622
            :|.:...|:                |:...|||: ..|:|.||.:|.:.|..|  :....||..|
Human   171 SPGNVVVAV----------------GEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGG 219

  Fly   623 RVLIIQNATTNDNGEYSCTITN---PRKTLMKSIYI----NIQMRPQFTIPLKDMIKDYNSDVTF 680
            : |::.:...:|.|.|.|..:|   .|::....:.:    :...||...:.|.|      :.|||
Human   220 K-LMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLAD------APVTF 277

  Fly   681 ICEAFAIPDANYTWYKNAERLDPANINRDRYIIQ-DNVLTIKFLEKDKDDAMYQCGAQNQLKTSF 744
            :||....|.....|     |.:...:...||.|: |:.|.|..:..: |:..|.|.|:|.:..:.
Human   278 LCEVKGDPPPRLRW-----RKEDGELPTGRYEIRSDHSLWIGHVSAE-DEGTYTCVAENSVGRAE 336

  Fly   745 SSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDG--------QVIGSG 801
            :|..|.| .:.|.....|  .:..|....:....|:.:..|.|...|:|:|        |.:...
Human   337 ASGSLSV-HVPPQLVTQP--QDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPT 398

  Fly   802 GHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIE---TPP-------- 855
            |...:.|.|.|.|:...|.|.|.|.|.|.:.||:..:.|    |.||:...   .||        
Human   399 GRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKA----LLEIKGASLDGLPPVILQGPAN 459

  Fly   856 QRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVL-------KNNHDGTGRIIVDWNRLTVHNT 913
            |.:|....  ::|.|....:....:.  ||.:|:.|       |...:||         |.:.|.
Human   460 QTLVLGSS--VWLPCRVTGNPQPSVR--WKKDGQWLQGDDLQFKTMANGT---------LYIANV 511

  Fly   914 SMRDAGDYECVVKSAVNE--------------ISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEW 964
            ...|.|.|.||.||:..|              :|..........||||....|.:|:|....:.|
Human   512 QEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTW 576

  Fly   965 VDGSHNGRAIRYYNI------LGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEF 1023
            ......|.|:..|.|      .|     .||..|:..||   ::.:|      |..|.|.:.|.|
Human   577 KPNPQTGAAVTSYVIEAFSPAAG-----NTWRTVADGVQ---LETHT------VSGLQPNTIYLF 627

  Fly  1024 SVTAVNDLGIGTPSAPSPIYSTYEDKP-------------------------YIAPRNVGGGGGK 1063
            .|.||...|:..||..|....|.:..|                         .:.||.       
Human   628 LVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRT------- 685

  Fly  1064 IGDLTITW---DPLLPQEQHSHGIHYKVFWKLKG--AIEWASDEIKKQDHMGVAVVNIPLNNYYT 1123
               |.::|   .|:    |...|  ::|.|::.|  ...|...:::........:..:|..   |
Human   686 ---LQVSWTVDGPV----QLVQG--FRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPG---T 738

  Fly  1124 EYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKP---IALAY---NSTCFNVTWQPIDMSRE 1182
            :.::||||....|.|.|| ::|..|   :|:.||..|   :|:|.   .::...|:|:|...|::
Human   739 QIQIKVQAQGQEGLGAES-LSVTRS---IPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQ 799

  Fly  1183 NIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNW---ALIVGLQPDTYYFVKVMAYNAAGEGPES 1244
            |  |.:..:::  |...:   :|.::|:|:...|   |::.||.|...|...|.|..:||.|..|
Human   800 N--GVITEYQI--WCLGN---ESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPS 857

  Fly  1245  1244
            Human   858  857

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ContNP_649461.2 CLECT 139..>223 CDD:214480
Ig 361..466 CDD:472250 33/108 (31%)
Ig strand B 384..388 CDD:409356 2/3 (67%)
Ig strand C 397..409 CDD:409356 2/11 (18%)
Ig strand E 428..432 CDD:409356 2/7 (29%)
Ig strand F 443..448 CDD:409356 2/4 (50%)
Ig strand G 457..460 CDD:409356 1/2 (50%)
Ig 474..559 CDD:472250 4/84 (5%)
Ig strand B 485..489 CDD:409392 0/3 (0%)
Ig strand C 499..503 CDD:409392 0/3 (0%)
Ig strand E 523..527 CDD:409392 0/3 (0%)
Ig strand F 537..542 CDD:409392 0/4 (0%)
Ig strand G 553..556 CDD:409392 0/2 (0%)
Ig_3 584..644 CDD:464046 19/62 (31%)
Ig_3 660..738 CDD:464046 22/78 (28%)
Ig 756..844 CDD:472250 24/95 (25%)
Ig strand B 775..779 CDD:409358 0/3 (0%)
Ig strand C 788..792 CDD:409358 0/3 (0%)
Ig strand E 810..814 CDD:409358 2/3 (67%)
Ig strand F 824..829 CDD:409358 2/4 (50%)
Ig strand G 837..840 CDD:409358 0/2 (0%)
Ig <868..944 CDD:472250 20/96 (21%)
Ig strand C 881..885 CDD:409359 0/3 (0%)
Ig strand E 906..910 CDD:409359 1/3 (33%)
Ig strand F 920..925 CDD:409359 2/4 (50%)
Ig strand G 933..936 CDD:409359 1/2 (50%)
FN3 944..1043 CDD:238020 31/104 (30%)
FN3 1053..1146 CDD:238020 21/97 (22%)
fn3 1156..1244 CDD:394996 26/96 (27%)
fn3 1259..1346 CDD:394996
ROBO3NP_071765.2 Ig 64..162 CDD:472250 35/162 (22%)
Ig strand B 81..85 CDD:409353 2/3 (67%)
Ig strand C 94..98 CDD:409353 0/3 (0%)
Ig strand E 121..125 CDD:409353 2/3 (67%)
Ig strand F 140..145 CDD:409353 2/4 (50%)
Ig strand G 154..157 CDD:409353 1/2 (50%)
Ig 169..254 CDD:472250 24/101 (24%)
Ig strand B 183..187 CDD:409353 1/3 (33%)
Ig strand C 197..201 CDD:409353 1/3 (33%)
Ig strand E 219..223 CDD:409353 2/4 (50%)
Ig strand F 233..238 CDD:409353 2/4 (50%)
Ig strand G 247..250 CDD:409353 0/2 (0%)
Ig 261..343 CDD:472250 25/93 (27%)
Ig strand B 275..279 CDD:409353 3/3 (100%)
Ig strand C 288..292 CDD:409353 1/8 (13%)
Ig strand E 309..313 CDD:409353 1/3 (33%)
Ig strand F 323..328 CDD:409353 2/4 (50%)
Ig strand G 336..339 CDD:409353 0/2 (0%)
Ig 348..445 CDD:472250 26/102 (25%)
Ig strand B 364..368 CDD:409353 0/3 (0%)
Ig strand C 377..381 CDD:409353 0/3 (0%)
Ig strand E 407..411 CDD:409353 2/3 (67%)
Ig strand F 421..426 CDD:409353 2/4 (50%)
Ig strand G 434..437 CDD:409353 0/2 (0%)
Ig 452..536 CDD:472250 21/96 (22%)
Ig strand B 468..472 CDD:409353 1/3 (33%)
Ig strand C 481..485 CDD:409353 0/5 (0%)
Ig strand E 504..508 CDD:409353 3/12 (25%)
FN3 <518..>809 CDD:442628 75/331 (23%)
Ig strand F 518..523 CDD:409353 2/4 (50%)
Ig strand G 531..534 CDD:409353 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 541..563 5/21 (24%)
FN3 556..649 CDD:238020 31/106 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..662 5/22 (23%)
FN3 770..863 CDD:238020 25/95 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 965..989
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1028..1310
PRK12323 <1126..1325 CDD:481241
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1327..1386
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.