DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and dscama

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_021334866.1	Gene:	dscama / 568643	ZFINID:	ZDB-GENE-050310-7	Length:	2025	Species:	Danio rerio

Alignment Length:	1237	Identity:	284/1237 - (22%)
Similarity:	471/1237 - (38%)	Gaps:	239/1237 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 EQVPLENEDLHDNRFLV-------------QNDLNNQNINNPNQFYNSLPGTVNQRNQNNLRGFI 283
            :.|||    :...|||:             :::|.|......:::      |...|..|:.|.|:
Zfish   163 DTVPL----VSGARFLITSTGALYILDVQKEDELFNYRCMTRHRY------TSETRQSNSARLFV 217

  Fly   284 GPNQPYGDNRYVRDRVVYAFSKKRDRWMFMPAYEIELNLFICES------KVLYSSDNVNIKLDD 342
             |..|......:.|    .|.|:.    .|.::.:||.   |::      |..:..:|..::.|.
Zfish   218 -PADPSNSAPAILD----GFEKRE----VMASHRVELP---CKASGHPAPKYRWLKNNRPLESDS 270

  Fly   343 K-RPYHYGLDINDMERIPRGPYF-----------------VKQPNDTTFDVN--KNRLINDVTLS 387
            : |....||.|...:....|.|.                 ||:|........  |..:.:.|:||
Zfish   271 RFRQSVTGLLIERAQPSDTGSYVCEVWNSYGNAEVIGRLTVKEPLKAVVSPRKVKGSVGSQVSLS 335

  Fly   388 CLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYT-ISGGNLIIYEPKQALDQGAYHCVAENK 451
            |...|......:|||        ...||:..|..|.. |:..||:: :.....|.|.|.|
Zfish   336 CSVTGSDEFELSWYR--------NGDKINTGANIRMNGINKENLVM-DGMAKSDGGVYQC----- 386

  Fly   452 FGRIRSESAHLNFGFIMEFNL-KRSAETSEMNWGKSIFCDPPQHY---PDVRYYWARDYFPNFVE 512
            |.|....||......|:|... |..:..||...|.:.|.....|.   |.....|..|  ...|.
Zfish   387 FSRKAKMSAQDFVQVILEDGTPKILSAFSEKVVGPNDFVSLTCHVKGTPQPAITWTLD--DEVVA 449

  Fly   513 EDQR----VFVSRDG----ALYFSFIETVDRANYSCTVQTLVSDTGRNGPFFPLRVTPNSNYQAL 569
            :|.|    ..::.:|    .|..|.|:..|...|.||........               :|||.
Zfish   450 KDSRHRIVHSITAEGNVVSYLNISHIQVRDSGVYRCTCNNSAGTV---------------SYQAR 499

  Fly   570 IFANTFPKVFPE---APVAGDEIRLECMAFGYPIPSYNWTRQG--LPL--QRNAYTINYGRVLII 627
            |.......:.|.   ..:||.::.:.|...|||..|..|.:..  ||.  ::.|:. |.|.:.::
Zfish   500 INVRGSADIRPMKNLTAIAGWDMYIHCHVIGYPYYSIKWFKNSNLLPFNDRQRAFE-NNGTLKLL 563

  Fly   628 QNATTNDNGEYSCTI-TNPRKTLMKSIYINIQMRP---QFTIPLKDMIKDYNSDVTFICEAFAIP 688
            ......|.|||||.: ..|:....:|:::.:::.|   .|..|...:  .:...|..:..:..:|
Zfish   564 NVQKELDEGEYSCHVQVQPQLFKNQSVHVTVKVPPFIQPFEFPRYSI--GHRVFVPCVVRSGDLP 626

  Fly   689 DANYTWYKNAERLDPANINRDRYIIQDNV-----LTIKFLEKDKDDAMYQCGAQNQLKTSFSSAQ 748
             .:.||.|     |..:||....:..||:     |.|..|:: ..:..|.|.|||........:|
Zfish   627 -ISITWEK-----DGKSINASLGVTIDNIDFTSSLRISNLQR-VHNGTYTCIAQNDAAVVKYQSQ 684

  Fly   749 LRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWK--KDGQV-------IGSGGHR 804
            | ::.:.|.||..|.:.:  .:|..:..:.|..:..|||..:||  |...|       :.||...
Zfish   685 L-IVRVPPRFKVQPQDQD--GIYGKSVILNCSADGEPRPTIEWKYSKGAGVPQFQPIALNSGFRV 746

  Fly   805 RILPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLH 869
            ::|.:|:|.|.....:|.|.|.|..||..|.|.|.:..:.::....|.:.|...::.:.:.|.:.
Zfish   747 QLLGNGSLLIKHVLEEDAGYYLCKVSNDVGADVSKSMYLNVKIPAMITSYPNNSLATKGEKIEMS 811

  Fly   870 CEAAFDELLDIAY----------------VWKHNGEVLKNNHDGTGRIIVDWNRLTVHNTSMRDA 918
            |:|..::.:.:.:                :|:|...| ||    .|..:|  :.|.::.|...|:
Zfish   812 CKAHGEKPIMVRWEKEVEKEKQSHMINPDMWRHTVTV-KN----VGDEVV--STLQIYPTMREDS 869

  Fly   919 GDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRT 983
            |.:.|...::..|......:::: .|..|..|::.::.:....:.|..|......|..|:|..:
Zfish   870 GFFSCHAINSYGEDRGILQLTVQ-EPPEPPKVEIREVKERTIALRWTMGFDGNSLITGYDIECK- 932

  Fly   984 NWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYED 1048
            |...||....   :.|:|.  .:..||.::.|.|.|.|...:.|.|.:|...||....: :|.|.
Zfish   933 NKTETWERAR---RTRDVS--PTLNQATIIELHPSSTYNIRMFAKNHIGDSEPSNELTV-TTDEA 991

  Fly  1049 KPYIAPRNVGGGGGKIGDLTITWDPLLP--------------QEQHSHGIHYKVFWKLKGAIEWA 1099
            .|...|::|.........:.:||...|.              :|..::|.|..|...::...|..
Zfish   992 DPEGPPQDVTLEAITSQSIKVTWKAPLKHLQNGVIRGYQVCHREHSTNGSHQFVCISVEATGETE 1056

  Fly  1100 SDEIKKQDHMGVAVVNIPLNNY--YTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIA 1162
            |               :.|||.  :.||||.|||.||.|.||.|......:.||:|..||:|.:|
Zfish  1057 S---------------LSLNNLKKFAEYEVVVQASNSAGPGPASSEVRATTMEDVPSRAPEKVVA 1106

  Fly  1163 LAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWK-------------TTHQEEDSVYYLSRTTR 1214
            .|.:....:::||  ..:||.:.|.|.|.|:.||.             |||:..
Zfish  1107 TAASPESISLSWQ--TPAREALNGVLQGFRIIYWANLPDGELGEIRNVTTHKAP----------- 1158

  Fly  1215 NWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRY 1279
              ..:.||:..|.|.::|:|:..||:|..|::...||....| .||..|.....:.|.|.|.|
Zfish  1159 --LELEGLEKYTNYSIQVLAFTRAGDGVRSDQIYIRTKEDVP-GPPGGVKAAAASSSVVYVSW-- 1218

  Fly  1280 VSPSQDEEPVEGYKVRIWESDQNMITANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSNGGDGR 1344
            :.|.:....:..|.| ...|....:.:...:.|  .:....::||:..:.||:.|:|.:..|.|.
Zfish  1219 LPPLKLNGVIRKYTV-FCSSTSPTVVSEFEVAP--DEFLHRVHNLSRNRKYNIWVMAVTAAGRGN 1280

  Fly  1345 MS 1346
            .|
Zfish  1281 SS 1282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	27/118 (23%)
		I-set	362..462	CDD:254352	28/119 (24%)
		Ig	466..559	CDD:299845	22/104 (21%)
		IG_like	584..657	CDD:214653	21/77 (27%)
		IGc2	586..645	CDD:197706	18/63 (29%)
		Ig	667..751	CDD:299845	20/88 (23%)
		IG_like	676..751	CDD:214653	20/79 (25%)
		IG_like	765..844	CDD:214653	24/87 (28%)
		Ig	773..844	CDD:299845	23/79 (29%)
		I-set	851..940	CDD:254352	18/104 (17%)
		Ig	866..944	CDD:299845	16/93 (17%)
		FN3	944..1043	CDD:238020	24/98 (24%)
		FN3	1053..1146	CDD:238020	27/108 (25%)
		fn3	1156..1244	CDD:278470	27/100 (27%)
		fn3	1259..1346	CDD:278470	20/86 (23%)
dscama	XP_021334866.1	Ig	124..217	CDD:325142	12/63 (19%)
		I-set	236..311	CDD:254352	13/81 (16%)
		IG_like	321..402	CDD:214653	24/94 (26%)
		I-set	408..502	CDD:333254	24/110 (22%)
		IGc2	524..579	CDD:197706	17/55 (31%)
		Ig	614..679	CDD:319273	18/71 (25%)
		Ig_DSCAM	708..787	CDD:143211	23/78 (29%)
		Ig	805..898	CDD:325142	17/100 (17%)
		FN3	894..988	CDD:238020	24/100 (24%)
		FN3	995..1092	CDD:238020	27/111 (24%)
		fn3	1100..1186	CDD:306538	27/100 (27%)
		fn3	1199..1282	CDD:306538	20/87 (23%)
		Ig	1312..1377	CDD:319273
		fn3	1405..1471	CDD:306538
		FN3	1492..1563	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010