DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and cntn1b

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_001014814.1	Gene:	cntn1b / 541474	ZFINID:	ZDB-GENE-041210-236	Length:	1031	Species:	Danio rerio

Alignment Length:	1141	Identity:	312/1141 - (27%)
Similarity:	488/1141 - (42%)	Gaps:	189/1141 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 MFMPAYEIELNLFICESKVLYSSDNVNIKLDDKRPYHYGLDINDMERIPRGPYFVKQPNDTTFDV 375
            |..|...:.|:||.|   ....:..:..::.:.|       |.|.|....||.|.::|.||.:..
Zfish     1 MATPGPAMLLSLFSC---FFLLAAAIKPRIFEPR-------IFDKEATGFGPIFEEEPLDTVYAE 55

  Fly   376 NKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQ--DRYTISGGNLIIYEPKQA 438
            :...  |.::::|.....|.....|:        |...:|..:.|  :.:::.||||:|..|::.
Zfish    56 DSPE--NKISMNCRVRANPPAIIKWW--------LNNWQIKLMEQPDEHFSLVGGNLVITNPEKN 110

  Fly   439 LDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNL-KRSAETSEMNWGKSIFCDPPQHYPD-VRYY 501
            ...|.|.|||:|.:|.:.|:.|::.||::.:|.. :|.....:...|..:.|.||..||| |.:.
Zfish   111 KHAGKYVCVAKNVYGTVMSKEANVKFGYLNQFPTDEREPVNVKEGQGAVLLCTPPSRYPDEVMFR 175

  Fly   502 WARDYFPNFVEEDQRVFVSRD-GALYFSFIETVDRANYSCTVQTLVSDTGRNGPFFPLRVTPN-- 563
            |..:.||||:..|||.|||:. |.||.:.:|..|..||||.|.:  ...|::....|:.:.|.
Zfish   176 WIYNDFPNFIIPDQRRFVSQSTGNLYIAKVEPSDVGNYSCFVSS--PTIGKSVFSMPIALIPQIE 238

  Fly   564 ---SNYQALIFANTFPKVFPEAPVAGDEIRLECMAFGYPIPSYNWTRQGLPLQRNAYTINYGRVL 625
               ..|.|.|... |||.:   .:....|.|||.|.|.|:|...|.:....|..|......|.:|
Zfish   239 KEVKRYPADIRVK-FPKTY---ALVHQNITLECFALGNPLPHIRWRKLDADLPPNYEVSMNGALL 299

  Fly   626 IIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDA 690
            .:.|....|.|.|.|...|.:.......::.::..|::...:.|..||..|::|..|.|...|..
Zfish   300 HLINVQYEDEGSYECETLNVKGMDWYRQWLYVEGPPEWAEHINDTEKDVGSELTLRCVAVGKPIP 364

  Fly   691 NYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFSSAQLRVLSMK 755
            ...|.|            |.|......|....|..: |..||||.|:|:..|.:::|:|||:|..
Zfish   365 WIRWLK------------DGYSYGKGELKFSSLTFE-DSGMYQCIAENEWGTIYANAELRVVSCA 416

  Fly   756 PSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSGGHRRILPSGTLTISPTSRD 820
            |:|..:|::..:....||...|.|:|.|||:|:|.||:..:::.:.....|...|:|.|...::.
Zfish   417 PTFIYNPVKKILLGAENGRVVIECNPRAAPKPRFIWKRGSELLSNSSRIFIWDDGSLEILNATKS 481

  Fly   821 DEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVW- 884
            |||.|||.|.|..|...| ...:.:.|...|...|....:...|.|.|.|.|::|..||:.::|
Zfish   482 DEGSYTCYAENDRGKSNS-TGTLTITEATKITVGPSNSEAAVGDTIVLQCSASYDPSLDVTFIWT 545

  Fly   885 ------------KHNGEVLKNNHDGTGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTS 937
                        :|  ..|..:|:.:|.::       :.|..:|.||.|.|..::.|:..:::..
Zfish   546 VDSYSINFYTDFEH--YELDMDHENSGDLL-------IKNIQIRHAGHYICTAQTIVDNATAEAD 601

  Fly   938 VSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAI-------RYYNILGRTNWNR-----TWV 990
            |.:.|.||.||||:|.:|..|...|.|..||.:|..:       |.:..|...:|..     .::
Zfish   602 VFVRGLPGPPGGVRVEEIGDTSVKIRWCLGSDHGSPLIQHIVQTRDFYALDPEDWKTATTTPAFL 666

  Fly   991 NVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPR 1055
            |.||             :.|.||:|.||..|||.|.|:|:.|.|..|.||....|::.:|.:||.
Zfish   667 NGST-------------ESATVVDLYPWMQYEFRVHAINEFGAGENSRPSIKIKTWDARPTVAPS 718

  Fly  1056 NVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIPLNN 1120
            :|.|..|..|:|.:||:|:.||........|.|.:|.....||.           .:.|..|...
Zfish   719 DVIGQVGISGELIVTWNPVKPQFFFGKKFGYVVAFKQHEDYEWK-----------WSTVEDPETR 772

  Fly  1121 YY---------TEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQP 1176
            .|         ||.::||...|:.|:||.|.|:|::|....|..||....|....||...|.|.|
Zfish   773 RYVYKESMTPDTEIQIKVSTFNNKGEGPASLISVVYSPRIAPTEAPLDVYARQVTSTEALVWWLP 837

  Fly  1177 --------IDMSRENIRGKLIGHRLKYWKTTHQEEDSVYYLSRT----TRNWALIVGLQPDTYYF 1229
                    :|           |::::||:   :.:|:....||.    |.|...:..::||::|.
Zfish   838 VYQAPPMWVD-----------GYQIRYWR---KYDDNEAAASRVIVHRTVNQTRLENMRPDSHYL 888

  Fly  1230 VKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVY---GINPSTVRVVWRYVSPSQDEEPVEG 1291
            ::|.|:|.||.||.||..|..|.|..|.:   .:.||   ......:.:.|.::....:|..|||
Zfish   889 IEVRAFNGAGLGPPSEHCEMFTRRPPPSR---RLRVYKYVSFTRKWLYLYWDHIYNYWNESYVEG 950

  Fly  1292 YKVRIWESDQNMITANNTIVPIGQKLESYINNLTPGK-----------SYNMRVLAYSNGGDGRM 1345
            ||:...:..                 |.|....|.|:           .|.:.:.|...||||.:
Zfish   951 YKILFRKEG-----------------ERYGKLYTTGRHYIDFPMPETGDYVIELRARCEGGDGPI 998

  Fly  1346 SSPTLHFQMGKTTRNGANTRHGHNINTALILSTLLL 1381
            |...:   .||.         ...:.:..::|.|||
Zfish   999 SQIRV---QGKA---------AVGVESVSVVSVLLL 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	27/100 (27%)
		I-set	362..462	CDD:254352	27/101 (27%)
		Ig	466..559	CDD:299845	33/95 (35%)
		IG_like	584..657	CDD:214653	19/72 (26%)
		IGc2	586..645	CDD:197706	18/58 (31%)
		Ig	667..751	CDD:299845	24/83 (29%)
		IG_like	676..751	CDD:214653	21/74 (28%)
		IG_like	765..844	CDD:214653	26/78 (33%)
		Ig	773..844	CDD:299845	25/70 (36%)
		I-set	851..940	CDD:254352	23/101 (23%)
		Ig	866..944	CDD:299845	21/90 (23%)
		FN3	944..1043	CDD:238020	37/110 (34%)
		FN3	1053..1146	CDD:238020	30/101 (30%)
		fn3	1156..1244	CDD:278470	27/99 (27%)
		fn3	1259..1346	CDD:278470	19/100 (19%)
cntn1b	NP_001014814.1	Ig	41..133	CDD:299845	27/101 (27%)
		I-set	42..135	CDD:254352	27/102 (26%)
		Ig	138..234	CDD:299845	33/97 (34%)
		IG_like	148..219	CDD:214653	29/70 (41%)
		Ig	245..332	CDD:299845	24/90 (27%)
		IG_like	253..331	CDD:214653	21/80 (26%)
		Ig	336..412	CDD:299845	24/88 (27%)
		IG_like	343..412	CDD:214653	24/81 (30%)
		IG_like	428..505	CDD:214653	26/77 (34%)
		Ig5_Contactin_like	434..505	CDD:143170	25/71 (35%)
		IG_like	515..604	CDD:214653	22/97 (23%)
		Ig	524..608	CDD:299845	22/92 (24%)
		FN3	608..708	CDD:238020	37/112 (33%)
		FN3	716..808	CDD:238020	31/102 (30%)
		fn3	817..903	CDD:278470	27/99 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9761
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1476
OMA	1	1.010	-	-		QHG46028
OrthoDB	1	1.010	-	-		D292460at33208
OrthoFinder	1	1.000	-	-		FOG0000550
OrthoInspector	1	1.000	-	-		otm24534
orthoMCL	1	0.900	-	-		OOG6_100978
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.880