DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and Dscam3

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster

Alignment Length:	1194	Identity:	259/1194 - (21%)
Similarity:	450/1194 - (37%)	Gaps:	278/1194 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 NDVTLSCLANGYPTPSYTWYREVYVDDRLEYQKIDPLAQDRYTISGGNLIIYEPKQALDQGAYHC 446
            |||.|.|...|.|.|.:||||   |.|.   ..:.|:...:..|....|::.:.....|.|.:.|
  Fly   262 NDVHLPCNIQGNPFPIFTWYR---VSDS---AALYPIPSSQRVILSRTLLLIKNADERDAGKWIC 320

  Fly   447 VAENKFGRIRSE-----SAHLNFGFIMEFNLKRSAETSEMNWGKSIFCDPPQHYPDVRYYWARDY 506
            .|.|:||..|.|     :::::...:.:..:..|..|:..|      |.......|. ..|..:.
  Fly   321 QASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFN------CTTTGSAIDA-IDWLHNG 378

  Fly   507 FPNFVEEDQRVFVSRDGALYFS----FIETV---DRANYSCTVQTLVSDTGRNGPFFPLRVTPNS 564
            .|  ::.:..:...||...:.|    .::.|   ||..|.|.|:                 ...:
  Fly   379 KP--LQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVE-----------------NQRA 424

  Fly   565 NYQA---LIFANTFPKV---FPEAPV-AGDEIRLECMAFGYPIPSYNWTRQGLPLQ----RNAYT 618
            :.||   |...:|.|::   |.|..| .|..|.|:|.|.|.|.|.:.|.....|:.    .:.:.
  Fly   425 SAQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFA 489

  Fly   619 INY-----GRV---LIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTI--PLKDMIKD 673
            |..     |.|   |.|.:...:|.|.|.|..:|...::..|..:|:...|....  |:|.:.
  Fly   490 IGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPIKAVA-- 552

  Fly   674 YNSDVTFICEAFAIPDANYTWYKNAERLDPANINRDRYIIQDNVLTIKFLEKDKDDAMYQC---- 734
             ..|:...|.....|.....|.|..:.|..:|......:.....|.||.:|..:|..:|.|
  Fly   553 -GEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRS 616

  Fly   735 -------------------------------GAQNQLKTSFSS---------------------- 746
                                           |.:.|:..:.||
  Fly   617 RAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQI 681

  Fly   747 --------------------------------------AQLRVLSMKPSFKKHPLESEVYAVYNG 773
                                                  |:|:| .:.|.::..|:::   |:..|
  Fly   682 TEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQV-RVAPRWRYEPMDT---AIMLG 742

  Fly   774 NT-TIVCDPEAAPRPKFQWKKDGQVIGSGGHRRI-LPSGTLTISPTSRDDEGIYTCIASNQAGTD 836
            || :|.|:.|..|.|...|.| ||..||...:.: :.:.:|.::..:.:|||.|.|.|:|:.|..
  Fly   743 NTISINCEAEGYPIPTITWFK-GQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAG 806

  Fly   837 -ESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNN------ 894
             :...|:.|.:..|| |...:.|.|:.:|.:.|.|.|..||.:.|.:. ::||.:..||
  Fly   807 LKKTIRINVNEPARF-EQSARNISSRRNDPVTLDCHAKGDEPITIGWT-QNNGRIDLNNFRFSIA 869

  Fly   895 ----HDGTGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQI 955
                ..|     || ::||:.::...|:|.|.|:.::..........::::..|..|..:::.::
  Fly   870 EMKTEKG-----VD-SQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEV 928

  Fly   956 SKTKAIIEW---VDGSH-------NGRAIRYYNILGRT-----NWNRTWVNVSTHVQAREVDR-Y 1004
            ......:.|   .||:.       ..:|::|....|..     :||...:|||  :.:..:.| |
  Fly   929 GSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVS--LPSTSISRSY 991

  Fly  1005 TS--RQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDL 1067
            .|  |:.|.|..|||.:.:...:.|:|::. .:....:.:..|.|:.|..||.||....|...:|
  Fly   992 DSDLRESAIVAGLTPATTFLIRMQAINEIE-RSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESEL 1055

  Fly  1068 TITWDPLLPQEQHSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIPLNN------------ 1120
            .:||.  :|..:..:|       :|.|.....|:|  ||:...::|||..|.:
  Fly  1056 IVTWQ--IPPRESWNG-------ELIGYTVNCSEE--KQNINFISVVNSSLKSTIVSGWATTKAT 1109

  Fly  1121 -----YYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTCFNVTW--QPID 1178
                 .|:.|.|.::|:||.|.||.|......:||.:|:.|||.....|.:|....::|  .|:
  Fly  1110 LRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPL- 1173

  Fly  1179 MSRENIRGKLI-GHRLKYWKTTHQ-EEDSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEG 1241
                ...|.:| |:::.|....|| :..:...:.||:.....:..|...:.|.::|:||.|.|:|
  Fly  1174 ----QFHGGIIQGYKILYRPIVHQIDFPAKLEIKRTSNLETYLHTLHKASNYSIRVLAYTATGDG 1234

  Fly  1242 PESERFEERTYRKAPQKPPSSVHVYGINPSTVRVVWRYVSPSQDEEPVEGYKV------RIWESD 1300
            ..|.....:|....|. .|:::....:...::.:.|  ::|......:..|.|      |..::.
  Fly  1235 LASHPLFCQTDDDVPD-APAAIKAAALTADSILISW--LTPKNRNGIISHYTVYSREAGRKGQAK 1296

  Fly  1301 QNMITANNTIVPIGQKLESYINNLTPGKSYNMRVLAYSNGGDGRMSS----------PTLHFQMG 1355
            .:|:..:....|:  ..||  .:|...:.|...|.|.::.|:|..:|          |......|
  Fly  1297 THMVRVDENGYPV--TFES--RSLAENQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIASFG 1357

  Fly  1356 KTTRNGANTRHGHNINTALILSTL 1379
            :..|..        :.|.|:|..|
  Fly  1358 QVVRKA--------VGTGLVLECL 1373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	26/82 (32%)
		I-set	362..462	CDD:254352	26/84 (31%)
		Ig	466..559	CDD:299845	16/99 (16%)
		IG_like	584..657	CDD:214653	22/85 (26%)
		IGc2	586..645	CDD:197706	19/70 (27%)
		Ig	667..751	CDD:299845	21/178 (12%)
		IG_like	676..751	CDD:214653	20/169 (12%)
		IG_like	765..844	CDD:214653	25/81 (31%)
		Ig	773..844	CDD:299845	24/73 (33%)
		I-set	851..940	CDD:254352	23/98 (23%)
		Ig	866..944	CDD:299845	19/87 (22%)
		FN3	944..1043	CDD:238020	24/116 (21%)
		FN3	1053..1146	CDD:238020	30/109 (28%)
		fn3	1156..1244	CDD:278470	23/91 (25%)
		fn3	1259..1346	CDD:278470	16/92 (17%)
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	26/80 (33%)
		Ig	264..334	CDD:143165	24/75 (32%)
		I-set	345..433	CDD:254352	18/113 (16%)
		Ig	358..431	CDD:143165	16/98 (16%)
		Ig	456..533	CDD:143165	20/76 (26%)
		IGc2	553..619	CDD:197706	14/65 (22%)
		I-set	634..724	CDD:254352	6/89 (7%)
		ig	645..712	CDD:278476	4/66 (6%)
		IG_like	734..815	CDD:214653	26/84 (31%)
		Ig	745..815	CDD:299845	21/70 (30%)
		I-set	820..913	CDD:254352	25/100 (25%)
		Ig	838..920	CDD:299845	20/88 (23%)
		FN3	917..1033	CDD:238020	24/118 (20%)
		FN3	1040..1142	CDD:238020	30/112 (27%)
		fn3	1150..1237	CDD:278470	23/91 (25%)
		FN3	1263..1345	CDD:238020	16/87 (18%)
		Ig	1350..1436	CDD:299845	7/32 (22%)
		IG_like	1358..1436	CDD:214653	5/24 (21%)
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452256
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840