DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cont and L1CAM

DIOPT Version :9

Sequence 1:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_000416.1	Gene:	L1CAM / 3897	HGNCID:	6470	Length:	1257	Species:	Homo sapiens

Alignment Length:	1095	Identity:	268/1095 - (24%)
Similarity:	464/1095 - (42%)	Gaps:	190/1095 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 RIP---RGPYFVKQPNDTTFDVNKNRLI----NDVTLSCLANGYPTPSYTWYREVYVDDRLEYQK 414
            :||   .|.:.::.|..|  :.:..||:    :|::|.|.|:|.|...:.|.|     |.:.::.
Human    21 QIPEEYEGHHVMEPPVIT--EQSPRRLVVFPTDDISLKCEASGKPEVQFRWTR-----DGVHFKP 78

  Fly   415 IDPLA--------QDRYTISGGNLIIYEPKQALDQGAYHCVAENKFGRIRSESAHLNFGFIMEFN 471
            .:.|.        ...:||:|.|....:    ..||.|.|.|.||.|...|....|    :.|..
Human    79 KEELGVTVYQSPHSGSFTITGNNSNFAQ----RFQGIYRCFASNKLGTAMSHEIRL----MAEGA 135

  Fly   472 LKRSAET---SEMNWGKSIF--CDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSRDGALYFSFIE 531
            .|...||   .|:..|:|:.  |:||.....:|.||......: :::|:||.:.::|.|||:.:.
Human   136 PKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILH-IKQDERVTMGQNGNLYFANVL 199

  Fly   532 TVD-RANYSC-----TVQTLVSDTGRNGPFFPLRVTPNSNYQALIFANTFPK-VFPE------AP 583
            |.| .::|.|     ..:|::    :..| ..|||...::     ..:..|: :||.      ..
Human   200 TSDNHSDYICHAHFPGTRTII----QKEP-IDLRVKATNS-----MIDRKPRLLFPTNSSSHLVA 254

  Fly   584 VAGDEIRLECMAFGYPIPSYNWTRQGLPLQRNAYTI-NYGRVLIIQNATTNDNGEYSCTITNPRK 647
            :.|..:.|||:|.|:|.|:..|.|...|:..:..|. |:.:.|.:......|:|||.|...|...
Human   255 LQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLG 319

  Fly   648 TLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYTWYKNAERLDPANINRD-RY 711
            :...:.|:.::..|.:....:..:..........|:....|....||..|.  :....:.:| :|
Human   320 SARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING--IPVEELAKDQKY 382

  Fly   712 IIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFSSAQLRVLSMKPSFKKHPLESEVYAVYNGNTT 776
            .||...|.:..:: ..|..:.||.|:|:.....::|.:.|:.: |: |....:::.|....|:|.
Human   383 RIQRGALILSNVQ-PSDTMVTQCEARNRHGLLLANAYIYVVQL-PA-KILTADNQTYMAVQGSTA 444

  Fly   777 -IVCDPEAAPRPKFQW-KKDGQVIGSGGHRRILP--SGTLTISPTSRDDEGIYTCIASNQAGTDE 837
             ::|....||.|..|| .:||..:..  ..|..|  :|||.|.....:|.|.|.|:|:|    |:
Human   445 YLLCKAFGAPVPSVQWLDEDGTTVLQ--DERFFPYANGTLGIRDLQANDTGRYFCLAAN----DQ 503

  Fly   838 SHARVIV---LQEIRFIETPPQRIVSKEHDLIFLHCEAAFDELLDIAYVWKHNGEVLKNNHDGTG 899
            ::..::.   :::...|...|:..:.|:...:...|:|:||..|..:..|:.:|..|:...|...
Human   504 NNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDK 568

  Fly   900 RIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGAPGAPGGVQVIQ----ISKTKA 960
            ..|.| .||.:|:....|.|:|.||..:.::.:.|:..:.:.|:|| |....|:.    :::::.
Human   569 YFIED-GRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPG-PVPRLVLSDLHLLTQSQV 631

  Fly   961 IIEWVDGSHNGRAIRYYNI------LGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWS 1019
            .:.|.....:...|..|:|      :....|             ..:.:....|.:..:.|:|:.
Human   632 RVSWSPAEDHNAPIEKYDIEFEDKEMAPEKW-------------YSLGKVPGNQTSTTLKLSPYV 683

  Fly  1020 AYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGI 1084
            .|.|.|||:|..|.|.||..|....|.|..|...|.:|.|.|.:..::.|||.||...:.::..:
Human   684 HYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQV 748

  Fly  1085 HYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSA 1149
            .|:|.|:.:|......::|.....:.|:..:.     :..||:||||:||.|||||.::.:.:|.
Human   749 QYRVQWRPQGTRGPWQEQIVSDPFLVVSNTST-----FVPYEIKVQAVNSQGKGPEPQVTIGYSG 808

  Fly  1150 EDMPQVAPQKPIALAYNSTCFNVTWQPIDMSRENIRGKLIGHRLKYWK--------TTHQEEDSV 1206
            ||.||..|:.......||:...|.|:|:|:::  ::|.|.|:.:.||:        ..|..:|.|
Human   809 EDYPQAIPELEGIEILNSSAVLVKWRPVDLAQ--VKGHLRGYNVTYWREGSQRKHSKRHIHKDHV 871

  Fly  1207 YYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGINPS 1271
            ...:.||.  .::.||:|.:.|.::|.|:|..|.||.|| |...|....|.. |.::|:.  ..|
Human   872 VVPANTTS--VILSGLRPYSSYHLEVQAFNGRGSGPASE-FTFSTPEGVPGH-PEALHLE--CQS 930

  Fly  1272 TVRVVWRYVSPSQDEEPVEGYKVRIWESDQNMITANNTIVPIGQKLESYINNLTPGKSYNMRVLA 1336
            ...::.|:..|......:.||                                         ||:
Human   931 NTSLLLRWQPPLSHNGVLTGY-----------------------------------------VLS 954

  Fly  1337 Y---SNGGDGRMS----------------SPTL--HFQMGKTTRNG---ANTRHG 1367
            |   ..||.|::|                ||.|  .||:..||:.|   |..|.|
Human   955 YHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREG 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	28/110 (25%)
		I-set	362..462	CDD:254352	27/111 (24%)
		Ig	466..559	CDD:299845	26/103 (25%)
		IG_like	584..657	CDD:214653	21/73 (29%)
		IGc2	586..645	CDD:197706	19/59 (32%)
		Ig	667..751	CDD:299845	16/84 (19%)
		IG_like	676..751	CDD:214653	16/75 (21%)
		IG_like	765..844	CDD:214653	24/82 (29%)
		Ig	773..844	CDD:299845	23/74 (31%)
		I-set	851..940	CDD:254352	23/88 (26%)
		Ig	866..944	CDD:299845	21/77 (27%)
		FN3	944..1043	CDD:238020	23/108 (21%)
		FN3	1053..1146	CDD:238020	28/92 (30%)
		fn3	1156..1244	CDD:278470	27/95 (28%)
		fn3	1259..1346	CDD:278470	13/89 (15%)
L1CAM	NP_000416.1	IG_like	42..125	CDD:214653	24/91 (26%)
		Ig6_L1-CAM_like	53..130	CDD:143210	22/85 (26%)
		Ig	134..228	CDD:299845	25/99 (25%)
		IG_like	249..329	CDD:214653	21/79 (27%)
		Ig3_L1-CAM_like	260..330	CDD:143208	20/69 (29%)
		IG_like	339..421	CDD:214653	16/84 (19%)
		Ig4_L1-CAM_like	347..422	CDD:143275	16/77 (21%)
		IG_like	434..514	CDD:214653	24/85 (28%)
		Ig	441..514	CDD:299845	23/78 (29%)
		I-set	519..608	CDD:254352	23/89 (26%)
		IGc2	532..594	CDD:197706	19/62 (31%)
		Cell attachment site. /evidence=ECO:0000255	554..556		0/1 (0%)
		FN3	612..709	CDD:238020	23/110 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	698..725		10/26 (38%)
		fn3	718..799	CDD:278470	26/85 (31%)
		fn3	824..907	CDD:278470	26/86 (30%)
		FN3	918..1003	CDD:238020	23/128 (18%)
		fn3	1021..1109	CDD:278470
		Bravo_FIGEY	1144..1233	CDD:290593
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1176..1207
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1226..1257
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I11028
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810