DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cont and CNTN3

DIOPT Version :9

Sequence 1:NP_649461.2 Gene:Cont / 40553 FlyBaseID:FBgn0037240 Length:1390 Species:Drosophila melanogaster
Sequence 2:NP_001380305.1 Gene:CNTN3 / 5067 HGNCID:2173 Length:1028 Species:Homo sapiens


Alignment Length:1017 Identity:331/1017 - (32%)
Similarity:481/1017 - (47%) Gaps:76/1017 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   356 ERIPRGPYFVKQPNDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQ 420
            |.:.:||.|:|:|:::.|.|....  ..:||.|.|.|.|:|.|.|        :|....||...:
Human    20 ELLLQGPVFIKEPSNSIFPVGSED--KKITLHCEARGNPSPHYRW--------QLNGSDIDMSME 74

  Fly   421 DRYTISGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFNLK-RSAETSEMNWG 484
            .||.::||||::..|.:..|.|.|.|.|.|..|.|.|..|.|.|.::..|..| ||..:.....|
Human    75 HRYKLNGGNLVVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQG 139

  Fly   485 KSIFCDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRD-GALYFSFIETVDRANYSCTVQTLVSD 548
            ..:.|.||.|..::.|.|..:.:|:|||||.|.|||:: |.||.|.:|..|..||:|.|.::|::
Human   140 VVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTN 204

  Fly   549 TGRNGPFFPLRVTPNSNYQALIFANTFPKV---FPEA-PVA-GDEIRLECMAFGYPIPSYNWTR- 607
            ....|...||.:..:.     :.....||:   |||. |.| |..::|||.|.|.|||..||.| 
Human   205 ARVLGSPTPLVLRSDG-----VMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRS 264

  Fly   608 QGLPLQRNAYTINYGRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIK 672
            .|||.........:..||.|.|....|.|.|.|...|.|...:....:....:|.:...:||:..
Human   265 DGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEI 329

  Fly   673 DYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAMYQCGAQ 737
            .....:.:.|.|...|..:|.|.||...|    :..:|..|::..|||..|.. .|..|:||.|:
Human   330 AVEDSLYWECRASGKPKPSYRWLKNGAAL----VLEERTQIENGALTISNLSV-TDSGMFQCIAE 389

  Fly   738 NQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGSGG 802
            |:....:|||:|:|::..|.|.|:|::..|........::.|.|.|:||....|||..  :....
Human   390 NKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGD--VSVQE 452

  Fly   803 HRRI--LPSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDL 865
            |.||  |..|.|.|:..::.|.|.|||:|.||.|.......::|.:..|....|....||....:
Human   453 HERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESV 517

  Fly   866 IFLHCEAAFDELLDIAYVWKHNGEVLKNNHDGT------GRIIVDWNRLTVHNTSMRDAGDYECV 924
            | |.|:...|.||||.:.|..||.:.....||:      |....|   |.:.|..::.:|.|.|:
Human   518 I-LPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGD---LMIRNIQLKHSGKYVCM 578

  Fly   925 VKSAVNEISSKTSVSIEGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTNWNRTW 989
            |::.|:.:||...:.:.|:||.|..|:|.:|:.|.|.:.|.:|..|...:..|:|..||.::..|
Human   579 VQTGVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGW 643

  Fly   990 VNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAP 1054
            ..|:|..:..:...:|    |.||.|.||..|||.|.|.|.:|.|.||.||....|.|..|.:.|
Human   644 QTVTTVPEVIDGKTHT----ATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPP 704

  Fly  1055 RNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVN---I 1116
            ..|.||||...:|.|||||:..:.|:..|..|.|.::..|...|....:...|.......|   :
Human   705 SEVNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIV 769

  Fly  1117 PLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSR 1181
            |    |:.|||||...|:.|:||.|.:..:.|||:.|.|||.:..|.:.:|:...|:|..|....
Human   770 P----YSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKL 830

  Fly  1182 ENIRGKLIGHRLKYWKTTHQEEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESER 1246
            .|  |.|:|:.::||....:||.|...........|.:.||:.:..|:..|.|||:||.||.|..
Human   831 SN--GHLLGYEVRYWNGGGKEESSSKMKVAGNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSAT 893

  Fly  1247 FEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRIWESDQNMITANNT-- 1309
            ....|.:..|.:||.:| |:....:.|.:.|..|...::|..|.||||....|.||.:...||  
Human   894 VNVTTKKTPPSQPPGNV-VWNATDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQNNVQVLNTNK 957

  Fly  1310 -----IVPIGQKLESYINNLTPGKSYNMRVLAYSNGGDGRMS 1346
                 ::||   .|.||          :.|.|.::||||..|
Human   958 TSAELVLPI---KEDYI----------IEVKATTDGGDGTSS 986

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ContNP_649461.2 CLECT 139..>223 CDD:214480
Ig 361..460 CDD:299845 35/98 (36%)
I-set 362..462 CDD:254352 35/99 (35%)
Ig 466..559 CDD:299845 34/94 (36%)
IG_like 584..657 CDD:214653 26/74 (35%)
IGc2 586..645 CDD:197706 23/59 (39%)
Ig 667..751 CDD:299845 26/83 (31%)
IG_like 676..751 CDD:214653 24/74 (32%)
IG_like 765..844 CDD:214653 25/80 (31%)
Ig 773..844 CDD:299845 24/72 (33%)
I-set 851..940 CDD:254352 27/94 (29%)
Ig 866..944 CDD:299845 25/83 (30%)
FN3 944..1043 CDD:238020 37/98 (38%)
FN3 1053..1146 CDD:238020 32/95 (34%)
fn3 1156..1244 CDD:278470 28/87 (32%)
fn3 1259..1346 CDD:278470 29/93 (31%)
CNTN3NP_001380305.1 Ig 25..120 CDD:416386 38/104 (37%)
Ig strand A 27..31 CDD:409353 1/3 (33%)
Ig strand A' 34..39 CDD:409353 1/4 (25%)
Ig strand B 45..53 CDD:409353 3/7 (43%)
Ig strand C 58..64 CDD:409353 3/13 (23%)
Ig strand C' 66..69 CDD:409353 0/2 (0%)
Ig strand D 76..80 CDD:409353 2/3 (67%)
Ig strand E 82..88 CDD:409353 3/5 (60%)
Ig strand F 95..104 CDD:409353 4/8 (50%)
Ig strand G 107..120 CDD:409353 6/12 (50%)
Ig 129..214 CDD:416386 31/84 (37%)
Ig strand A 130..135 CDD:409353 1/4 (25%)
Ig strand B 139..145 CDD:409353 1/5 (20%)
Ig strand C 153..159 CDD:409353 2/5 (40%)
Ig strand C' 164..166 CDD:409353 0/1 (0%)
Ig strand D 171..176 CDD:409353 3/4 (75%)
Ig strand E 179..183 CDD:409353 2/3 (67%)
Ig strand F 193..201 CDD:409353 4/7 (57%)
Ig strand G 203..214 CDD:409353 1/10 (10%)
Ig 227..315 CDD:416386 32/87 (37%)
Ig strand A 227..232 CDD:409353 2/4 (50%)
Ig strand A' 235..240 CDD:409353 2/4 (50%)
Ig strand B 243..252 CDD:409353 3/8 (38%)
Ig strand C 258..262 CDD:409353 1/3 (33%)
Ig strand C' 265..267 CDD:409353 0/1 (0%)
Ig strand D 276..279 CDD:409353 0/2 (0%)
Ig strand E 280..285 CDD:409353 2/4 (50%)
Ig strand F 293..301 CDD:409353 3/7 (43%)
Ig strand G 304..315 CDD:409353 0/10 (0%)
Ig 320..403 CDD:416386 26/87 (30%)
Ig strand A' 326..330 CDD:409353 1/3 (33%)
Ig strand B 334..342 CDD:409353 1/7 (14%)
Ig strand C 348..353 CDD:409353 2/4 (50%)
Ig strand C' 355..358 CDD:409353 0/2 (0%)
Ig strand D 363..367 CDD:409353 1/3 (33%)
Ig strand E 369..374 CDD:409353 2/4 (50%)
Ig strand F 383..390 CDD:409353 4/6 (67%)
Ig strand G 394..403 CDD:409353 4/8 (50%)
Ig 408..496 CDD:416386 29/89 (33%)
Ig strand A 408..413 CDD:409353 2/4 (50%)
Ig strand A' 416..421 CDD:409353 1/4 (25%)
Ig strand B 425..432 CDD:409353 0/6 (0%)
Ig strand C 440..444 CDD:409353 0/3 (0%)
Ig strand D 458..461 CDD:409353 1/2 (50%)
Ig strand E 462..467 CDD:409353 2/4 (50%)
Ig strand F 475..483 CDD:409353 5/7 (71%)
Ig strand G 489..496 CDD:409353 0/6 (0%)
Ig 498..598 CDD:416386 29/103 (28%)
Ig strand A 498..504 CDD:409353 1/5 (20%)
Ig strand A' 507..512 CDD:409353 0/4 (0%)
Ig strand B 515..523 CDD:409353 3/8 (38%)
Ig strand C 532..536 CDD:409353 0/3 (0%)
Ig strand E 560..564 CDD:409353 2/6 (33%)
Ig strand F 573..580 CDD:409353 3/6 (50%)
Ig strand G 587..591 CDD:409353 2/3 (67%)
FN3 598..695 CDD:238020 37/100 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 684..713 13/28 (46%)
FN3 703..795 CDD:238020 32/95 (34%)
FN3 805..898 CDD:238020 29/94 (31%)
FN3 906..991 CDD:238020 30/95 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 72 1.000 Domainoid score I9318
eggNOG 1 0.900 - - E1_KOG3513
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7461
Inparanoid 1 1.050 493 1.000 Inparanoid score I1415
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46028
OrthoDB 1 1.010 - - D292460at33208
OrthoFinder 1 1.000 - - FOG0000550
OrthoInspector 1 1.000 - - otm41700
orthoMCL 1 0.900 - - OOG6_100978
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X342
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.740

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