DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cont and IGSF9

DIOPT Version :10

Sequence 1:NP_649461.2 Gene:Cont / 40553 FlyBaseID:FBgn0037240 Length:1390 Species:Drosophila melanogaster
Sequence 2:NP_001128522.1 Gene:IGSF9 / 57549 HGNCID:18132 Length:1179 Species:Homo sapiens


Alignment Length:797 Identity:190/797 - (23%)
Similarity:299/797 - (37%) Gaps:195/797 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   484 GKSIF--CD-------PPQHYPDVRYYWARDYF----------------PNFVEEDQRVFVSRDG 523
            |:|:.  ||       ||.|..:    |.|..|                |::|   .||.:.:..
Human    34 GESVVLGCDLLPPAGRPPLHVIE----WLRFGFLLPIFIQFGLYSPRIDPDYV---GRVRLQKGA 91

  Fly   524 ALYFSFIETVDRANYSCTV----QTLVSDTGRNGPFFPLRVTPNSNYQALIFANTFPKVFPEAPV 584
            :|....:...|:..|.|.|    |.:..|...||.:  :.:|.||           |..|.|.|.
Human    92 SLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSW--VHLTVNS-----------PPQFQETPP 143

  Fly   585 AGDEIR------LECMAFGYPIPSYNWTRQGLPLQRNAYTINYGRVLIIQNAT-------TNDNG 636
            |..|::      |.|:|.|.|:|...|..:|..|.:     ..|:|. :||.|       ...:|
Human   144 AVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQ-----GQGQVQ-VQNGTLRIRRVERGSSG 202

  Fly   637 EYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIP-DANYTWYK---- 696
            .|:|..::...:...:..:.:...|...:|.|:...:.:.||:..|.|.|.| :..|:|::    
Human   203 VYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNIN 267

  Fly   697 --NAERLDPANINRDRYIIQDNVLTIKFLEKDKDDA-MYQCGAQN-QLKTSFSSAQLRVL----- 752
              :..||.|    |.|.::..   :::.|....||| .|.|...| .|....:||.|.||     
Human   268 VFHISRLQP----RVRILVDG---SLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQV 325

  Fly   753 -SMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKF-QWKKDGQVI-------GSGGHRRILP 808
             :|.|   :.||...:..|      |.|...|.|...| .|.|||:.:       .|.|     .
Human   326 TAMPP---ETPLPIGMPGV------IRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQG-----T 376

  Fly   809 SGTLTISPTSRDDEGIYTCIASNQAGT--DESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCE 871
            .|:|.|:..:.|..|.|:|...|..||  .....||::.....|||.|.:....:....:.:.|.
Human   377 EGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCS 441

  Fly   872 AAFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNRLTVHNTSMRDA-GDYECVVKSAVNEISSK 935
            |..|....::  |...|..|:      |:..||.|...:.....::| |.:||...:||..:::.
Human   442 AQGDPPPVVS--WTKVGRGLQ------GQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATS 498

  Fly   936 TSVSIEG-APGAPGGVQVIQISKTKAIIEW---VDGSHNGRAIRYYNILGR--TNWNRTWVNVST 994
            |:|.:.| :|.....|.|:.:.| .|.:.|   .||.:..|...:|..|.:  ...:..||:::.
Human   499 TNVYVLGTSPHVVTNVSVVALPK-GANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAV 562

  Fly   995 HVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIG---------------TPSAPSPIYS 1044
            .|.|..:         .|..|.|.:.|:|||.|.|.||.|               ||:||. :..
Human   563 PVGAAHL---------LVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPG-LPP 617

  Fly  1045 TYEDKPYIAPRNVGGGGGKIGDLTITWDP--LLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQD 1107
            |....|...||.:.......|.| :.|||  |:|:....        :.|:|          :|.
Human   618 TEIPPPLSPPRGLVAVRTPRGVL-LHWDPPELVPKRLDG--------YVLEG----------RQG 663

  Fly  1108 HMGVAVVNIPLNNYYTE-----------YEVKVQAI--------NSVGKGPESEIAVIHSAEDMP 1153
            ..|..|::..:....||           ||.::.|.        ::......|.:.|..|...:|
Human   664 SQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLP 728

  Fly  1154 QVAPQKPIALAYNSTCF 1170
            .:.||..:|......||
Human   729 GLLPQPVLAGVVGGVCF 745

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ContNP_649461.2 CLECT 139..>223 CDD:214480
Ig 361..466 CDD:472250
Ig strand B 384..388 CDD:409356
Ig strand C 397..409 CDD:409356
Ig strand E 428..432 CDD:409356
Ig strand F 443..448 CDD:409356
Ig strand G 457..460 CDD:409356
Ig 474..559 CDD:472250 23/103 (22%)
Ig strand B 485..489 CDD:409392 1/5 (20%)
Ig strand C 499..503 CDD:409392 0/3 (0%)
Ig strand E 523..527 CDD:409392 1/3 (33%)
Ig strand F 537..542 CDD:409392 2/4 (50%)
Ig strand G 553..556 CDD:409392 1/2 (50%)
Ig_3 584..644 CDD:464046 19/72 (26%)
Ig_3 660..738 CDD:464046 22/85 (26%)
Ig 756..844 CDD:472250 27/97 (28%)
Ig strand B 775..779 CDD:409358 1/3 (33%)
Ig strand C 788..792 CDD:409358 1/4 (25%)
Ig strand E 810..814 CDD:409358 2/3 (67%)
Ig strand F 824..829 CDD:409358 2/4 (50%)
Ig strand G 837..840 CDD:409358 0/2 (0%)
Ig <868..944 CDD:472250 19/77 (25%)
Ig strand C 881..885 CDD:409359 0/3 (0%)
Ig strand E 906..910 CDD:409359 1/3 (33%)
Ig strand F 920..925 CDD:409359 2/4 (50%)
Ig strand G 933..936 CDD:409359 0/2 (0%)
FN3 944..1043 CDD:238020 31/118 (26%)
FN3 1053..1146 CDD:238020 20/113 (18%)
fn3 1156..1244 CDD:394996 5/15 (33%)
fn3 1259..1346 CDD:394996
IGSF9NP_001128522.1 IG_like 28..110 CDD:214653 18/82 (22%)
Ig strand B 37..41 CDD:409353 0/3 (0%)
Ig strand C 54..58 CDD:409353 0/7 (0%)
Ig strand E 91..95 CDD:409353 1/3 (33%)
Ig 136..223 CDD:472250 22/92 (24%)
Ig strand B 154..158 CDD:409353 1/3 (33%)
Ig strand C 167..171 CDD:409353 0/3 (0%)
Ig strand E 189..193 CDD:409353 1/3 (33%)
Ig strand F 203..208 CDD:409353 2/4 (50%)
Ig_3 226..305 CDD:464046 22/85 (26%)
Ig <341..404 CDD:472250 21/73 (29%)
Ig strand B 341..344 CDD:409353 2/8 (25%)
Ig strand C 353..358 CDD:409353 1/4 (25%)
Ig strand E 378..382 CDD:409353 2/3 (67%)
Ig strand F 392..397 CDD:409353 2/4 (50%)
Ig 418..503 CDD:472250 22/92 (24%)
Ig strand B 436..440 CDD:409570 0/3 (0%)
Ig strand C 449..453 CDD:409570 0/5 (0%)
Ig strand E 469..473 CDD:409570 0/3 (0%)
FN3 482..>717 CDD:442628 60/264 (23%)
Ig strand F 483..488 CDD:409570 2/4 (50%)
Ig strand G 496..499 CDD:409570 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 606..626 6/20 (30%)
FN3 625..715 CDD:238020 19/108 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..919
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 940..988
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1079
PDZ-binding. /evidence=ECO:0000250 1177..1179
Blue background indicates that the domain is not in the aligned region.

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