DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and chl1a

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_021325513.1	Gene:	chl1a / 566148	ZFINID:	ZDB-GENE-090313-201	Length:	1310	Species:	Danio rerio

Alignment Length:	1013	Identity:	256/1013 - (25%)
Similarity:	437/1013 - (43%)	Gaps:	108/1013 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 CLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTI--SGGNLIIYEPKQALD-QGAYHCVAE 449
            |.|.|.|.|::.|.:     |.:::   ||....:.|.  :.|...|...|..:. ||.|.|.|.
Zfish    55 CEAKGNPRPTFRWTK-----DGMDF---DPHKDPQVTTEENTGTFEIPNKKDKVKYQGKYRCYAS 111

  Fly   450 NKFGRIRSESAHLNFGFIMEFNLKRSAETSEMNWGKSIF--CDPPQHYPDVRYYWARDYFPNFVE 512
            ||.|...||.|......:.:|. |...|...:..|.|:.  |:|||..|..:.||..:.. ..:|
Zfish   112 NKLGTATSEEAEFIVPMVPKFP-KEKIEPIVVTEGDSVVLECNPPQGIPPWQLYWMTNDL-RHIE 174

  Fly   513 EDQRVFVSRDGALYFSFIETVD-RANYSC-----TVQTLVSDTGRNGPFFPLRVTP----NSNYQ 567
            :::||.:...|.||||.....| ..:|.|     .::|:|..     |...|:|.|    ..:..
Zfish   175 QNERVSMGLSGNLYFSNTLVSDSHDDYCCFASFFKIRTIVQK-----PRMVLKVKPVDAKQEDGD 234

  Fly   568 ALIFANTFPKVFPEAPVA------GDEIRLECMAFGYPIPSYNWTRQGLPLQRNAYTINYGRVLI 626
            |.|.....|.:...:..:      |:|:.|||:|.|.|.|...|.:....|.:.....|:|::|.
Zfish   235 AKIVQERKPSILVPSSHSTTFLKKGEELELECIAEGLPTPEVEWIKIWGDLPKRTQIKNFGKLLT 299

  Fly   627 IQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQF-TIPLKDMIKDYNSDVTFICEAFAIPDA 690
            |.|....|.|:|.|...|.....:....:.::..|.: ..|||..:....||:...|.|...|..
Zfish   300 IPNIREEDEGKYMCKAKNQHGEDVHHFQVEVEEPPSWQKEPLKSQLAWIGSDIHINCSATGKPQP 364

  Fly   691 NYTWYKNAERLD--PANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFSSAQLRVLS 753
            ..||.:|.:.||  |:..::   ::.|.::.:|  .:.||.|:|||.|.|:..:..::|.:.|::
Zfish   365 TITWKRNGKPLDDFPSTHHK---MLDDRIIILK--AEQKDTAVYQCEASNKHGSLLANANVLVMN 424

  Fly   754 MKP-SFKKHPLESEVYAVYNGNTTIV-CDPEAAPRPKFQWKK---DGQVIGSGGHRRILPSGTLT 813
            ..| ...::.||   ||...|.:.|: |:..::|.....|::   :|.|  .|....:|.:|:|.
Zfish   425 HPPLILTRNYLE---YATMLGKSVIMDCNVFSSPPATLNWRREDPEGSV--DGERYSLLKNGSLQ 484

  Fly   814 ISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAAFDELL 878
            |.....:|.|.|.|:|:|..||......:.:....|.:|.|....|.: ..:..|.|:...|..|
Zfish   485 IHKVEMEDMGQYKCLANNSEGTASITTELFIKDSTRIVEAPQDMKVIR-GSVAELECQVECDPSL 548

  Fly   879 --DIAYVWKHNG-EVLKNNHDGTGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSI 940
              ::.:||..:| .:|.|:.:   |...|...|.:.|.|..|.|:|.|:|::::::.::...:::
Zfish   549 RRELEFVWLKDGINILSNSSE---RYFTDEGILQIFNVSHSDQGNYTCIVRTSLDQDTASAYITV 610

  Fly   941 EGAPGAPGGVQVIQISKTKAIIEWVDGS-HNGRAIRYYNILGRTNWN-RTWVNVSTHVQAREVDR 1003
            ...|..|..:.:..:......:.||:.| ||.....:......::|. ..|         :::.|
Zfish   611 LDVPDPPVELLLSDLKDRSVKLHWVNTSDHNSPITEFIIQYEESHWEPEKW---------KDLLR 666

  Fly  1004 YTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLT 1068
            .:||:.:..:.|.....|:|.|.|||::|...||.||..|.|....|...|.|:...|.....:.
Zfish   667 VSSRKFSAPLALYCHINYQFRVIAVNEIGRSHPSMPSGRYKTPPCAPDRNPENIKIEGHLPHQMD 731

  Fly  1069 ITWDPLLPQEQHSHGIHYKVFWKLKGAIE-WASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAI 1132
            |:|:||||.|.:..|:.||:.::|.|..: |....:|:...:   |.:.|.   :..||||:||.
Zfish   732 ISWEPLLPVEHNGPGLEYKLSYRLLGVEDSWKEQMVKRHSFV---VRDTPT---FVPYEVKIQAF 790

  Fly  1133 NSVGKGPESEIAVIHSAED------------MPQVAPQKPIALAYNSTCFNVTWQPIDMSRENIR 1185
            |..|..|..::...:|.||            :|.|||....|...|||...|:|.|:..:  .:|
Zfish   791 NRHGWAPGPKVVTGYSGEDFDIWHCLEGDATVPLVAPDNVSAEVLNSTLLKVSWSPVPQT--TLR 853

  Fly  1186 GKLIGHRLKYWKTTH--------QEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGP 1242
            |.|.|:.:.||:|..        .|..|:....  .|:..::.||:|.:.|.:.|..:|..|.||
Zfish   854 GHLGGYTVNYWQTQSLLTSKKIPSERQSLTIPG--NRSHTMVPGLKPFSEYSLTVNVFNRRGNGP 916

  Fly  1243 ESERFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRIWE--SDQNMIT 1305
            .|......|.:..|:: |..:.........:.:||  ..|.:....:.||.::...  .::.:..
Zfish   917 SSSPISFTTPQGVPEQ-PHYLKATNFQKDAITLVW--APPHETNGHLTGYLLQYQTVVDNETLGE 978

  Fly  1306 ANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSNGGDG 1343
            .|:..:......:..:.:|....||...:.|.:..|.|
Zfish   979 LNSVNISGADTTQWVLRDLQEDNSYKFYLSACTQVGCG 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	23/74 (31%)
		I-set	362..462	CDD:254352	24/76 (32%)
		Ig	466..559	CDD:299845	26/100 (26%)
		IG_like	584..657	CDD:214653	21/78 (27%)
		IGc2	586..645	CDD:197706	20/58 (34%)
		Ig	667..751	CDD:299845	24/85 (28%)
		IG_like	676..751	CDD:214653	22/76 (29%)
		IG_like	765..844	CDD:214653	22/82 (27%)
		Ig	773..844	CDD:299845	20/74 (27%)
		I-set	851..940	CDD:254352	22/91 (24%)
		Ig	866..944	CDD:299845	19/80 (24%)
		FN3	944..1043	CDD:238020	24/100 (24%)
		FN3	1053..1146	CDD:238020	28/93 (30%)
		fn3	1156..1244	CDD:278470	28/95 (29%)
		fn3	1259..1346	CDD:278470	13/87 (15%)
chl1a	XP_021325513.1	Ig	54..125	CDD:325142	24/77 (31%)
		Ig	129..222	CDD:325142	26/99 (26%)
		Ig	262..331	CDD:325142	19/68 (28%)
		Ig	349..422	CDD:325142	22/77 (29%)
		IG	440..515	CDD:214652	20/76 (26%)
		I-set	520..610	CDD:333254	23/93 (25%)
		FN3	614..703	CDD:238020	22/97 (23%)
		fn3	717..797	CDD:306538	27/85 (32%)
		fn3	826..918	CDD:306538	28/95 (29%)
		FN3	930..1016	CDD:238020	13/88 (15%)
		FN3	1092..1172	CDD:238020
		Bravo_FIGEY	1209..1290	CDD:316405
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10817
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810