DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and NRCAM

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_011514555.1	Gene:	NRCAM / 4897	HGNCID:	7994	Length:	1311	Species:	Homo sapiens

Alignment Length:	1143	Identity:	291/1143 - (25%)
Similarity:	462/1143 - (40%)	Gaps:	218/1143 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 KKRDRWMFMPAYEIELNLFICESKVLYSSDNVNIKLDDKRPYHYGLDINDMERIPRGPYFVKQ-P 368
            |||     :.|..:.|.||:|:   :.|:  :.:.||.|.          :|.:.:.|...:| |
Human     9 KKR-----LSAGRVPLILFLCQ---MISA--LEVPLDPKL----------LEDLVQPPTITQQSP 53

  Fly   369 NDTTFDVNKNRLINDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTISGGNLII- 432
            .|...|..:|     :.:.|.|.|.|.||::|.|.   ....:..| |||...:  ...|.|||
Human    54 KDYIIDPREN-----IVIQCEAKGKPPPSFSWTRN---GTHFDIDK-DPLVTMK--PGTGTLIIN 107

  Fly   433 --YEPKQALDQGAYHCVAENKFGR-------IRSESAHLNFGFIMEFNLKRSAETSEMNWGKSIF 488
              .|.|....:|.|.|.|.|:.|.       :|...:.|        ..|...|...:..|:|:.
Human   108 IMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPL--------WTKEKLEPITLQSGQSLV 164

  Fly   489 --CDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRDGALYFSFIETVD-RANYSC---------- 540
              |.||...|....:|..:.|.. :.:.:||....:|.||||.:...| |.:|.|
Human   165 LPCRPPIGLPPPIIFWMDNSFQR-LPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTI 228

  Fly   541 ------------------TVQTLVSDT-------GRNGPFFPLRVTPNSNYQALIFANTFPKVFP 580
                              |:...:|||       .|..|  |..:||..|            ...
Human   229 QQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERP--PTFLTPEGN------------ASN 279

  Fly   581 EAPVAGDEIRLECMAFGYPIPSYNWTRQG--LPLQRNAYTINYGRVLIIQNATTNDNGEYSCTIT 643
            :..:.|:.:.|||:|.|.|.|...|.::.  ||..|..|. |:.:.|.|.:.:..|:|.|.|...
Human   280 KEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYK-NFEKTLQIIHVSEADSGNYQCIAK 343

  Fly   644 NPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPANINR 708
            |....:..:|.:.::..|.:....::::.....|.|.||.|...|....:|..|...::.|..:.
Human   344 NALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDP 408

  Fly   709 DRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNG 773
            .|.|..|.::....  :::..|:|||.|.|:.....::|.:.||:..|.... |..:....:.|.
Human   409 SRKIDGDTIIFSNV--QERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILT-PANTLYQVIANR 470

  Fly   774 NTTIVCDPEAAPRPKFQWKKDGQVIGSGGHRRIL---PSGTLTISPTSRDDEGIYTCIASNQAG- 834
            ...:.|....:|.|..:|.|..:  ||..|..|.   .:|||.|....:|..|.|||:|.|:.|
Human   471 PALLDCAFFGSPLPTIEWFKGAK--GSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGM 533

  Fly   835 -TDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNNHD-- 896
             .:|.|   :.:::..:|...|:..|.:...::...|:...|..|.:..:|      ||:|.:
Human   534 AKNEVH---LEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLW------LKDNRELP 589

  Fly   897 GTGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVI-------- 953
            ...|..||.:.|.|.:.|..|:|.|.||..:.::.:|:...:|:......|..|..:
Human   590 SDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLE 654

  Fly   954 ---QISKTKAIIEWVDGSHNGRAIRYYNILGRTNWNR--TWVNVSTHVQAREVDRYTSRQQAEVV 1013
               |:.|: ..:.|..|..|...|..:.|......::  .|     |.|.......|:.|    :
Human   655 LTDQLDKS-VQLSWTPGDDNNSPITKFIIEYEDAMHKPGLW-----HHQTEVSGTQTTAQ----L 709

  Fly  1014 NLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQE 1078
            .|:|:..|.|.|.|||.:|...||..|..|.|...:|...|..|.|.|.:..:|.|||.||...|
Human   710 KLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFE 774

  Fly  1079 QHSHGIHYKVFWKLK-GAIEWASDEIKKQDHMGVAVVNIPLNNY-------YTEYEVKVQAINSV 1135
            .:..|:.|||.|:.| |..||.|          |.|.|:  :.|       :..|.:||||:|.:
Human   775 SNGPGLQYKVSWRQKDGDDEWTS----------VVVANV--SKYIVSGTPTFVPYLIKVQALNDM 827

  Fly  1136 GKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWKTTH 1200
            |..||..:.:.||.||:|.|||........|||...|.|.|:.:  ::|||.|.|:|:.||||..
Human   828 GFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPL--KSIRGHLQGYRIYYWKTQS 890

  Fly  1201 QEEDSVYYLSRT------TRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQKP 1259
            ..:.:..::.:.      ::...::.||:|.::|.:.|...|..||||.|   .:|.: ..|:..
Human   891 SSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPAS---PDRVF-NTPEGV 951

  Fly  1260 PSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKVRIWE--SDQNMITANNTI--VPI------- 1313
            ||:       ||::::    |:|:.|...:|      |:  |..|.|....|:  .||
Human   952 PSA-------PSSLKI----VNPTLDSLTLE------WDPPSHPNGILTEYTLKYQPINSTHELG 999

  Fly  1314 --------GQKLESYINNLTPGKSYNMRVLAYSNGGDG 1343
                    ..|....:.||.....|.....|.::.|.|
Human  1000 PLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSG 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	31/109 (28%)
		I-set	362..462	CDD:254352	31/110 (28%)
		Ig	466..559	CDD:299845	28/130 (22%)
		IG_like	584..657	CDD:214653	22/74 (30%)
		IGc2	586..645	CDD:197706	20/60 (33%)
		Ig	667..751	CDD:299845	19/83 (23%)
		IG_like	676..751	CDD:214653	19/74 (26%)
		IG_like	765..844	CDD:214653	24/83 (29%)
		Ig	773..844	CDD:299845	23/75 (31%)
		I-set	851..940	CDD:254352	22/90 (24%)
		Ig	866..944	CDD:299845	20/79 (25%)
		FN3	944..1043	CDD:238020	26/111 (23%)
		FN3	1053..1146	CDD:238020	34/100 (34%)
		fn3	1156..1244	CDD:278470	28/93 (30%)
		fn3	1259..1346	CDD:278470	22/104 (21%)
NRCAM	XP_011514555.1	IG_like	53..139	CDD:214653	28/96 (29%)
		Ig6_NrCAM	64..140	CDD:143282	24/81 (30%)
		Ig	145..237	CDD:299845	22/100 (22%)
		IG_like	153..238	CDD:214653	20/85 (24%)
		I-set	268..357	CDD:254352	26/101 (26%)
		Ig	288..358	CDD:299845	21/70 (30%)
		I-set	361..449	CDD:254352	20/89 (22%)
		Ig4_NrCAM	375..450	CDD:143276	19/76 (25%)
		I-set	454..542	CDD:254352	26/93 (28%)
		IGc2	469..532	CDD:197706	21/64 (33%)
		I-set	548..633	CDD:254352	22/90 (24%)
		Ig	566..636	CDD:299845	20/75 (27%)
		FN3	647..737	CDD:238020	23/99 (23%)
		fn3	750..832	CDD:278470	32/93 (34%)
		fn3	848..940	CDD:278470	28/93 (30%)
		FN3	952..1047	CDD:238020	22/103 (21%)
		fn3	1070..1147	CDD:278470
		Bravo_FIGEY	1194..1287	CDD:290593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810