DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cont and robo4

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_689255.3	Gene:	robo4 / 560765	ZFINID:	ZDB-GENE-020809-1	Length:	1134	Species:	Danio rerio

Alignment Length:	752	Identity:	160/752 - (21%)
Similarity:	260/752 - (34%)	Gaps:	222/752 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   655 INIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDR--YIIQDNV 717
            ||:   |:......|::....|..|..|.|...|:....|.:|.:.||...::...  .::.|..
Zfish    68 INL---PRIVHHPSDVVVRVGSPATLSCRAEGNPEPTIQWLRNGQPLDTDKMDAQSQPIVLPDGS 129

  Fly   718 L----TIKFLEKDKDDAMYQCGAQNQLKTSFS-SAQLRVLSMKPSFKKHPLESEVYAVYNGNTTI 777
            |    .:...:....:|:|.|.|.|.:..:.| :|.|.:.:::..|:..|  |:|........||
Zfish   130 LFFFSVVPGRKGQSHEAVYACIAHNSIGNATSRNASLHIAALREDFRVQP--SDVEVAIGEMATI 192

  Fly   778 VCDPEAA-PRPKFQWKKDGQVIGSGGHRRILPSGTLTISPTSRDDEGIYTCIASNQAGTDESH-A 840
            .|.|... |.|...|:|||.:|.|.........|.|.|:|..::|.|:|:|||||..|..||. |
Zfish   193 NCSPPVGHPEPNVTWRKDGILINSSNEHYTELKGKLIIAPAQKNDSGVYSCIASNMIGVRESRAA 257

  Fly   841 RVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDW 905
            |:.||.:...:..|....|.......|. |||..|.:..|.  |......|.|     ||.:::.
Zfish   258 RLSVLAKPVLLRKPEDVSVQLGESAQFF-CEADGDPMPSIE--WSREQGPLPN-----GRYLINP 314

  Fly   906 NR-LTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSH 969
            :. |.:|..:.:|.|.|.|.|:       :|..||:..|               :.::|...|:
Zfish   315 DHSLQIHYVTAQDMGRYSCTVE-------NKLGVSVASA---------------QLLVEDAGGT- 356

  Fly   970 NGRAIRYYNILGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIG 1034
                                       :.|::.:..|..:..:.|:|..|
Zfish   357 ---------------------------RLRDLHKELSALRVSLENVTVMS--------------- 379

  Fly  1035 TPSAPSPI---YSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAI 1096
            |.|..|.:   ..::..:|:.           :....:.:..|||                 .:.
Zfish   380 TASNMSQVMWKLQSFGSQPHY-----------LEGFEVLYRSLLP-----------------ASS 416

  Fly  1097 EWASDEIKK---QDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQ 1158
            :|.:..:.:   ..|:|      ||...| :||.||:...|...|.||....:...|.:|..|||
Zfish   417 DWTAQRVPQPSLHTHVG------PLKRGY-KYEFKVRPYGSSLYGRESNTRHLRVPEIVPSAAPQ 474

  Fly  1159 K-PIAL-AYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWAL--- 1218
            . .|.: |..:...:::|:|......|  |.:.|:::  |....:|:        |:.||.:
Zfish   475 DVSITMPAERNDTVHLSWEPPPHDAHN--GIIQGYQV--WCVESEEQ--------TSFNWTVDSG 527

  Fly  1219 -----IVGLQPDTYYFVKVMAYNAAGEGPESE--------RFEERTYRK---------APQKPPS 1261
                 |..|.|...|:|.|.|.|.||.|.:|:        |.|...|:.         :..|.|.
Zfish   528 THSIEIFTLLPSRLYWVTVAAVNGAGVGVQSDPYKLLIESRLEATPYQTGILSMSHFVSVIKEPV 592

  Fly  1262 SV---------------------HVYGINPS--------------------------TVRVVWRY 1279
            .:                     |:...|||                          .:...||
Zfish   593 FIGSVGTLLWCVLMITAVFLYRRHIRPANPSGKSSGLYRLESEDLIIKHRMAAPDSPWISGGWR- 656

  Fly  1280 VSPSQDEEPVEGYKVRIWESDQNMITANNTIVPIGQK 1316
              |..:.||.:|    :|...|.......|.:||..|
Zfish   657 --PGSNSEPKQG----LWTPSQENSGLRRTTLPITVK 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845
		I-set	362..462	CDD:254352
		Ig	466..559	CDD:299845
		IG_like	584..657	CDD:214653	1/1 (100%)
		IGc2	586..645	CDD:197706
		Ig	667..751	CDD:299845	20/90 (22%)
		IG_like	676..751	CDD:214653	19/81 (23%)
		IG_like	765..844	CDD:214653	31/80 (39%)
		Ig	773..844	CDD:299845	29/72 (40%)
		I-set	851..940	CDD:254352	22/89 (25%)
		Ig	866..944	CDD:299845	21/78 (27%)
		FN3	944..1043	CDD:238020	10/101 (10%)
		FN3	1053..1146	CDD:238020	17/95 (18%)
		fn3	1156..1244	CDD:278470	26/97 (27%)
		fn3	1259..1346	CDD:278470	17/105 (16%)
robo4	XP_689255.3	Ig1_Robo	70..169	CDD:143317	21/101 (21%)
		I-set	71..168	CDD:254352	21/96 (22%)
		I-set	175..261	CDD:254352	33/87 (38%)
		Ig2_Robo	177..261	CDD:143201	32/85 (38%)
		I-set	265..350	CDD:254352	24/114 (21%)
		Ig	282..350	CDD:299845	22/97 (23%)
		FN3	373..448	CDD:214495	20/124 (16%)
		FN3	472..560	CDD:238020	27/99 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100