DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and cntn4

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_001073520.1	Gene:	cntn4 / 571349	ZFINID:	ZDB-GENE-060929-776	Length:	1028	Species:	Danio rerio

Alignment Length:	1052	Identity:	320/1052 - (30%)
Similarity:	493/1052 - (46%)	Gaps:	92/1052 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 FVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTISGG 428
            |.|||......|:......:|..||.|.|.|.|.|.|        :|....::|.....::::||
Zfish    27 FSKQPGSIVSPVDSMEKSREVVFSCEAQGDPPPFYRW--------KLNGSVVNPKPGSHHSLTGG 83

  Fly   429 NLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNL-KRSAETSEMNWGKSIFCDPP 492
            ||.|....:.:|.|.|.|:|.|.||.|.|..|.|.|.::..|.. |||:.:.....|..:.|.||
Zfish    84 NLRINHLNKDMDAGTYQCLASNSFGTIVSREASLTFAYLENFKTHKRSSVSVREGQGVVLLCGPP 148

  Fly   493 QHYPDVRYYWARDYFPNFVEEDQRVFVSRD-GALYFSFIETVDRANYSCTVQTLVSDTGRNGPFF 556
            .|...:.:.|..:.:|:.|::|.|.|||:: |.||.:.:|..|..||:|.|...|:.|...||..
Zfish   149 PHSGALTFSWIFNEYPSIVKQDSRRFVSQETGNLYIAKVEPSDVGNYTCVVTNTVTKTQVQGPPT 213

  Fly   557 PLRVTPNSNYQALIFANTFPKV---FPE-APVA-GDEIRLECMAFGYPIPSYNWTR-QGLPLQRN 615
            ||.:..:.     :.....||:   ||| ..|| |..:||||.|.|.|:||.:|.| .|:|..|.
Zfish   214 PLILRTDG-----VMGEYEPKIEVQFPEVVQVAKGSTVRLECFALGNPVPSISWRRVDGVPFARK 273

  Fly   616 AYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTF 680
            ........|:.|......|.|.|.|...|.:........::....||.....:|:.|..:..:.:
Zfish   274 VDVRKTSGVMEIPYFQQEDAGTYECVAENSKGRNSVQGKLSFFASPQLIEKPQDVQKPIDDSLVW 338

  Fly   681 ICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFS 745
            .|:|...|..:|.|.||.|.|:|   ..:|..:.:..|:|..|.. .|..||||.|.|:....:|
Zfish   339 ECKATGKPKPSYRWMKNGENLEP---TEERVQVINGALSITHLAL-SDIGMYQCVAGNKYGEVYS 399

  Fly   746 SAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSGGHRRILPSG 810
            :|:|||:::.|.|.::.|:|.......|:..|.|.|:.:||....|:|....:.......:|.||
Zfish   400 NAELRVIAVAPDFSQNQLKSHTLVKEGGDVLIECKPKMSPRGSISWRKGNDALRESSRIAVLESG 464

  Fly   811 TLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAAFD 875
            :|.||..|:.|.|.|||:|.||.|...|...::| :|...|.|.|..:.....:.|.|.|:.::|
Zfish   465 SLRISNVSKSDAGSYTCVARNQFGEASSLGNLLV-KEPTIITTAPNTLDVTVGESIILPCQVSYD 528

  Fly   876 ELLDIAYVWKHNGEVLK-NNHDG----------TGRIIVDWNRLTVHNTSMRDAGDYECVVKSAV 929
            ..|::.:.|..|.:::. .:|.|          .|.|:       :.|..:|.||.|.|.|::.|
Zfish   529 PSLELKFTWFFNEQLIHFGSHGGYFEKVGGQHSAGDIM-------IRNIQLRHAGKYTCAVQTKV 586

  Fly   930 NEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTNWNRTWVNVST 994
            :..|..|.:.:.|.||.|..:.|.:|:.|.|.:.|..|..|...|..|.|..||.::..|..|||
Zfish   587 DSSSIATDLIVRGPPGPPTSIHVEEITDTTATLSWRPGPDNHSPITAYTIQARTPFSLGWQAVST 651

  Fly   995 HVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVGG 1059
            ..:.......|    |.|:.|.||..|||.|.|.|.:|.|.||.||....|.:..|.:.|.||.|
Zfish   652 VPEVVGGSHLT----ATVIELNPWVEYEFRVLASNAVGTGEPSKPSKKARTKDTVPKVTPANVSG 712

  Fly  1060 GGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIPLNNY--- 1121
            |||...:|.|||:|:..:.|:..|..|.|.::..|:..|          |..||.:...:.|
Zfish   713 GGGSRSELVITWEPVPEELQNGAGFGYVVAFRPFGSTGW----------MQAAVPSPEASKYVFK 767

  Fly  1122 ------YTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMS 1180
                  ::.::|||.|.|:.|:||...:..|:|||:.|..||.:..|.:.:::...|:|:.:..|
Zfish   768 NETILPFSPFQVKVGAYNNKGEGPFGPVITIYSAEEEPGRAPSRLRAKSLSASDVEVSWKALPWS 832

  Fly  1181 RENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESE 1245
            ..  :.:::|:.|:||:...:|:.|....:...|..|:|.||:..:.|::.|.|||.||.||.|.
Zfish   833 TS--KKRVLGYELRYWEKNEKEDASSVLRTVGNRTLAIIQGLKGSSTYYITVRAYNTAGTGPPSP 895

  Fly  1246 RFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKV---RIWESDQNMITAN 1307
            .....|.:..|.:|||.| ::..:.|.:.:.|..|.|.::|..|.||||   |...|..|::..|
Zfish   896 VVNITTKKPPPSQPPSKV-MWNTSNSKIILNWEQVKPLENESEVMGYKVMYRRNRFSRPNVMETN 959

  Fly  1308 NTIVPIGQKLESYINNLTPGKSYNMRVLAYSNGGDGRMSSPTLHFQMGKTTRNGANTRHGHNINT 1372
            .|.|.:         :|...:.|.:::..:..||:|..|.     |:.....:|.|.     |.:
Zfish   960 TTSVEL---------SLPTDEEYIIQIKPFGEGGEGSSSR-----QITIPRISGPNA-----IGS 1005

  Fly  1373 ALILSTLLLIST 1384
            |..:|||..:||
Zfish  1006 ASSVSTLSALST 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	31/95 (33%)
		I-set	362..462	CDD:254352	32/97 (33%)
		Ig	466..559	CDD:299845	31/94 (33%)
		IG_like	584..657	CDD:214653	24/74 (32%)
		IGc2	586..645	CDD:197706	21/59 (36%)
		Ig	667..751	CDD:299845	26/83 (31%)
		IG_like	676..751	CDD:214653	24/74 (32%)
		IG_like	765..844	CDD:214653	26/78 (33%)
		Ig	773..844	CDD:299845	25/70 (36%)
		I-set	851..940	CDD:254352	24/99 (24%)
		Ig	866..944	CDD:299845	22/88 (25%)
		FN3	944..1043	CDD:238020	37/98 (38%)
		FN3	1053..1146	CDD:238020	30/101 (30%)
		fn3	1156..1244	CDD:278470	26/87 (30%)
		fn3	1259..1346	CDD:278470	25/89 (28%)
cntn4	NP_001073520.1	I-set	26..118	CDD:254352	32/98 (33%)
		Ig	26..116	CDD:299845	31/96 (32%)
		Ig	121..216	CDD:299845	31/94 (33%)
		IG_like	131..207	CDD:214653	24/75 (32%)
		Ig	228..316	CDD:299845	29/87 (33%)
		I-set	228..309	CDD:254352	29/80 (36%)
		I-set	319..405	CDD:254352	28/89 (31%)
		Ig	320..405	CDD:299845	27/88 (31%)
		I-set	410..498	CDD:254352	29/87 (33%)
		Ig	426..498	CDD:299845	25/71 (35%)
		I-set	504..597	CDD:254352	24/99 (24%)
		Ig	517..601	CDD:299845	22/90 (24%)
		FN3	601..693	CDD:238020	35/95 (37%)
		FN3	707..799	CDD:238020	30/101 (30%)
		FN3	808..901	CDD:238020	27/94 (29%)
		FN3	893..994	CDD:238020	30/115 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9761
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1476
OMA	1	1.010	-	-		QHG46028
OrthoDB	1	1.010	-	-		D292460at33208
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		otm24534
orthoMCL	1	0.900	-	-		OOG6_100978
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3370
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.910